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1778 items
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Еволуција напонског поља подручја Интерних Динарида у Србији током алпске орогенезе
Ana S. Mladenović (2015-06-19)Циљ ове докторске дисертације био је реконструкција еволуције напонског пољаЗемљине коре у подручју Интерних Динарида у Србији током Алпске орогенезе.Истраживања за потребе решавања овог проблема су изведена у два дела. Првидео обухватао је анализу палеонапона на дефинисаном подручју истраживања,док се други део односио на анализу тренутно активног поља напона у овом делуБалканског полуострва. Истраживано подручје обухвата унутрашњи деоДинарског орогеног појаса, који се простире у централној и западној Србији. Собзиром на циљ истраживања, истраживано подручје је дефинисано тако даобухвата три ...Интерни Динариди, анализа палеонапона, фокални механизмиземљотреса, напонско поље, тектоно-магматски догађаји... Catalogue Preparation, Seismotectonic Modeling and Site Class Definitions. Proceedings of First International Conference, Science And Technology For Safe Development Of Lifeline Systems Natural Risks: Developments, Tools and Techniques in the CEI Area, 4 – 5 November 2003, Sofia, Bulgaria ...
... 3) STRESS FIELD EVOLUTION IN THE AREA OF THE INTERNAL DINARIDES IN SERBIA DURING THE ALPINE OROGENIC CYCLE Abstract The main aim of this PhD thesis was to reconstruct the evolution of the stress field of the Earth's crust in the area of Internal Dinarides in Serbia, during the Alpine orogenic ...
... y most active zones in Serbia: Kopaonik, Kraljevo and Maljen area. Structural-geological field work was done in order to determine the paleostress tensors was done in two of these zones – the Kopaonik and the Maljen ones. Analysis of recently active stress field was done in all three seismogenic ...Ana S. Mladenović. "Еволуција напонског поља подручја Интерних Динарида у Србији током алпске орогенезе" in Универзитет у Београду, Универзитет у Београду, Рударско-геолошки факултет (2015-06-19)
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Еволуција напонског поља подручја Интерних Динарида у Србији током алпске орогенезе
Ana S. Mladenović (2015-06-19)Циљ ове докторске дисертације био је реконструкција еволуције напонског пољаЗемљине коре у подручју Интерних Динарида у Србији током Алпске орогенезе.Истраживања за потребе решавања овог проблема су изведена у два дела. Првидео обухватао је анализу палеонапона на дефинисаном подручју истраживања,док се други део односио на анализу тренутно активног поља напона у овом делуБалканског полуострва. Истраживано подручје обухвата унутрашњи деоДинарског орогеног појаса, који се простире у централној и западној Србији. Собзиром на циљ истраживања, истраживано подручје је дефинисано тако даобухвата три ...Интерни Динариди, анализа палеонапона, фокални механизмиземљотреса, напонско поље, тектоно-магматски догађаји... Catalogue Preparation, Seismotectonic Modeling and Site Class Definitions. Proceedings of First International Conference, Science And Technology For Safe Development Of Lifeline Systems Natural Risks: Developments, Tools and Techniques in the CEI Area, 4 – 5 November 2003, Sofia, Bulgaria ...
... 3) STRESS FIELD EVOLUTION IN THE AREA OF THE INTERNAL DINARIDES IN SERBIA DURING THE ALPINE OROGENIC CYCLE Abstract The main aim of this PhD thesis was to reconstruct the evolution of the stress field of the Earth's crust in the area of Internal Dinarides in Serbia, during the Alpine orogenic ...
... y most active zones in Serbia: Kopaonik, Kraljevo and Maljen area. Structural-geological field work was done in order to determine the paleostress tensors was done in two of these zones – the Kopaonik and the Maljen ones. Analysis of recently active stress field was done in all three seismogenic ...Ana S. Mladenović. "Еволуција напонског поља подручја Интерних Динарида у Србији током алпске орогенезе" in Универзитет у Београду, Универзитет у Београду, Рударско-геолошки факултет (2015-06-19)
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Hydrogeochemical distribution of Ca and Mg in groundwater in Serbia
Petar Papić, Jovana Milosavljević, Marina Ćuk, Rastko Petrović . "Hydrogeochemical distribution of Ca and Mg in groundwater in Serbia" in Groundwater: Occurrence and Significance for Human Health, CRC Press, Balkema - Taylor & Francis Group (2014)
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Arsenic in tape waters of the south Pannonian basin (Serbia) and arsenic risk assessment
Petar Papić, Marina Ćuk, Maja Todorović, Jana Stojković, Bojan Hajdin, Nebojša Atanacković, Dušan Polomčić (2012)... length of some 600 km in an west-east direction, from the eastern edges of the Alps in Austria and Slovenia to the Carpathian Mountains in Romania. In the south, the basin is bordered by the North Dinarides in Croatia, Bosnia and Herzegovina, and Serbia, and in the north by the Tatras in Slovakia. The Danube ...
... tapping aquifers up Arsenic in Tap Water of Serbia’s... 1787 Fig. 3. Histogram of arsenic in groundwater used for drinking water supply in Banat. Fig. 4. Histogram of arsenic concentrations in groundwater used for drinking water supply in Bačka. Fig. 5. Arsenic concentrations in Srem groundwaters. L og ...
... occurrence in drinking water supply systems in ten municipalities in the Vojvodina Region, Serbia. Environ. Res. 111, 315, 2011. 7. VARSANYI I., KOVACS O.L. Arsenic, iron and organic matter in sediments and groundwater in the Pannonian Basin, Hungary. Appl. Geochem. 21, 949, 2006. Arsenic in Tap Water ...Petar Papić, Marina Ćuk, Maja Todorović, Jana Stojković, Bojan Hajdin, Nebojša Atanacković, Dušan Polomčić. "Arsenic in tape waters of the south Pannonian basin (Serbia) and arsenic risk assessment" in Polish Journal of Enivronmental Studies 21 no. 6, Olsztyn, Poland : Polish Journal of Enivronmental Studies (2012): 1783-1790
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Molecular and Isotope Composition of Biomarkers in Immature Oil Shale and its Liquid Pyrolysis Products (Open and Closed System)
Gordana Gajica, Aleksandra Šajnovic, Jan Schwarzbauer, Aleksandar Kostić, Branimir Jovančićević, Ksenija Stojanović (2021)The molecular and isotopic composition of biomarkers in initial bitumen isolated from raw immature oil shale samples from the Lower Miocene Aleksinac Basin (Serbia) and liquid products (LPs) obtained by pyrolysis in open (OS) and closed systems (CS) are studied. The influence of pyrolysis type and variations of kerogen type on biomarkers composition and their isotopic signatures in LPs is determined. The molecular composition of the LPs from the OS pyrolysis is very similar to those in initial bitumen, independently ...... 1979). In LPs from the CS, the Pr/Ph ratio is ~1, that might be caused by the increase of maturity (Peters et al., 2005 and references therein). In initial bitumen, the n-alkan-2-ones are identified in the range of C12–C33. In LPs from the OS, they are present in the range C10–C33, whereas in LPs ...
... homologues, in very low abundance, are detected only. In initial bitumen, the fatty acid methyl esters are identified in the range of C13–C33. The fatty acid methyl esters are present in the range C11–C31 in LPs from the OS, while exclusively odd C17–C23 homologues are detected in LPs from the ...
... distributions in all LPs are characterized by uniform abundances of odd and even homologues, resulting in a reduction of the CPI values (~ 1) in relation to the bitumen (1.37–1.87). In initial bitumen of both raw samples, the pristane/phytane (Pr/Ph) ratio is similar (< 0.4). In LPs from the OS ...Gordana Gajica, Aleksandra Šajnovic, Jan Schwarzbauer, Aleksandar Kostić, Branimir Jovančićević, Ksenija Stojanović. "Molecular and Isotope Composition of Biomarkers in Immature Oil Shale and its Liquid Pyrolysis Products (Open and Closed System)" in 30th International Meeting on Organic Geochemistry (IMOG 2021), European Association of Geoscientists & Engineers (2021). https://doi.org/10.3997/2214-4609.202134040
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A Lexical Approach to Acronyms and their Definitions
In this paper we present a comprehensive approach to acronyms for Natural-Language Processing (NLP) of Serbian texts. The proposed procedure includes extraction of acronyms and their definitions that are usual Multi-Word Units (MWUs), shallow parsing of MWUs that enables MWU lemmatization and production of entries in morphological electronic dictionaries, both for MWU and acronyms, that are provided with grammatical, syntactic, semantic and domain information. This approach enables representation that reflects complex relations between acronyms and their definitions.... beginning of this section and given in many Serbian orthography textbooks. Namely, the acronym in use may be derived from the name in a foreign language (the original name), while the translation of the name is in use, some func- tional words need not be used in acronyms (FHP –âĂŞ Fond za humanitarno ...
... 1). In dealing with acronyms additional problems arise. Namely, as stated in (Spasic et al., 2005), in biomedical texts new acronyms occur in each fifth to tenth abstract, more than 80% of acronyms are ambiguous, and some of them have as much as 15 interpretations. Although the ambiguity in general ...
... obtain names in a dictionary form, normally in the singu- lar, nominative case, sometimes in the plural. (3) KFOR - Medjunarodna mirovna snaga na Kosovu (nominative, singular) KFOR - Medjunarodne mirovne snage na Kosovu (nominative, plural) 4. Checking the list obtained in Step 3 in order to cor- ...Cvetana Krstev, Duško Vitas, Ranka Stanković. "A Lexical Approach to Acronyms and their Definitions" in Proceedings of the 7th Language & Technology Conference, November 27-29, 2015, Poznań, Poland, Springer (2015)
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Business Models for Small-scale Biomass Projects Development
Biomass is recognized as the most promising renewable energy source in Serbia. The share of biomass in Serbian final energy consumption is over 10%, but mostly related to traditional use in stoves and ovens. One of the main obstacles for wider implementation of contemporary biomass facilities is the inexperience of consumers and stakeholders in the implementation of “innovative” business models, especially in the cases of small-scale projects. In this paper, three different business models (public utility company, energy cooperative ...... the project in Kostojevići, but also to be used for a similar project in other Serbian settlements. In all models, the inclusion of local citizens in all phases of biomass supply and utilization chain are presented. 2. Biomass project in Kostojevići The existing district heating system in Kostojevići ...
... business model. In the case of replacement of existing boiler in local school by woodchips boilers, technical staff of PUC “BB Term” would be in charge for operating and maintaining the new boilers. In this model, the local population has the opportunity to participate, as a tenderer, in the process of ...
... energy source in Serbia. The share of biomass in Serbian final energy consumption is over 10%, but mostly related to traditional use in stoves and ovens. One of the main obstacles for wider implementation of contemporary biomass facilities is the inexperience of consumers and stakeholders in the implementation ...Dejan Ivezić, Miodrag Gluščević, Marija Živković. "Business Models for Small-scale Biomass Projects Development" in 19th International Conference on Thermal Science and Engineering of Serbia, Niš : Faculty of Mechanical Engineering (2019)
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Towards the semantic annotation of SR-ELEXIS corpus: Insights into Multiword Expressions and Named Entities
Овај рад представља активности на развоју корпуса ELEXIS-sr, српском додатку вишејезичном анотираном корпусу ELEXIS-а, који се састоји од семантичких анотација и репозиторија значења речи. ELEXIS је паралелни вишејезични анотирани корпус на десет европских језика, који може да се користи као вишејезички репер за евалуацију европских језика са мање и средње развијеним ресурсима. Фокус овог рада је на вишечланим изразима и именованим ентитетима, њиховом препознавању у скупу реченица ELEXIS-sr и поређењу са анотацијама на другим језицима. Разматрају се први кораци ...Cvetana Krstev, Ranka Stanković, Aleksandra Marković, Teodora Mihajlov. "Towards the semantic annotation of SR-ELEXIS corpus: Insights into Multiword Expressions and Named Entities" in Proceedings of the Joint Workshop on Multiword Expressions and Universal Dependencies (MWE-UD) @ LREC-COLING 2024, Turin, May 25, 2024, ELRA and ICCL (2024)
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The state and perspective of the natural gas sector in Serbia
The strategy of long-term energy development of Serbia identifies an increase of share of natural gas in final energy consumption as one of the main aims. Serbia has signed a strategic agreement with the Russian Federation on cooperation in the oil and gas sector, within which the project South Stream pipeline is planned to be realized. In addition, the Republic of Serbia has signed the Treaty that establishes the Energy Community and accepted the obligation to implement the Energy ...Dejan Ivezić, Marija Živković, Dušan Danilović, Aleksandar Madžarević, Miloš Tanasijević. "The state and perspective of the natural gas sector in Serbia" in Energy Sources, Part B: Economics, Planning and Policy, Taylor & Francis Group, LLC (2016). https://doi.org/http://dx.doi.org/10.1080/15567249.2013.858796
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A WordNet Ontology in Improving Searches of Digital Dialect Dictionary
In this paper, we present a method for automatic generation of a digital resource, which connects all indirect synonyms of a dialect term to all indirect synonyms of a corresponding term in the standard language, aiming to improve the search of a digital dialect dictionary. The method uses SWRL rules defined in the Serbian WordNet ontology to identify sets of synonymous words. It also uses e-dictionaries to produce correct lemmas in standard language that users usually employ in searches. ...... found in the dialect dictionary whose definitions contained this verb in the form of the first person singularupropastim. upropastiti | isabim batisem dokrajisem istrovim izabim izakam oznobim profuckam (4) In this step the SWN ontology was used in order to implement inference rules defined in Subsection ...
... table was obtained that contained in each row a verb lemma and its indirect synonyms (in the standard language) as shown in the next example: upropastiti | unerediti, unistiti, uprskati, zabrljati, zajebati, zakrmaciti, zasvinjiti (5) In the final step, tables obtained in steps (3) and (4) were joined ...
... process. In this paper we propose a method for connecting the standard language and the dialect, that would enable search over a digital dialect dictionary by using terms in the standard language. In Section 2 we discuss some previous approaches to searching digital dialect dictionaries. In Section 3 ...Miljana Mladenović, Ranka Stanković, Cvetana Krstev. "A WordNet Ontology in Improving Searches of Digital Dialect Dictionary" in New Trends in Databases and Information Systems: ADBIS 2017 Short Papers and Workshops - SW4CH (Semantic Web for Cultural Heritage) 767, Springer International Publishing (2017). https://doi.org/10.1007/978-3-319-67162-8_37
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Mine ventilation system planning using genetic algorithms
The most common problem in contemporary mining practice related to the planning and analysis of ventilation systems is the optimization of partially regulated air distribution in mine ventilation networks. This paper presents a two step optimization procedure for partly regulated air distribution in mine ventilation networks. The first step is the determination of air distribution in all branches using the well known Hardy-Cross method. In the second step the distribution and parameters of air flow regulators with minimum engaged ...coal, lignite, and peat; ventilation systems; coal mining; underground mining; ventilation; mathematical models; design; air flow; optimization; calculation methodsNikola Lilić, Ranka Stanković, Ivan Obradović. "Mine ventilation system planning using genetic algorithms" in 6. international symposium on mine planning and equipment selection, Ostrava (Czech Republic), 3-6 Sep 1997, A.A. Balkema, Rotterdam (Netherlands) (1997)
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Automatic construction of a morphological dictionary of multi-word units
The development of a comprehensive morphological dictionary of multi-word units for Serbian is a very demanding task, due to the complexity of Serbian morphology. Manual production of such a dictionary proved to be extremely time-consuming. In this paper we present a procedure that automatically produces dictionary lemmas for a given list of multi-word units. To accomplish this task the procedure relies on data in e-dictionaries of Serbian simple words, which are already well developed. We also offer an evaluation ...electronic dictionary, Serbian, morphology, inflection, multiwordn units, noun phrases, query expansion... component in the genitive case, but their inflectional behavior is different: in the first MWU the second component can change in number whereas in the second MWU it does not inflect. For that reason they belong to two different classes (and super- classes), nc nxn4 and nc n4x respectively. In order to ...
... was no additional information in the MWU lemma. For such components this information was subsequently searched in dictionaries of simple words. It was thus possible to establish that in naliv-pero ‘ink pen’ the first component was not in the dictionary of simple words, in bruto plata ‘gross income’ the ...
... 20 24 The rules are applied in the sequence in which they appear in the XML document, which means that if more than one rule can apply for a particular MWU, then more MWU candidate lemmas will be offered in the order of the application of rules. Hence, the order of rules in the strategy is of importance ...Cvetana Krstev, Ranka Stanković, Ivan Obradović, Duško Vitas, Miloš Utvić. "Automatic construction of a morphological dictionary of multi-word units" in Lecture Notes in Computer Science 6233, Advances in Natural Language Processing, Proceedings of the 7thInternational Conference on NLP, IceTAL 2010, Reykjavik, Iceland, August 2010, Springer (2010): 226-237. https://doi.org/10.1007/978-3-642-14770-8_26
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On the compatibility of lexical resources for NooJ
Lexical resources for many languages are provided for the NooJ linguistic development environment. Meta-data descriptions of morphosyntactic and semantic properties of these languages and their resources are a mandatory part of each language module. In this paper we analyze how well the meta-data actually describe resources for a chosen subset of languages and to what extent are they compatible across languages to support multilingual processing. We show that there is place for improvement in both directions.... often exist between semantic codes in metadata (in the *.def file) and those in the text dictionary. For example, in Croatian, the semantic code cons appears in the text dictionary (hraniti,V+FLX=BRANITI+Sem=cons+Prelaz=pov), although it does not exist in the *.def file. Conversely, semantic ...
... on is the proper name Londres, which appears in the French original in the first sentence of the text. In Polish (Londynie) and Croatian (Londonu) translations it is also a proper name, but it does not appear in the English translation at all. In Hungarian (londoni), Bulgarian (лондонски) and ...
... 6 [Type text] Chapter I in which Phileas Fogg and Passepartout accept each other, the one as master, the other as manMr. Phileas Fogg lived, in 1872, at No. 7, Saville Row, Burlington Gardens, the house in which Sheridan died in 1814. He was one of the most noticeable ... Ranka Stanković, Miloš Utvić, Duško Vitas, Cvetana Krstev, Ivan Obradović. "On the compatibility of lexical resources for NooJ" in Automatic Processing of Various Levels of Linguistic Phenomena: Selected Papers from the 2011 International Nooj Conference, Cambridge Scholars Publishing (2012): 96-108
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Quantitative analysis of syllable properties in Croatian, Serbian, Russian, and Ukrainian
Biljana Rujević, Marija Kaplar, Sebastijan Kaplar, Ranka Stanković, Ivan Obradović, Jan Mačutek (2021)Biljana Rujević, Marija Kaplar, Sebastijan Kaplar, Ranka Stanković, Ivan Obradović, Jan Mačutek. "Quantitative analysis of syllable properties in Croatian, Serbian, Russian, and Ukrainian" in Language and Text: Data, models, information and applications, John Benjamins Publishing Company (2021). https://doi.org/10.1075/cilt.356.04ruj
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Strategic Environmental Assessment in the Application of Preventive Protection for Wind Farm Noise—Case Study: Maestrale Ring Wind Farm
Determining the spatial position of wind turbines is the initial and most important phase in the development of a wind farm project. In this sensitive phase, all potential problems that may arise in the later stages of project development should be prevented by means of spatial and urban planning instruments. This makes it possible to achieve maximum use of the potential of wind in a particular space and, thus, fulfil the technical and economic requirements of the project while ...Energija,energetski inženjering i elektroenergetska tehnologija,obnovljivi izvori energije, održivost i životna sredina,električni i elektronski inženjering,kontrola i optimizacija,inženjering... wind turbines in relation to the results obtained. Bearing in mind that the general approach to impact assessment in the SEA process in methodological terms is predominantly expert, qualitative and subjective, but also flex- ible in relation to various precise models and tools used in environmental ...
... shown in Figure 2 for the day (and evening) period and in Figure 3 for the night period. A total of 8 sensitive receptors were selected in the surroundings of the planned Maestrale Ring wind farm and all of the sensitive receptors are situated in the north-western part of the wind farm, in the zone ...
... farms should be viewed in the context of meeting the relevant values set by legisla- tion and their impact in relation to noise considered in that context. The paper shows how the aspect of noise impact from wind farms can be considered in the SEA process. The application of SEA in wind farm planning ...Boško D. Josimović, Aleksandar Cvjetić, Božidar Manić. "Strategic Environmental Assessment in the Application of Preventive Protection for Wind Farm Noise—Case Study: Maestrale Ring Wind Farm" in Energies, MDPI AG (2021). https://doi.org/10.3390/en14196174
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Overwiew of In-Pit Crushing & Conveying Technology in Open Pit Mines
The conditions under which contemporary surface mining operations is carried out obviously becoming increasingly complex. In such complex conditions, the optimization of haulage systems as the technological phase with the largest share in the total operating costs, is very important from the aspect of achieving profitability of the mining project. In a large number of cases, the application of traditional haulage systems with trucks (as the most dominant type of haulage in open pit mines) does not lead to ...Ali Nasirinezhad, Dejan Stevanović, Dragan Ignjatović, Petar Marković. "Overwiew of In-Pit Crushing & Conveying Technology in Open Pit Mines" in 8th International Conference MIining And Environmental Protection, Sokobanja, 22-25 September 2021, University of Belgrade, Faculty of Mining and Geology, Belgrade, Serbia (2021)
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Combining Heterogeneous Lexical Resources
... [close:3, shut:1] in English WN (EWN), ‘make shut’) is in relation CAUSES with synset [zatvoriti se:1x] (in EWN [close:8, shut:2] ‘become closed’). Also, synset [bolestan:1] (in EWN [unhealthy:1]) is in relation NEAR_ANTONYM with synset [zdrav:1] (in EWN [healthy:1]) and in relation BE_IN_STATE ...
... other or be used in its development. In section 2 of this paper we will describe what information from one dictionary can be reused to the benefit of the other. In section 3 we will describe the software tool that performs these tasks, and some obtained results will be given in section 4. 1103 ...
... information accompanying the synset literal in a wordnet is the PoS, and it has to be the same for all literals in one synset. Enriching the synsets with information from SMD makes the usage of a wordnet in an information retrieval task more efficient. In a number of cases this additional information ...Cvetana Krstev, Duško Vitas, Ranka Stanković, Ivan Obradović, Gordana Pavlović-Lažetić. "Combining Heterogeneous Lexical Resources" in Proceedings of the Fourth Interantional Conference on Language Resources and Evaluation, Lisabon, Portugal , May 2004, vol. 4, ELRA - European Language Resources Association (2004)
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Building Terminological Resources in an e-Learning Environment
... Moodle. In this paper we describe how we have tackled this problem1. In the next section we give a brief outline of terminological resources in general and RudOnto in particular. Section 3 offers an overview of state of the art of Moodle implementation and blended learning at FMG. In Section ...
... be a handy tool in exchanging personal messages between students and teachers. Terminology is an important issue in the learning process as students need to be acquainted with the proper use and meaning of terms in the field of their study. In addition to that, especially in the case of the so-called ...
... being developed, with the aim of becoming the reference resource for mining terminology in Serbian in e-format. As a central terminological resource it is also invaluable in the learning process, and it is included in the blended learning approach at the Faculty of Mining and Geology through an export ...Ranka Stanković, Ivan Obradović, Olivera Kitanović, Ljiljana Kolonja. "Building Terminological Resources in an e-Learning Environment" in Proceedings of the Third International Conference on e-Learning, eLearning-2012, September 2012, Belgrade, Serbia, Belgrade : Belgrade Metropolitan University (2012)
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Effects of Energy Production and Consumption on Air Pollution in Serbia
Marija Živković (2019)Energy production and combustion, mostly from unregulated or inefficient fuel combustion, are the single most important anthropogenic sources of air pollutant emissions. Energy sector in Serbia is highly fossil fuel intensive: 87.88% of energy consumed in Serbia is related to fossil fuels, while almost 95% of energy sources are combusted. In 2017. energy related carbon dioxide emission in Serbia is was 47.95 million tones. The main source of carbon dioxide emission was coal, responsible for almost 70% of energy ...... energy consumption in 2017 Coal is mainly used for electricity generation i.e. 88% of total coal energy is utilized in thermal power plants or CHPs. Structure of electricity generation by source is presented in Figure 3. In average about ¾ of electricity in Serbia is generated in TPPs, with average ...
... sources of air pollutant emissions. Energy sector in Serbia is highly fossil fuel intensive: 87.88% of energy consumed in Serbia is related to fossil fuels, while almost 95% of energy sources are combusted. In 2017. energy related carbon dioxide emission in Serbia is was 47.95 million tones. The main source ...
... emissions in Serbia, with attention given to energy consumption in the buildings and the transport sectors, since they are seen as the main sources of air pollution in urban areas due to a great number of uncontrolled or poorly controlled combustion processes. 2.ENERGY CONSUMPTION AND PRODUCTION IN SERBIA ...Marija Živković. "Effects of Energy Production and Consumption on Air Pollution in Serbia" in Mining and Environmental Protection-MEP 2019, University of Belgrade, Faculty of Mining and Geology (2019)
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Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach
Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...... animals per time point): group I received F5 in fasted conditions, group II received F5 in fed conditions, group III received S5 in fasted conditions, and group IV received S5 in fed conditions. The test formulations were administered orally via a gastric probe in a volume of 5 mL/kg (the administered dose ...
... solubility of DK-I-60-3 in medium containing SLS and PVP in concentrations as in F5, F6, and F8 was 5.52 ± 1.22, 3.47 ± 0.25, and 3.05 ± 0.82 µg/mL, respectively, i.e., similar to the solubility in water. As for the polymeric stabilizers, molecular weight is an important factor in overcoming the van der ...
... ANOVA); (b) solubility of DK-I-60-3 in nanocrystal dispersions (F5, F6, and F8) and corresponding suspensions (S5, S6, and S8) in different media at 37 ◦C. Solubility of DK-I-60-3 in nanocrystal dispersions as well as in corresponding suspen- sions was determined in water, 0.1 M hydrochloride acid, and ...Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188