Претрага
531 items
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Polyhedral characteristics of the cosalite-type crystal structures
Sabina Kovač, Predrag Dabić, Aleksandar Kremenović, Aleksandar Pačevski, Ljiljana Karanović, Marko V. Rodić, Martina Tribus (2019)Sabina Kovač, Predrag Dabić, Aleksandar Kremenović, Aleksandar Pačevski, Ljiljana Karanović, Marko V. Rodić, Martina Tribus. "Polyhedral characteristics of the cosalite-type crystal structures" in The Canadian Mineralogist, Mineralogical Association of Canada (2019). https://doi.org/10.3749/canmin.1900017
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Comprehensive Profiling of Microbiologically Induced CaCO3 Precipitation by Ureolytic Bacillus Isolates from Alkaline Soils
Olja Šovljanski, Lato Pezo, Jovana Stanojev, Branimir Bajac, Sabina Kovač, Elvira Tóth, Ivan Ristić, Ana Tomić, Aleksandra Ranitović, Dragoljub Cvetković, Siniša Markov (2021)MICP process, kinetic study, calcite, vaterite, MALDI-TOF identification, Bacillus licheniformis, Sporosarcina pasteurii... A.M.; Gorrasi, S.; Zolla, L.; Fenice, M. Evaluation of MALDI-TOF mass spectrometry and MALDI BioTyper in comparison to 16S rDNA sequencing for the identification of bacteria isolated from Arctic seawater. PLoS ONE 2007, 12, e0181860. [CrossRef] [PubMed] 38. Guo, L.; Ye, L.; Zhao, Q.; Ma, Y.; Yang, ...
... Australia, 2008. 18. Šovljanski, O.; Tomić, A.; Lato, L.; Markov, M. Temperature and pH growth profile prediction of newly isolated bacterial strains from alkaline soils. J. Sci. Food Agric. 2019, 100, 1155–1163. [CrossRef] 19. Brlek, T.; Pezo, L.; Voća, N.; Krička, T.; Vukmirović, Ð.; Čolović, ...
... Ivan Ristić 1 , Ana Tomić 1, Aleksandra Ranitović 1, Dragoljub Cvetković 1 and Siniša Markov 1 ���������� ������� Citation: Šovljanski, O.; Pezo, L.; Stanojev, J.; Bajac, B.; Kovač, S.; Tóth, E.; Ristić, I.; Tomić, A.; Ranitović, A.; Cvetković, D.; et al. Comprehensive Profiling of Micr ...Olja Šovljanski, Lato Pezo, Jovana Stanojev, Branimir Bajac, Sabina Kovač, Elvira Tóth, Ivan Ristić, Ana Tomić, Aleksandra Ranitović, Dragoljub Cvetković, Siniša Markov. "Comprehensive Profiling of Microbiologically Induced CaCO3 Precipitation by Ureolytic Bacillus Isolates from Alkaline Soils" in Microorganisms, MDPI AG (2021). https://doi.org/10.3390/microorganisms9081691
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Smanjenje sleganja plitkih temelja primenom mikrošipova
Slobodan Ćorić, Dragoslav Rakić (2021)Mikrošipovi su šipovi malog prečnika koji se grade tako što se u tlu specijalni postupkom formira bušotina koja se zatim armira i injektira. Njihov prečnik je najčešće 150 – 300 mm, a dužina može da bude i više desetina metara. Mikrošipovi mogu da se grade u svim vrstama tla i mogu da budu vertikalni i kosi. Oni se, stoga, koriste kao zamena za konvencionalne šipove i ankere. Primena mikrošipova u fundiranju predstavlja jedan savremeni način izgradnje i sanacije temelja/objekata. ...Slobodan Ćorić, Dragoslav Rakić. "Smanjenje sleganja plitkih temelja primenom mikrošipova" in Zbornik radova međunarodno naučno-stručnog savetovanja Zemljotresno inženjerstvo i geotehnički aspekti građevinarstva, Vrnjačka banja, 3-5. novembar 2021., Beograd : Savez građevinskih inženjera Srbije (2021)
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Stratigraphic implications of the Mio-Pliocene geodynamics in the area of Mt. Avala: new evidence from Torlak Hill and Beli Potok (Belgrade, Serbia)
Mt. Avala is located on the southern margin of the Pannonian basin (SPB), a border zone between the uplifted morphostructures of the Dinarides and Carpathian-Balkanides. Similar to the Pannonian basin, tectonostratigraphic evolution of the Mt. Avala area during the last 23 Ma has is characterized by syn- and post-rifting processes as well as tectonic inversion. Here, we present the results of field investigations of the Miocene‒Pliocene dynamics that led to different spatial positions of the same stratigraphic units (e.g. ...... siboviki KRSTIĆ, Loxoconcha granifera (REUSS), L. mülleri (MEHES), L. porosa (MEHES), L. cf. rhombovalis POKORNY, Candona (Thaminocypris) improbus KRSTIĆ, Candona (Typhlocypris) lunata (MEHES), C. (T.) trigonella HEJJAS, Leptocythere(Amnicythere) miscere KRSTIĆ, L. (A) cf. servica KRSTIĆ, Loxocorniculina ...
... A., MATENCO, L., MAGYAR, I., HORVÁTH, F. & CLOETINGH, S. (2016): The link between tectonics and sedimentation in back-arc basins: new genetic con- straints from the analysis of the Pannonian Basin.‒ Tectonics, 35, 1526–1559. doi: 10.1002/2015TC004109 BALÁZS, A., BUROV, E., MATENCO, L., VOGT, K., FRANCOIS ...
... Belgrade, 87 p. MATENCO, L. & RADIVOJEVIĆ, D. (2012): On the formation and evolution of the Pannonian Basin: Constraints derived from the structure of the junction area between the Carpathians and Dinarides.‒ Tectonics, 31, TC6007, 18–49. doi: 10.1029/2012TC003206 MATENCO, L., MUNTEANU, I., TER BORGH ...Ljupko Rundić, Meri Ganić, Slobodan Knežević, Dejan Radivojević, Miloš Radonjić. "Stratigraphic implications of the Mio-Pliocene geodynamics in the area of Mt. Avala: new evidence from Torlak Hill and Beli Potok (Belgrade, Serbia)" in Geologia Croatica (2019). https://doi.org/10.4154/gc.2019.11
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Стратешко планирање функционалности подземних просторија моделом прогнозе деформација
Лука Црногорац (2023)Релативно велике деформације подградне конструкције у подземним рудницима угља у Републици Србији представљају један од главних проблема за постизање планиране производње угља. Деформације подграде су директна последица статичких и динамичких оптерећења стенске масе и у многоме зависе и од времена трајања изложености подграде утицају подземног притиска. Код ниско механизованог радног процеса долази до повећаног излагања подземних просторија утицају подземног притиска услед дугог производног циклуса који је често пропраћен застојима у раду. Веома често подземне просторије се санирају и по ...Лука Црногорац. Стратешко планирање функционалности подземних просторија моделом прогнозе деформација, Београд : [Л. Црногорац], 2023
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Природни потенцијал минералних вода Србије - Natural potential of mineral waters in Serbia
Оливера Крунић (2021)Оливера Крунић. "Природни потенцијал минералних вода Србије - Natural potential of mineral waters in Serbia" in Рационално коришћење земљишта и вода у Србији - Sustainable Use of Land and Water in Serbia- Serbian Academy of Sciences and Arts; Scientific Conferences Volume CXCVII; Department of Chemical and Biological Sciences, Book 19, Српска академија наука и уметности (2021)
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Mineral Resources of Serbia: Environmental, Societal and Economic Challenges
... production of around 36 billion litres: US (5,500 million L) » Brazil (3,800 million L) » Germany (3,000 million L) = Indonesia (3,000 million L) = Argentina (3,000 million L) » France (1,500 million L) > Thailand (1,400 million L) > Spain (1100 million L) (*STATISTA. Leading Biodiesel Producers Worldwide ...
... PFOS concentration was quite constant (~ 10 ng/L). However, high concentration of PFNA (108 ng/L) was detected in the Tisa River. Other per- and polyfluoroalky1 substances detected in the Tisa River were: PFUnA (10 ng/L), PFOA (3 ng/L), and PFOS (3 ng/L). These results indicated presence of effluents ...
... 19' 20 PAN 22' ii || ii ii \š\L Legend: N \“C· S.— || IćA • 46' — — 77 Subotica Ž M – |::::zk) \\ 774 ž Pannonian z= 5\3 basin (OS _ L (J„„;//;„N«·»_·Sau > š.z'n':j FW&L \ a 4* |MN ___ ) m ~— fš \7 Belgrade { __ Q/ —~ k F w N | 1 rOeeJ M2 ~L bice| KOR e OM až A ' . ...Vladimir Simić, Rade Jelenković, Dragana Životić. "Mineral Resources of Serbia: Environmental, Societal and Economic Challenges" in Serbia: Current Issues and Challenges in the Areas of Natural Resources, Agriculture and Environment,, Nova Science Publishers, Inc. (2019)
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Linear-motor plunger pump increases lifting efficiency
Bojan Martinović, Dušan Đekić, Dušan Danilović, Pavel Isaev. "Linear-motor plunger pump increases lifting efficiency" in Oil & Gas Journal (2022)
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The external aggregation Newton's method for solving nonlinear equations and applications
Marija Paunović, Dejan Ćebić, Nebojša Ralević. "The external aggregation Newton's method for solving nonlinear equations and applications" in The University Thought - Publication in Natural Sciences, Centre for Evaluation in Education and Science (CEON/CEES) (2020). https://doi.org/10.5937/univtho10-24982
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Indeksi kontrole održavanja i korišćenja rotornog bagera
Razvoj površinske eksploatacije se u velikom stepenu zasniva na svestranoj mehanizaciji rudarskih radova. Kako bi se zadovoljili potrebni kapaciteti, neophodna je primena savremene mehanizacije, velikih kapaciteta i pouzdanosti u radu. Naime, sa stepenom povećanja mehanizovanosti radova smanjuje se broj zaposlenih radnika, povećava produktivnost rada, smanjuju troškovi po jedinici proizvoda, a samim tim i povećava ekonomičnost površinske eksploatacije. Predmet istraživanja su rotorni bageri SRs 1200 koji predstavljaju samohodne mašine kontinuiranog dejstva namenjene za otkopavanje jalovine i korisne supstance na površinskim ...Jovana Mitrović, Predrag Jovančić, Dragan Ignjatović, Stevan Đenadić, Filip Miletić. "Indeksi kontrole održavanja i korišćenja rotornog bagera" in XI Međunarodna konferencija "Ugalj i kritični minerali 2023", CCM 2023, Zlatibor, 11-14. oktobar 2023., Beograd : Jugoslovenski komitet za površinsku eksploataciju (2023)
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Mineragenija i potencijalnost karbonatnih sirovina rudnog reona Bjelopavlića (Crna Gora)
Darko M. Božović (2016-09-28)Karbonatne sirovine, obzirom na geološku građu Crne Gore predstavljaju jednu od najznačajnijih nemetaličnih mineralnih sirovina. U Crnoj Gori postoje brojna leţišta karbonatnih sirovina (arhitektonsko - građevinskog i tehničko - građevinskog kamena) koja su istraţena ili su u eksploataciji, među kojima rudni reon Bjelopavlića zauzima najznačajnije mjesto.Dosadašnja istraţivanja karbonatnih sirovina na ovom području imala su, međutim, prevashodno uzak istraţivački cilj, utvrđivanje rezervi arhitektonsko - građevinskog i tehničko - građevinskog kamena određenog leţišta, ili preliminarna ispitivanja kvaliteta krečnjaka u njima, sa ...karbonatne mineralne sirovine, arhitektonsko - građevinski kamen, tehničko - građevinski kamen, karbonatna punila, rudni reon Bjelopavlića, potencijalnost.... d n ja Sađavac L N L VL M M N M M N N 24 Pješivački do M VL L VL M M N M M N N 27 Mali Garač M VL M L M M N M M N N 29 Jovanovići M N L VL M M N M M N N 25 Lalevići L N L VL M M N M M N N 24 Velje brdo N N L VL N N N M M N N 13 M a la Tološi N N L VL L L N L N N N 14 * Nema standarda ...
... st Visočica M M M L M M M M M VL N 37 V eo m a v el ik a Maljat M M M L M M M M M VL VL 39 Vinići M M M L M M M M M VL N 37 Radujev krš M M M L M M M M M VL N 37 Slatina M L M L M M L M M N N 33 V el ik a Klikovače M L M L M M N M M N N 30 Suk L N L VL M M N M M N N 24 ...
... v a S i T i A l F e M n M g C a N a K S P F C l B a S r C u Z n C r N i V B i O M in era l K L -1 / 1 1 ,1 6 4 2 ,2 9 1 8 ,8 0 3 7 ,7 4 F e O / H K L -1 / 2 2 ,4 9 ...Darko M. Božović. "Mineragenija i potencijalnost karbonatnih sirovina rudnog reona Bjelopavlića (Crna Gora)" in Универзитет у Београду, Универзитет у Београду, Рударско-геолошки факултет (2016-09-28)
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English for Geology Students. 2
Lidija Beko (2023)... Comprehension...........t. 163 Part3 REMOTE SENSING .........tte e 164 Mocabulary/:f. a . . K. L. LD.JOO y. OR dd R- tt . wwR o 167 Reading Comprehension...........i.. 168 (Grammar Sporeyi:20. 7 . .ČR L . val ı ı . Mg (evaii6e oOM caL , , 58500 169 JExerGcises-. .NA . JNA NrT. . .7. TON A . .. . ...
... Myths.............a. • Unit4• HYDROLOGICAL CYCLE AND GROUNDWATER HYDROLOGICAL CYCLE......t tt ttt Vocabulary.......... .. d.. aMaR M . da da a lu l, alakejh Reading Comprehension..........i e GRGUNDWA:TERI .. .MRVNVA . |, . R. . ... JN NEKOJ. .Pt . NNNA MV/oveployuliyoog . 20ooo000u0o d0ggD0 ...
... astonishingly adverb in a rather surprising manner; synonyms: amazingly, surprisingly, unexpect- edly; antonyms: expectedly, unsurprisingly channe!l noun a passage along which surface water and groundwater flows detrital load nounload that is formed of rocks, minerals, and sediments divide ...Lidija Beko. English for Geology Students. 2, Belgrade : The Faculty of Mining and Geology, 2023
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Fuzzy optimization in hydrodynamic analysis of groundwater control systems: Case study of the pumping station “Bezdan 1”, Serbia
Dragoljub Bajić, Dušan Polomčić (2014)A groundwater control system was designed to lower the water table and allow the pumping sta-tion “Bezdan 1” to be built. Based on a hydrodynamic analysis that suggested three alternative solutions, mul-ticriteria optimization was applied to select the best alternative. The fuzzy analytic hierarchy process methodwas used, based on triangular fuzzy numbers. An assessment of the various factors that influenced the selec-tion of the best alternative, as well as fuzzy optimization calculations, yielded the “weights” of the alternativesand the ...groundwater lowering, groundwater management scenario, fuzzy analytic hierarchy process,expert knowledge, triangular fuzzy numbers, linguistic variables... predictive hydro- dynamic analysis. The groundwater control sys- DRAGOLJUB BAJIĆ & DUŠAN POLOMČIĆ104 tem is comprised of 12 wells, whose capacity is 40 l/s each. The time needed to lower the water table to below the design elevation and allow for the construction work to proceed is 5 days. • Alternative ...
... Canal 85.16 m.a.s.l.) were used in the predictive hydrodynamic analysis. The groundwater con- trol system is comprised of 12 wells, whose capacity is 40 l/s each. The water table “stabi- lizes” after 7 days of operation of the system. • Alternative 3 (A3): In this case, lowering of the water table was simulated ...
... stages: Baračka Canal 87 m.a.s.l. and Bezdan–Vrbas Canal 86.5 m.a.s.l. The groundwater control system is comprised of 17 wells, whose capacity is 40 l/s each. The time needed to lower the water table to below the design elevation is 8.5 days. Based on the predictive analysis and the three iden- tified ...Dragoljub Bajić, Dušan Polomčić. "Fuzzy optimization in hydrodynamic analysis of groundwater control systems: Case study of the pumping station “Bezdan 1”, Serbia" in Geološki anali Balkanskoga poluostrva, Belgrade : University of Belgrade - Faculty of mining and geology (2014). https://doi.org/10.2298/GABP1475103B
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New data on the age of an Upper Cretaceous clastic-carbonate succession in Brežđe (Western Serbia)
Nevenka Đerić, Nataša Gerzina (2014)... (eds.): Pancardi 2000 Fieldtrip Guidebook. Vijesti, 37/2, 60-68. PAMIĆ,J., GUŠIĆ,L. & JELASKA, V. (1998): Geodynamic evolution of the Central Dinarides. Tectonophysics, 297, 251—268, Amsterdam. PAMIĆ, J., GUŠIĆ, L. & JELASKA, V. (2000): Alpine tectonostratigra- phic units and their geodynamic ...
... and Age of Flyschoid Sediments in the Stru- ganik Section (Western Serbia).- Stratigraphy and Geological Cor- relation, 22/2, 202—218. CSONTOS, L., GERZINA, N., HRVATOVIĆ, H., SCHMID, S. & TO- MLJENOVIĆ, B. (2003): Structure ofthe Dinarides: a working mod- el.– Ann. Univ. Sci. Budapest., Sect ...
... latitude distribution of Ra- diolaria in Campanian (Late Cretaceous) tropical and subtropical oceans.- Micropaleontology, 30/1, 87—115. FILIPOVIĆ, L, PAVLOVIĆ, Z., MARKOVIĆ B.. RODIN, V., MAR- KOVIĆ, O., GAGIĆ, N., ANTIN, B. & MILIĆEVIĆ, M. (1977): Osnovna geološka karta SFRJ – list Gornji Milanovac ...Nevenka Đerić, Nataša Gerzina. "New data on the age of an Upper Cretaceous clastic-carbonate succession in Brežđe (Western Serbia)" in Geologia Croatica (2014)
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Back-arc underplating provided crustal accretion affecting topography and sedimentation in the Adria microplate
Paolo Mancinelli, Vittorio Scisciani, Cristina Pauselli, Gérard M. Stampfli, Fabio Speranza, Ivana Vasiljević (2021)Supported by evidence of deep crustal sources for the observed magnetic anomalies in Central Italy and by outcropping gabbros in the Croatian archipelago, we model the observed gravity and magnetic anomalies in the Central Adriatic Sea and surroundings. We suggest that the major magnetic anomalies in the area are related to a wide underplating and propose that this volume represents the first stage of the back-arc Adria continental breakup in Early Permian times. During the Palaeotethys-Adria collision, underplating has ...Paolo Mancinelli, Vittorio Scisciani, Cristina Pauselli, Gérard M. Stampfli, Fabio Speranza, Ivana Vasiljević. "Back-arc underplating provided crustal accretion affecting topography and sedimentation in the Adria microplate" in Marine and Petroleum Geology, Elsevier Ltd. (2021). https://doi.org/10.1016/j.marpetgeo.2021.105470
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The Rift Sequence Stratigraphy of the Itebej Field (Pannonian Basin, Serbia)
... Dovenyi, I. Dunkl, F. Horvath, L. Lenkey, M. Ștefănescu, P. Szafian, and T. Toth, 1999. Lithospheric structure of the Pannonian basin derived from seismic, gravity and geothermal data, in The Mediterranean Basins: extension within the Alpine Orogen, edited by B. Durand, L. Jolivet, F. Horvath and M. Serrane ...Saša Ivanišević, Jelena Radišić, Ivana Isić, Dejan Radivojević. "The Rift Sequence Stratigraphy of the Itebej Field (Pannonian Basin, Serbia)" in AAPG Vienna, Paratethys petroleum systems between Central Europe and the Caspian Region, Vienna, 26-27 mart, 2019, AAPG (2019)
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Using English Baits to Catch Serbian Multi-Word Terminology
In this paper we present the first results in bilingual terminology extraction. The hypothesis of our approach is that if for a source language domain terminology exists as well as a domain aligned corpus for a source and a target language, then it is possible to extract the terminology for a target language. Our approach relies on several resources and tools: aligned domain texts, domain terminology for a source language, a terminology extractor for a target language, and a ...aligned texts, word alignment, terminology extraction, electronic dictionaries, morphological inflection... ra d̄a bi bl io te čk ig ra d̄a li br ar y m at er ia l 1, 2, 3, 4 bi bl io te ka ib ib li ot eč ke gr ad̄ e bi bl io te ka ib ib li ot eč ki gr ad̄ a bi bl io te čk ig ra d̄a li br ar y m at er ia l 1 gr ad̄ e u bi bl io te ka m a gr ad̄ a u bi bl io te ...
... bl io te ka bi bl io te čk ig ra d̄a li br ar y m at er ia l 1, 3, 5, 6 ye s gr ad̄ u sv e su bi bl io te ke po d gr ad̄ a sa v su bi bl io te ka bi bl io te čk ig ra d̄a li br ar y m at er ia l 1 bi bl io te čk og m at er ij al a bi bl io te čk im at er ...
... at er ij al bi bl io te čk ig ra d̄a li br ar y m at er ia l 1, 3, 5, 6 ye s gr ad̄ e iz dr ug ih bi bl io te ka a gr ad̄ a iz dr ug ib ib li ot ek a bi bl io te čk ig ra d̄a li br ar y m at er ia l 1 bi bl io te čk e st an da rd e bi bl io te čk is ta nd ...Cvetana Krstev, Branislava Šandrih, Ranka Stanković. "Using English Baits to Catch Serbian Multi-Word Terminology" in Proceedings of the 11th International Conference on Language Resources and Evaluation, LREC 2018, Miyazaki, Japan, May 7-12, 2018, European Language Resources Association (ELRA) (2018)
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Why classical sequence stratigraphy doesn't work in Pannonian basin?
Dejan Radivojević (2018)... . Dobb, Geol. Soc. Spec. Publ., 71, 35–66, doi:10.1144/GSL.SP.1993.071.01.03. Sztanó, O., M. Kovač, I. Magyar, M. Šujan, L. Fodor, A. Uhrin, S. Rybar, S., G. Csillag, and L. Tokes, 2016. Late Miocene sedimentary record of the Danube / Kisalföld Basin: interregional correlation of depositio ...
... Galloway, M.R. Gibling, K.A. Giles, J.M. Holbrook, R. Jordan, C.G.S.C. Kendall, B. Macurda, O.J. Martinsen, A.D. Miall, J.E. Neal, D. Nummedal, L. Pomar, H.W. Posamentier, B.R. Pratt, J.F. Sarg, K.W. Shanley, R.J. Steel, A. Strasser, M.E. Tucker, and C. Winker, 2009. Towards the standardizati ...
... Carbonate Sequence Stratigraphy, Recent Development and Applications. American Association of Petroleum Geologists Memoir 57, 545 pp Matenco, L., Radivojević, D., 2012. On the formation and evolution of the Pannonian Basin: Constraints derived from the structure of the junction area between ...Dejan Radivojević. "Why classical sequence stratigraphy doesn't work in Pannonian basin?" in 17th Serbian Geological Congress, Vrnjačka Banja, 17-20 maj 2018, Srpsko geološko društvo (2018)
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Mechanosynthesis and structural characterization of nanocrystalline Ce1–Y O2– (x=0.1–0.35) solid solutions
Martin Fabián, Bratislav Antić, Vladimír Girman, Milica Vučinić-Vasić, Aleksandar Kremenović, Shigeru Suzuki, Horst Hahn, Vladimír Šepelák (2015)A series of nanostructuredfluorite-type Ce1–xYxO2–δ (0rxr0.35) solid solutions, prepared via highenergy milling of the CeO2/Y2O3mixtures, are investigated by XRD, HR-TEM, EDS and Raman spectroscopy. For thefirst time, complementary information on both the long-range and short-range structural features of mechanosynthesized Ce1–xYxO2–δ, obtained by Rietveld analysis of XRD data and Raman spectroscopy, is provided. The lattice parameters of the as-prepared solid solutions decrease with increasing yttrium content. Rietveld refinements of the XRD data reveal increase in microstrains in the host ceria ...Martin Fabián, Bratislav Antić, Vladimír Girman, Milica Vučinić-Vasić, Aleksandar Kremenović, Shigeru Suzuki, Horst Hahn, Vladimír Šepelák. "Mechanosynthesis and structural characterization of nanocrystalline Ce1–Y O2– (x=0.1–0.35) solid solutions" in Journal of Solid State Chemistry, Elsevier BV (2015). https://doi.org/10.1016/j.jssc.2015.06.027
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Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study
Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...... -3.2 L T__= 153.27 *C peak s -48 AH = 162.09 J/g - o i-] o -9 -0.66 = [} —-1.32 > < > -1.98 Š | T_= 154.03 *C % -2.64 |- AH = 77.71 J/g _ šl:) | ii L ii L ii L | L L ı| 0.0 | iii -2.6 -- - -5.2 | J T__= 189.87 *C | peak 8L AH = 126.15 J/g | . L || - l L || L : ıj 0 ...
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... prevent nano- crystal aggregation during spray or freeze-drying. Int. J. Pharm. 471 (1–2), 303-311. https://doi.org/10.1016//j.ijpharm.2014.05.060. L Remmele, R., Krishnan, S., J Callahan, W., 2012. Development of stable lyophilized protein drug products. Curr. Pharm. Biotechnol. 13 (3), 471-496. ...Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study" in European Journal of Pharmaceutical Sciences, Elsevier BV (2023). https://doi.org/10.1016/j.ejps.2023.106557