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1455 items
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Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study
Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...... sucrose and mannitol at a total concentration of 10% (S+M 2 + 1 10%, S+M 3 + 2 10%, and S+M 1 + 1 10%). The particle size remained almost the same and the PDI was less than 0.200, indicating uniform particle size. However, at a sucrose to mannitol ratio of 2 to 1 (S+M 2 + 1 10%), the cake collapsed ...
... (lyophilizates T, T+-M 1 + 1 and T—+M 3 + 2). The band width is associated with the distribution of the length and orientation of the bonds formed (Sritham and a) Tr an sm it ta nc e (% ) T T T T T T 4000 3500 3000 2500 2000 1500 1000 Wavenumber (cm”) s S+M 1+1 S+M 3+2 100 90 80 ...
... lengths and a wide range of their orientations (Sritham and Gunasekaran, 2017; Wolkers et al., 2004). In contrast, a downward shift of this band was observed in samples T+M 1 + 1 and T+M 3 + 2 (Fig. 7b). Since it was not as pro- nounced as in the samples with sucrose, this result suggests a lower ...Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study" in European Journal of Pharmaceutical Sciences, Elsevier BV (2023). https://doi.org/10.1016/j.ejps.2023.106557
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Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach
Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...... none Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić Дигитални ...
... one Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach | Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić | Pharmaceutics ...
... DK-I-60-3 by Nanonization: A Knowledge-Based Approach Jelena R. Mitrović 1, Branka Divović-Matović 2, Daniel E. Knutson 3 , Jelena B. Ðoković 1, Aleksandar Kremenović 4 , Vladimir D. Dobričić 5, Danijela V. Randjelović 6, Ivana Pantelić 1 , James M. Cook 3 , Miroslav M. Savić 2 and Snežana D ...Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188
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Application of novel Zn-ferrite modified glassy carbon paste electrode as a sensor for determination of Cd(II) in waste water
Stanković Dalibor M, Skrivanj Sandra, Savić Nenad, Nikolić Aleksandar, Vulić Predrag, Manojlović Dragan (2014)Stanković Dalibor M, Skrivanj Sandra, Savić Nenad, Nikolić Aleksandar, Vulić Predrag, Manojlović Dragan. "Application of novel Zn-ferrite modified glassy carbon paste electrode as a sensor for determination of Cd(II) in waste water" in Electroanalysis 26 no. 7, Hoboken, NJ:John Wiley & Sons (2014): 1536-1543. https://doi.org/10.1002/elan.201400095
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Development of a petrographic classification system for organic particles affected by self-heating in coal waste. (An ICCP Classification System, Self-heating Working Group – Commission III)
M. Misz-Kennan, J. Kus, D. Flores, C. Avila, Z. Büçkün, N. Choudhury, K. Christanis, J.P. Joubert, S. Kalaitzidis, A.I. Karayigit, M. Malecha, M. Marques, P. Martizzi, J.M.K. O'Keefe, W. Pickel, G. Predeanu, S. Pusz, J. Ribeiro, S. Rodrigues, A.K. Singh, I. Suárez-Ruiz, I. Sýkorová, N.J. Wagner, D. Životić (2020)Self-heating of coal waste is a major problem in the leading coal-producing and consuming countries, independent of the recent or past coal exploitation history. The phenomenon of self-heating is dependent on many factors such as the properties of organic matter (maceral composition and rank), moisture and pyrite content, climate effects, and storage conditions (shape of the dump or compaction of the coal waste). Once deposited, coal waste undergoes oxidation, which can lead to self- heating with the overall temperatures ...M. Misz-Kennan, J. Kus, D. Flores, C. Avila, Z. Büçkün, N. Choudhury, K. Christanis, J.P. Joubert, S. Kalaitzidis, A.I. Karayigit, M. Malecha, M. Marques, P. Martizzi, J.M.K. O'Keefe, W. Pickel, G. Predeanu, S. Pusz, J. Ribeiro, S. Rodrigues, A.K. Singh, I. Suárez-Ruiz, I. Sýkorová, N.J. Wagner, D. Životić. "Development of a petrographic classification system for organic particles affected by self-heating in coal waste. (An ICCP Classification System, Self-heating Working Group – Commission III)" in International Journal of Coal Geology, Elsevier BV (2020). https://doi.org/10.1016/j.coal.2020.103411
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Dating intrusion and cooling of Cenozoic granitoids in the Dinarides of Southern Serbia and discussion of the geodynamic setting of Paleocene-Miocene magmatism in the Balkan Peninsula.
Schefer S., Cvetković Vladica, Fügenschuh Bernhard, Kounov A., Ovtcharova M., Schaltegger U., Schmid S. (2010)Schefer S., Cvetković Vladica, Fügenschuh Bernhard, Kounov A., Ovtcharova M., Schaltegger U., Schmid S.. "Dating intrusion and cooling of Cenozoic granitoids in the Dinarides of Southern Serbia and discussion of the geodynamic setting of Paleocene-Miocene magmatism in the Balkan Peninsula." in Geophysical Research Abstracts 12, Vienna, Austria:EGU (2010): 2530-2530
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Reprint of Petrological and organic geochemical properties of lignite from the Kolubara and Kostolac basins, Serbia: implication on grindability index
Životić Dragana, Bechtel A., Sachsenhofer R., Gratzer R., Radić D., Obradović M., Stojanović Ksenija (2015)Životić Dragana, Bechtel A., Sachsenhofer R., Gratzer R., Radić D., Obradović M., Stojanović Ksenija. "Reprint of Petrological and organic geochemical properties of lignite from the Kolubara and Kostolac basins, Serbia: implication on grindability index" in International Journal of Coal Geology 157, Amsterdam, Netherlands:Elsevier BV (2015): 165-183. https://doi.org/10.1016/j.coal.2014.07.004
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Geochemistry, Sr–Nd–Pb isotopes and geochronology of amphibole- and mica-bearing lamprophyres in northwestern Iran: Implications for mantle wedge heterogeneity in a palaeo-subduction zone
M. Aghazadeh, Д. Прелевић, Z. Badrzadeh, E. Braschi, P. van den Bogaard, S. Conticelli. "Geochemistry, Sr–Nd–Pb isotopes and geochronology of amphibole- and mica-bearing lamprophyres in northwestern Iran: Implications for mantle wedge heterogeneity in a palaeo-subduction zone" in Lithos 216-217 (2015): 352-369. https://doi.org/doi.org/10.1016/j.lithos.2015.
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Towards Better Valorisation of Industrial Minerals andRocks in Serbia—Case Study of Industrial Clays
... Uyanık, N.Ö.; Eren, M.; Elliott, W.C. Mineralogy, geochemistry, and genesis of bentonites in Upper Cretaceous pyroclastics of the Bereketli member of the Reşadiye Formation, Reşadiye (Tokat), Turkey. Appl. Clay Sci. 2021, 204, 106024. 75. Ilić, M.; Pavlović, V.; Vukas, R.; Beljić, Č. A comparative analysis ...
... on solid mineral resources of the Republic of Serbia to international standards. Tehnika 2009, 60, 6–14. (In Serbian with English abstract) 66. Ilić, M.; Vukas, R. On the Harmonisation of Serbian Classification and Accompanying Regulations of Resources/Reserves of Solid Minerals with the PERC Standards; ...
... exploration of kaolin deposits (Table 5), the dis- tances for groups 1 and 2 for categories A, B and C1 are very strange, and it is not clear based on which they are defined, and they amount to 50–90–200 and 40–70–150 m, respectively. It would be geologically logical for the corresponding distances to be ...Vladimir Simić, Dragana Životić, Zoran Miladinović. "Towards Better Valorisation of Industrial Minerals andRocks in Serbia—Case Study of Industrial Clays" in Resources, MDPI AG (2021). https://doi.org/10.3390/resources10060063
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Towards a Mining Equipment Ontology
... while the right hand size depicts parameters assigned to a specific type of equipment, or its group component. For each parameter assigned to the type of equipment, a data type is defined (numerical or textual), the parameter measuring unit (m, kW, m/min,...), and the parameter type. Thus the right hand ...
... About Function, Washington, D.C. pp. 137 - 140, 1993. [11] Stanković, R., Obradović, I., Kitanović, O., Prodanović, J., Ilić, V.: An aproach to implementation of blended learning in a university setting. In Proceedings of the Second International Conference on e- Learning, eLearning 2011, Belgrade, Serbia ...
... TOWARDS A MINING EQUIPMENT ONTOLOGY Ranka M. Stanković, Ivan Obradović, Olivera Kitanović, Ljiljana Kolonja University of Belgrade, Faculty of Mining and Geology, {ranka|ivano|olja|lily}@rgf.bg.ac.rs Summary: Comprehensive, consistent and standardized definition of terms in a specific area ...Ranka Stanković, Ivan Obradović, Olivera Kitanović, Ljiljana Kolonja. "Towards a Mining Equipment Ontology" in Proceedings of the 12th International Conference Research and Development in Mechanical Industry, RaDMI 2012, September 2012, Vrnjačka Banja, Serbia no. 1, Vrnjačka Banja, Serbia : SaTCIP (Scientific and Technical Center for Intellectual Property) Ltd. (2012)
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Building Terminological Resources in an e-Learning Environment
... 211-220, 2009. [2] Bouzeghoub, A. Elbyed, A., Ontology Mapping for Web-Based Educational Systems Interoperability, IBIS – International Journal of Interoperability in Business Information Systems, No.1, pp.73-84, 2006. [3] Daconta, M. O. et al., 2003. The Semantic Web: A Guide to the Future of XML ...
... Valetta, Malta, May 2010, pp.2283-2287, 2010. [11] Stanković, R., Obradović, I., Kitanović, O., Prodanović, J., Ilić, V., An aproach to implementation of blended learning in a university setting, Proceedings of the Second International Conference on e-Learning, eLearning 2011, September 2011 ...
... and Equipment Selection, Torino, Italy, Vol. 1, pp. 436-441, 2006. [6] Krstev, C., Stankovic, R., Obradovic, I., Vitas, D., Utvic, M., Automatic Construction of a Morphological Dictionary of Multi-Word Units, in IceTAL. Reykavik, Iceland: Springer, pp. 226–237, 2010. [7] Krstev, C., Stankovic ...Ranka Stanković, Ivan Obradović, Olivera Kitanović, Ljiljana Kolonja. "Building Terminological Resources in an e-Learning Environment" in Proceedings of the Third International Conference on e-Learning, eLearning-2012, September 2012, Belgrade, Serbia, Belgrade : Belgrade Metropolitan University (2012)
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An aproach to Implementation of blended learning in a university setting
... Conference on e-Learning (eLearning-2011) AN APPROACH TO IMPLEMENTATION OF BLENDED LEARNING IN A UNIVERSITY SETTING IVAN OBRADOVIĆ, RANKA STANKOVIĆ, OLIVERA KITANOVIĆ, JELENA PRODANOVIĆ, VESELIN ILIĆ University of Belgrade, Faculty of Mining and Geology, {ivano;ranka;olja;jelena.prodanovic;veselin ...
... informal learning in a specific domain. In order to achieve these goals a Semantic Web based infrastructure has been designed, implemented and tested and an educational ontology has been developed. Another example of integration of semantic resources in education is the M-OBLIGE model for building ...
... contains a short definition of the term in both languages, but without any relations between equivalents. An example of a dictionary entry, in English, and then in Serbian, is: geodatabase (GDB), A collection of geographic datasets of various types held in a common file system folder, a Microsoft ...Ivan Obradović, Ranka Stanković, Olivera Kitanović, Jelena Prodanović . "An aproach to Implementation of blended learning in a university setting" in Proceedings of the Second International Conference on e-Learning, eLearning 2011, September 2011, Belgrade, Serbia, Belgrade : Belgrade Metropolitan University (2011)
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Ultrapotassic volcanism from the waning stage of the Neotethyan subduction: a key study from the Izmir-Ankara-Erzincan suture belt, central northern Turkey
Gülmez, F., Genç, S.G., Prelević, D., Tüysüz, O., Karacik, Z., Roden, M. F., Billor, Z.. "Ultrapotassic volcanism from the waning stage of the Neotethyan subduction: a key study from the Izmir-Ankara-Erzincan suture belt, central northern Turkey" in Journal of Petrology 57(3), :Oxford University Press (2016): 561-593. https://doi.org/10.1093/petrology/egw021
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Parametri zbijanja komunalnog otpada određeni različitim laboratorijskim metodama
Jovana M Janković Pantić, Dragoslav R Rakić, Irena G Basarić Ikodinović, Tina D Đurić, Snežana Bogdanović (2021)Zbijanje komunalnog otpada predstavlja jednu od osnovnih faza korišćenja komunalne deponije. Zbog toga je kao i kod drugih nasutih građevina, veoma korisno odrediti parametre zbijanja: maksimalnu suvu zapreminsku težinu (dmax) i optimalnu vlažnost (wopt). Dobijeni rezultati mogu da posluže prilikom projektovanja kapaciteta deponije kao i prilikom definisanja obradivosti otpada. U dosadašnjoj praksi najčešći način određivanja parametra zbijanja je standardna metoda (Proktorov opit) koja se koristi u mehanici tla, uz eventualnu redukciju energije zbijanja. Međutim, različiti tretmani komunalnog otpada na ...... uzorak B, Е=2500 kJ/mž 70 изогак C, E=550 kJ/m" Suv a za pr em in sk a tež ina Y ama x (k N/ m* ) 60 _— = 7—*\\ -; 55 uzorak B, E=550 kJ/m? ~ [ EN RTGR RRAAA EAA о 10 20 30 40 50 60 Optimalna vlažnost М/, (%) Slika 1. Prikaz rezultata Proktorovog орца га nesagoriv Котипа тт ограа ...
... maksimalne suve zapreminskc težinc је Yamax = 3.37 kN/m* - 3.80 kN/m? а interval vlažnosti Wwopt = 138% - 162%. Za četiri puta povećanu energiju zbijanja, maksimalna suva zapreminska težina se kreće u intervalu удпах ~ 4.84 kN/m? - 4.96 kN/m?, a optimalna vlažnost мд = 73% – 111%. Као i u slučaju ...
... 25% рг maksimalnoj suvoj zapreminskoj težini od yamax = 14.5 kN/m?*. Kod čestica sa maksimalnom veličinom frakcija od 19 mm, optimalna vlažnost iznosi Wopr=40%, a postignuta је рп maksimalnoj suvoj zapreminskoj težini od 12 kN/m'. Opšti zaključak па osnovu analiziranih podataka је da maksimalna ...Jovana M Janković Pantić, Dragoslav R Rakić, Irena G Basarić Ikodinović, Tina D Đurić, Snežana Bogdanović . "Parametri zbijanja komunalnog otpada određeni različitim laboratorijskim metodama" in Građevinski kalendar, Savez građevinskih inženjera Srbije (2021)
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Centar za hidrogeologiju karsta - 15 godina nauke i struke
... International Publishing, 692 pp., Cham, Heidelberg, NY, Dordrecht, London . Ristic Vakanjac, V., Stevanovic, Z., Maran Stevanović, A., Vakanjac, B., Čokorilo Ilić, M. (2014): An example of karst catchment delineation for prioritizing the protection of an intact natural area, Monograph: Hydrogeological ...
... 1007/s12665-015- 4090-7 Ristić Vakanjac, V., Stevanović, Z., Maran Stevanović, A., Vakanjac, B., Čokorilo Ilić, M. (2015): An example of karst catchment delineation for prioritizmg the protection of an intact natural area, Environmental Farth Science (G. Derhaefer; ).W. LaMoreaux; O. Kolditz Fd.), Vol. 74 ...
... of 300 m, 4 vertical cameras (diameter 50-70 mm) with high resolution for recording to depths of 300 and 500 m and a camera with a rotating lens for recording to a depth of 300 m. Kamera za snimanje istražnih bušotina prečnika od 50 mm do 70 mm, i dubine do 500 m Camera Jfor recording e ...urednici Saša Milanović, Ljiljana Vasić, Zoran Stevanović, Branislav Petrović. Centar za hidrogeologiju karsta - 15 godina nauke i struke, Beograd : Univerzitet u Beogradu, Rudarsko-geološki fakultet, Centar za hidrogeologiju karsta, 2023
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Mineralogy and thermal properties of clay from Slatina (Ub, Serbia)
Milošević M., Logar M., Kaluđerović L., Jelić I.. "Mineralogy and thermal properties of clay from Slatina (Ub, Serbia)" in Geophysical Research Abstracts Geophysical Research Abstracts 19, Vienna, Austria:Copernicus Publications (2017): 2044
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Characterization of clays from Slatina (Ub, Serbia) for potential uses in the ceramic industry
Milošević M., Logar M., Kaluđerović L., Jelić I.. "Characterization of clays from Slatina (Ub, Serbia) for potential uses in the ceramic industry" in Energy Procedia Energy Procedia 125, :Elsevier (2017): 650-655. https://doi.org/10.1016/j.egypro.2017.08.270
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Geneza i uslovi cirkulacije voda kompleksnih karstnih sistema Kučajsko-beljaničkog masiva
Ljiljana Vasić M. (2017)Ljiljana Vasić M.. Geneza i uslovi cirkulacije voda kompleksnih karstnih sistema Kučajsko-beljaničkog masiva, Beograd:Rudarsko Geološki Fakultet, 2017
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Geotehničko modeliranje tla na osnovu parametara određenih seizmičkimdilatometrom
Dušan Berisavljević M. (2017)Dušan Berisavljević M.. Geotehničko modeliranje tla na osnovu parametara određenih seizmičkimdilatometrom, Beograd:Rudarsko Geološki Fakultet, 2017
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Sorpcija herbicida na neorganski i organski modifikovanom prirodnom montmorionitu iz Bogovine
Lazar M. KALUĐEROVIĆ (2018)Lazar M. KALUĐEROVIĆ. Sorpcija herbicida na neorganski i organski modifikovanom prirodnom montmorionitu iz Bogovine, Beograd:Rudarsko Geološki Fakultet, 2018
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Hidrohemijska zonalnost vodonosnih naslaga Srema
Marko M. Stanić (2004)Marko M. Stanić. Hidrohemijska zonalnost vodonosnih naslaga Srema, Beograd:Rudarsko-geološki fakultet, 2004