Претрага
4193 items
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Analysis of the exhaust emissions inventory from auxiliary mining machines
Stevan Đenadić, Aleksandar Mirković, Jovana Mitrović, Filip Miletić, Predrag Jovančić, Dragan Ignjatović (2023)Open-pit coal mines are equipped with a large number of mining machines and vehicles with diesel engines. Due to common daily operation of these machines and vehicles large amounts of exhaust gases which contain numerous pollutants are emitted into the atmosphere. The demand to reduce air pollution induced the activities in developed countries to map and calculate all gases emitted by industries to formulate and select adequate preventive activities. In collaboration with machine manufacturers, emission standards for off-road machines ...Stevan Đenadić, Aleksandar Mirković, Jovana Mitrović, Filip Miletić, Predrag Jovančić, Dragan Ignjatović. "Analysis of the exhaust emissions inventory from auxiliary mining machines" in 9th International Conference Mining and Environmental Protection, University of Belgrade, Faculty of Mining and Geology (2023)
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Strain partitioning in a large intracontinental strike-slip system accommodating backarc-convex orocline formation: The Circum-Moesian Fault System of the Carpatho-Balkanides
Nemanja Krstekanić, Liviu Matenco, Uroš Stojadinović, Ernst Willingshofer, Marinko Toljić, Daan Tamminga (2022)oroklini, raspodela deformacija, transkurentna kretanja, Karpato-balkanidi, Cirkum-mezijski rasedni sistem... Matenco, L., Ducea, M.N., Stojadinović, U., Milivojević, J., Đerić, N., 2013. The evolution of a key segment in the Europe–Adria collision: the Fruška Gora of northern Serbia. Glob. Planet. Chang. 103, 39–62. Toljić, M., Matenco, L., Stojadinović, U., Willingshofer, E., Ljubović-Obradović ...
... Fügenschuh, B., Tischler, M., Kissling, E., Spakman, W., 2008. A map-view restoration of the Alpine–Carpathian–Dinaridic system for the Early Miocene. Swiss J. Geosci. 101, 273–294. Ustaszewski, K., Kounov, A., Schmid, S.M., Schaltegger, U., Krenn, E., Frank, W., Fügenschuh, B., 2010. Evolution of the ...
... Willingshofer, Marinko Toljić, Daan Tamminga Дигитални репозиторијум Рударско-геолошког факултета Универзитета у Београду [ДР РГФ] Strain partitioning in a large intracontinental strike-slip system accommodating backarc-convex orocline formation: The Circum-Moesian Fault System of the Carpatho-Balkanides ...Nemanja Krstekanić, Liviu Matenco, Uroš Stojadinović, Ernst Willingshofer, Marinko Toljić, Daan Tamminga. "Strain partitioning in a large intracontinental strike-slip system accommodating backarc-convex orocline formation: The Circum-Moesian Fault System of the Carpatho-Balkanides" in Global and Planetary Change, Elsevier BV (2022). https://doi.org/10.1016/j.gloplacha.2021.103714
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Investigating distant effects of the Moesian promontory: Brittle tectonics along the western boundary of the Getic unit (East Serbia)
In this study, we report evidence for brittle deformation in a part of the Carpatho–Balkan orogen, which is explained in terms of effects of the rigid Moesian promontory of the European plate on fault kinematics in East Serbia. We focus on the westernmost part of the Getic Unit of the East Serbian Carpatho–Balkanides, i.e. the Gornjak–Ravanica Unit, located between two main thrusts that were repeatedly activated from Early Cretaceous to recent times. We combine a new data set on ...Getikum, Mezijska jedinica, Karpato-balkanski orogen, krte deformacije, Gornjačko-ravanička jedinicaAna Mladenović, Milorad D. Antić, Branislav Trivić, Vladica Cvetković. "Investigating distant effects of the Moesian promontory: Brittle tectonics along the western boundary of the Getic unit (East Serbia)" in Swiss Journal of Geosciences, Springer (2019). https://doi.org/10.1007/s00015-018-0324-5
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Analiza osnovnih indikatora upotrebnog kvaliteta mašina pomoćne mehanizacije na površinskim kopovima uglja
Stevan Đenadić, Dragan Ignjatović, Predrag Jovančić, Milena Lekić, Žarko Aleksić, Ivan Janković (2022)Izbor optimalnog tipa mašine i adekvatno upravljanje kroz životni vek je kompleksan zadatak. Osnovna pitanja koje se postavljaju prilikom rešavanja ovog zadatka vezana su za stepen zadovoljenja rada mašine i optimalan trenutak zamene iste. U ovom radu je izvršena analiza rada dozera koji su u radu na površinskom kopu lignita RB Kolubara. Analizom je obuhvaćeno 4 različita proizvođača dozera a to su: Caterpillar, Dressta i Shantui i Liebherr. Analiza je izvršena sa aspekta ukupnih troškova koji se stvaraju i ...Stevan Đenadić, Dragan Ignjatović, Predrag Jovančić, Milena Lekić, Žarko Aleksić, Ivan Janković . "Analiza osnovnih indikatora upotrebnog kvaliteta mašina pomoćne mehanizacije na površinskim kopovima uglja" in XV međunarodna konferencija o površinskoj eksploataciji OMC 2022, 12-15. oktobar, Zlatibor, Jugoslovenski komitet za površinsku eksploataciju (2022)
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Analiza sistema odvodnjavanja površinskog kopa Drmno od podzemnih voda sa severnim savršenim ekranom
Izrada nesavršenog ekrana do drugog sloja uglja na površinskom kopu Drmno, pored zadržavanja postojećih standardnih metoda odvodnjavanja od podzemnih voda linijama bunara, predviđena je poslednje decenije u celokupnoj rudarskoj projektnoj dokumentaciji. Iz objektivnih i subjektivnih razloga njegova realizacija nije ostvarena do danas. U međuvremenu je, uz dodatna geološka istraživanja i promenu dinamike i parametara sistema površinske eksploatacije, došlo do određenih značajnih prostornih promena geoloških i rudarskih uslova u eksploatacionom polju. Ovo je omogućilo preliminarno inoviranje pristupa procesu i konceptu ...Tomislav Šubaranović, Dušan Polomčić, Vladimir Pavlović. "Analiza sistema odvodnjavanja površinskog kopa Drmno od podzemnih voda sa severnim savršenim ekranom" in Zbornik apstrakata sa 9. Međunarodne konferencije Ugalj, Zlatibor, 2019., Jugoslovenski komitet za površinsku eksploataciju (2019)
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Applicability of the risk ranking methodology designed for water reservoirs to tailings storage facilities
The risks associated with operating water reservoirs and tailings storage facilities (TSFs) are different because of their different purposes, methods of construction and operation, and characteristics of the materials impounded and their flow behaviour. Regardless of the differences, these two types of structures are often put in the same category when it comes to risk assessment and the application of relevant methodologies, which may result in unrealistic outcomes. In this paper we investigate whether it is possible to apply ...Dragana Nišić, Dinko Knežević, Aleksandar Cvjetić, Neda Nišić, Vladimir Jovanović. "Applicability of the risk ranking methodology designed for water reservoirs to tailings storage facilities" in Journal of the Southern African Institute of Mining and Metallurgy (2022). https://doi.org/10.17159/2411-9717/1492/2022
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Effect of natural gas composition on methane number: A case of gas reservoirs in Serbia
Natural gas is considered as the most environmentally acceptable fossil fuel, thus it is an alternative to petroleum derivate, dominantly used in internal combustion engines. Physical properties of a fuel as well as behavior during combustion process are affected by its composition. This article presents analysis of effect of natural gas composition on methane number (MN), conducted for natural gas deposits in Serbia. For empirically determination of MN: California air resources board (CARB) method and Linear and Anstalt für ...Marija Živković, Milica Ivić, Dejan Ivezić, Aleksandar Madžarević. "Effect of natural gas composition on methane number: A case of gas reservoirs in Serbia" in Energy Sources, Part A: Recovery, Utilization, and Environmental Effects (2017). https://doi.org/10.1080/15567036.2017.1403518
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Determination of Mechanical Properties of Altered Dacite by Laboratory Methods
This paper presents a methodology for determining the uniaxial and triaxial compressive strength of heterogeneous material composed of dacite (D) and altered dacite (AD). A zone of gradual transition from altered dacite to dacite was observed in the rock mass. The mechanical properties of the rock material in that zone were determined by laboratory tests of composite samples that consisted of rock material discs. However, the functional dependence on the strength parameter alteration of the rock material (UCS, intact ...... were performed on a hydraulic compression testing frame with sufficient pressure capacity and capable of applying a force perpendicular to the specimen base. UCS is calculated according to the following equation: σci UCS = P/A (1) where: P—maximum force at the moment of failure, A—specimen’s cross-section ...
... the composite sample equals the strength was a. of the uniform AD sample was at a percentage of 30% AD. Comparison of the obtained exponential Citation: Rupar, V.; CebaSek, V.; . . . . Milisavljevié, V; Stevanovié, D, equation with practical suggestions shows a good correspondence. The suggested methodology ...
... with a diameter of 54 mm with a ratio of height and diameter of 2:1 were formed. In total, 60 specimens were prepared for laboratory tests, 30 for UCS tests, and 30 specimens for triaxial tests (Figure 5). Minerals 2021, 11, 813 6 of 19 Figure 5. Composite specimens prepared for testing: (a) UCS ...Veljko Rupar, Vladimir Čebašek, Vladimir Milisavljević, Dejan Stevanović, Nikola Živanović. "Determination of Mechanical Properties of Altered Dacite by Laboratory Methods" in Minerals, MDPI AG (2021). https://doi.org/10.3390/min11080813
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Soft computing-based modelling of flotation processes - a review
Jovanović Ivana, Miljanović Igor (2015)Jovanović Ivana, Miljanović Igor. "Soft computing-based modelling of flotation processes - a review" in Minerals Engineering 84 (201, Amsterdam:Elsevier (2015): 34-63. https://doi.org/10.1016/j.mineng.2015.09.020
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Evaluation And Perspectives Of Underground Coal Mines In Serbia
... rs/TehnickiIzvestaji/TEH_Godisnjak2016_web_.pdf, approach 28th August, 2017 [2] RGF, Studija "Sagledavanje stanja i mogućnosti restrukturiranja rudnika za podzemnu eksploataciju uglja u JP Elektroprivreda Srbije", 2002; [3] DMT, RGF, Factis, Studija "Underground coal mining: Sustainability, Mine closures ...
... Serbia The Analytic Hierarchy Process (AHP) is a multi-criteria decision-making approach introduced by Saaty [4]. The AHP method enables users to determine the weights of the parameters in the solution of a multi-criteria problem. In the AHP method, a hierarchical model consisting of objectives ...
... criteria in the AHP method, a certain level of inconsistency may occur. Therefore, the logical consistency of pairwise comparisons must be checked [6]. To measure the consistency of pairwise comparison judgments, the consistency ratio proposed by Saaty [7] is used. A consistency ratio is calculated ...Vladimir Milisavljević, Milena Lekić, Ivica Ristović, Vojin Čokorilo, Aleksandar Cvjetić. "Evaluation And Perspectives Of Underground Coal Mines In Serbia" in 7th Balkan Mining Congress Preceedings - BalkanMine2017, Prijedor, 11-13. oktobar 2017., Banjaluka : University of Banjalika, Faculty of Mining, RS, BiH (2017)
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History of meteorite donations to the Collection of Minerals and Rocks of the University of Belgrade, Faculty of Mining and Geology (Serbia)
... Serbia. One of those who investigated the fall was Prof. Josif Pančić (1814-1888), a natural science professor at the Great School of Belgrade (Beogradska Velika Škola), the precursor of University of Belgrade. A series of subsequent meteorite falls in Serbia (Jelica in 1889, Čačak in 1919, and ...
... Prof. Josif Pančić was a very active and respected scientist across Europe, and with his collaborations and private efforts, he collected 95 well-known meteorites worldwide. Unfortunately, most of this collection went missing during the World War I (Jović, 2002). However, a rather quick development ...
... collection of 30 meteorites was given by a French nobleman, collector and honoured member of the Mineralogical Emperor Society in Saint Petersburg, Marquis de Mauroy (Marquis Adrien Charles de Mauroy, 1848-1927) (Urošević, 1899). The donated collection consists of a small number of meteorite samples from ...Alena Zdravković, Maja Milošević, Kristina Šarić, Ivana Jelić, Ana Černok. "History of meteorite donations to the Collection of Minerals and Rocks of the University of Belgrade, Faculty of Mining and Geology (Serbia)" in 9th International Conference Mineralogy and Museums, Sofia, Bulgaria, Earth and Man National Museum and Bulgarian Mineralogical Society (2021)
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Synthesis, characterization and photocatalytic examination of Co0.9Ho0.1MoO4 nanopowders
Milena Rosić, Maja Milošević, Maria Čebela, Vladimir Dodevski, Vesna Lojpur, Radomir Ljupković, Aleksandra Zarubica (2023)... tic · testing nanostructured material CopoHoo,MoOu indicated the possibility of a promising solution in photocatalytic processes towards green chemistry and sustainable development. 1. M. Rosić, A. Zarubica, A. Šaponjic', B. Babić, J. Zagorac, D. Jordanov, B. Matović, Mater. Res. Bull., 98 ...
... Society for Ceramic Materials preliminary Q-band measurement indicates that this spectrum is a superimposition of the spectra of VO ions located in two different positions in the KGa-l structure). A sharp intense peak near g = 2.002 is assigned to defects that are always present in the clays ...
... estimated by the photocatalytic degradation of crystal violet in aqueous solution. A simple and effective . method for controlling: the composition and morphology of Cop.Hoo,, MoOu is presented in this paper, as well as a potentially new approach in the methodology of inorganic synthesis. During ...Milena Rosić, Maja Milošević, Maria Čebela, Vladimir Dodevski, Vesna Lojpur, Radomir Ljupković, Aleksandra Zarubica. "Synthesis, characterization and photocatalytic examination of Co0.9Ho0.1MoO4 nanopowders" in Programme and the book of abstracts 7th Conference of The Serbian Society for Ceramic Materials 7CSCS-2023, June 14-16, 2023 Belgrade, Serbia , Beograd : Institut za multidisciplinarna istraživanja (2023)
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Approach to operational mine planning: Case study Tamnava West
... R. Stevanović, Univerzitet u Beogradu, Rudarsko-geološki fakultet, Beograd Mirjana Banković, Univerzitet u Beogradu, Rudarsko-geološki fakultet, Beograd Milica Pešić Georgiadis, Univerzitet u Beogradu, Rudarsko-geološki fakultet, Beograd Ranka Stanković, Univerzitet u Beogradu, Rudarsko-geološki ...
... s. Coal quality control between the mine site and the utility plant is a complex problem owing to the variable nature of coal properties (heating value, sulfur, ash), even within the same coal seam. In order to ensure a normal and efficient operation of the power plants fed with coal it is ...
... The case study is conducted on open pit Tamnava West field. Tamnava West is a part of Kolubara coal basin, and it operates under governance of Electric Power Industry of Serbia (EPS). Currently, Tamnava West is a biggest coal open pit in Serbia, with capacity of 13 million tons of coal per ...Dejan Stevanović, Mirjana Banković, Milica Pešić Georgiadis, Ranka Stanković. "Approach to operational mine planning: Case study Tamnava West" in Tehnika, Beograd : Savez inženjera i tehničara Srbije (2014). https://doi.org/10.5937/tehnika1406952S
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First paleomagnetic and magnetic anisotropy results from Montenegrо - the coastal area
... uppermost unit is theHigh Karst zone developed in a carbonate platform environment from the Middle Triassic till theend of the Cretaceous. In this unit flysch sedimentation started after the K/T boundary.From the above units we drilled and oriented in situ a total of 248 samples representing ninelocalities ...
... paleomagnetic directions, but maybe with magnetic anisotropy governed NRMs.The rocks in the Budva zone show a large variation in lithological sense as well as in their magneticproperties. Except a Pietra Verde localitiy, the magnetic susceptibilities are weak, we can notdefine AMS fabrics, yet most of ...
... of the localities yielded fairly good paleomagnetic results, whichsuggest pre-folding age of the acquisition followed by a large CW rotation of unit.From the High Karst, only a single Lower Jurassic pelagic limestone provided paleomagnetic results which exhibit CW rotation. The others had weak magn ...Emö Márton, Vesna Cvetkov, Martin Đaković, Vesna Lesić, Slobodan Radusinović. "First paleomagnetic and magnetic anisotropy results from Montenegrо - the coastal area" in General Assembly 2021, Europen Geosciences Union (2021)
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Energetska bezbednost sektora prirodnog gasa Srbije
U prve dve decenije 21. veka obezbeđivanje sigurnosti snabdevanja prirodnim gasom domaćeg tržišta bio je jedan od prioriteta razvoja energetike Srbije. Istovremeno, aspekt sigurnog snabdevanja bio je neizostavni deo slagalice stvaranja energetske bezbednosti. Izražena uvozna zavisnost je dominantna karakteristika sektora prirodnog gasa, tačnije, Republika Srbija je snažno zavisna od ruskog gasa, sa više od 80% uvezenih količina gasa, a do pre dve godine snabdevala se isključivo kroz jednu interkonekciju. U radu se razmatra aktuelna situacija u sektoru prirodnog ...... je snažno zavisna od ruskog gasa, sa više od 80% uvezenih količina gasa, a do pre dve godine snabdevala se isključivo kroz jednu interkonekciju. U radu se razmatra aktuelna situacija u sektoru prirodnog gasa, razlika u odnosu na ranije periode i potencijalni trend procene sigurnosti snab- devanja ...
... strukturnog razvoja u poređenju sa predviđenim strateškim planovima razvoja, respektivno. U ovom radu je predstavljena i nova metodologija za ut- vrđivanje uticaja spremnosti sistema i broja izvora i pravaca snabdevanja, kao i njihove međusobne interakcije, na sigurnost snabdevanja, a u krajnjoj liniji ...
... Univerzitet u Beogradu. Diplomirao, završio master studije i doktorirao je u okviru naučne oblasti Naftno rudarstvo, mehanizacija i automatizacija u rudarstvu, na Rudarsko- geološkom fakultetu, Univerzitet u Beogradu, gde je i prvi put biran u zvanje 2014. godine. Autor je velikog broja radova u međunarodno ...Aleksandar Madžarević, Predrag Jovančić, Miroslav Crnogorac. "Energetska bezbednost sektora prirodnog gasa Srbije" in 36. Međunarodni kongres o procesnoj industriji – Procesing ’23, Šabac, 1. i 2. juna 2023. , Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS) Društvo za procesnu tehniku (2023)
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The optimization of auxiliary machinery in open-cast lignite mines: a case study of bulldozers
One of the most important prerequisites for the successful operation of the open-cast lignite mine is to carry out all the auxiliary works timely with the necessary quality. The most important and most commonly used auxiliary machines are bulldozers. Engaging time of bulldozers use is in direct relation with the coefficients of the time and capacity utilization of the continuous system for the excavation of coal and tailings, which indicates their importance. More than 100 bulldozers have been hired ...... lignite mines: a case study of bulldozers Dragan Ignjatović, Predrag Jovančić, Stevan Đenadić, Ivan Janković, Ivica Ristović Дигитални репозиторијум Рударско-геолошког факултета Универзитета у Београду [ДР РГФ] The optimization of auxiliary machinery in open-cast lignite mines: a case study of ...
... increasing rate of failures. A о Area ог decreasing Area of constant Area ofincreased 3 failure rate , failure rate | failure rate G > » » д 1 ı — || ı о 1 || о || || — ı || ~ ı 1 c 1 ı ı 1 1 ı ı ı ı ı ı ı а зЖ - Time Figure 5. "Bath tub" curve, a relatioh of time апа failure ...
... иИ 2000 - / es / —о— Аџегаве геа!7еа moto hours — — Ауегаве рјаппеа stoppages 1000 + —-—Average ипрјаппеа stoppages 500 4 + Tr ту — А А Ак.к Д 0 т т 7 т т т — 7 1.year 2. уеаг 3. уеаг 4. уеаг 5. уеаг 6. уеаг5 7. уеаг5 8. уеаг5 9. уеаг5 10. уеаг5 Figure 1. Тће акегаре number ој achieved ...Dragan Ignjatović, Predrag Jovančić, Stevan Đenadić, Ivan Janković, Ivica Ristović. "The optimization of auxiliary machinery in open-cast lignite mines: a case study of bulldozers" in 7th International Symposium Mining and Environmental Protection, University of Belgrade, Faculty of Mining and Geology, Belgrade, Serbia (2019)
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The impact of temporal variability of groundwater levels on groundwater vulnerability maps in karst terrains – a case example of the Perućac spring catchment area
Groundwater vulnerability maps represent an essential tool for protecting karst groundwater resources. Vulnerability assessment is usually based on spatial evaluation of various parameters that affect the vulnerability degree and regulate the protection role of the unsaturated zone. Most of these parameters, like soil and geology conditions, are constant and do not change during the year or over several years. In contrast, some parameters, such as the groundwater level, depend on the variability of recharge conditions. By considering the variability ...Vladimir Živanović, Igor Jemcov, Nebojša Atanacković. "The impact of temporal variability of groundwater levels on groundwater vulnerability maps in karst terrains – a case example of the Perućac spring catchment area" in 5th IAH CEG conference, Slovenian Committee of International Association of Hydrogeologists - SKIAH (2022)
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Распоред минских бушотина код израде хоризонталних и косих подземних просторија
Јеремија Баралић (2024)Овај рад бави се анализом и прорачуном расподеле минских бушотина приликом израде хоризонталних и косих подземних просторија у оквиру рударских операција. Главни циљ рада је да пружи јасне смернице за ефикасно и безбедно извођење бушаћко-минерских радова у различитим геолошким условима, уз посебан акценат на оптимизацију расподеле бушотина и прорачун потребне количине експлозива. У раду је детаљно обрађено неколико кључних аспеката: врсте минских бушотина (заломне, помоћне и периферне), фактори који утичу на њихов распоред, као и методе за прорачун оптималне ...... BA H EKCIIJIO3MBHHX CPEJICTABA KojuH Je ypaljeH 01 MEHTOpCTBOM Paje Tokamuh, peoBHu rpodQecop (uwe, npe3ue u 36atbe) aa JliHrHraJiHH peno3HTOpHJyM 3aBpIHHHX pajioBa PI'D-a. HOTBpZ[a cc I/IBHaje 3a HOTpeče OHČJ'I)CH)& 3a CTyJIČHTCKa H HacTaBHa IIHTaAMba H HC MO)JKC CC KOPpHCTHTH y JIpyre cBpXe ...
... IIDHCyCTBO CHOOOJHHX HOBpHmHa. IIocrojH HCKOJIHKO THHHUHHX IHeMa 34 pacnmope,n MHHCKHX OymoTHHa, a CBaKa OJLU PHX HMAa CBOJC TIpe)iHOCTH H IIpHMeHy y 3aBHCHOCTH OJI yCJIOBa Ha TEpecHy. 3.5.1. 3aznone OymroTuHe u (bopMHpabe cJI000/iHe IOBPpinHHe V nehaHH pyhapckux panoBa, (opMHpame cHOOOJIHC HOBPIHHHC ...
... eKCIIJIO3HBa 348 KOHTypHO MHHHpaMbe (Kr), • P-oOMM KOHTypHHx OymroTHHa (m), • A - nopBprmna nornpeuHor rpeceka MuHHpaHe ripocTopuje (m?), • K — KopeKmMoHH (bakTop, 3aBHCaH OJL BpcTe creHc (oOHuHO M3Me)D)y 1,5 u 2,5). Ha npHMep, 3a KOHTypHy IHIpOCTOpHJy Ca HOBPIHHHOM rtipeceKa oJ 10 MP, OOMMOM ...Јеремија Баралић. Распоред минских бушотина код израде хоризонталних и косих подземних просторија, 2024
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Rock slope stability analysis under Hoek–Brown failure criterion with different flow rules
The stability analysis of homogeneous rock slope following the Hoek–Brown failure criterion under the hypothesis of different flow rules is performed based on limit equilibrium and finite element methods. The applied failure criterion is the generalized Hoek–Brown that can be introduced as a shear/normal function in analysis applying different flow rules. The results are compared with those obtained by the application of equivalent shear strength parameters of the Mohr–Coulomb criterion, considering that this is still the most widely used ...Kružna klizna površ, Huk-Braunov kriterijum loma, Kriterijum popuštanja, Smičuća/normalna funkcija, Nivo napona, Verovatnoća i parametarska analizaSvetlana Melentijević, Zoran Berisavljević, Dušan Berisavljević, Claudio Olalla Marañón . "Rock slope stability analysis under Hoek–Brown failure criterion with different flow rules" in Bulletin of Engineering Geology and the Environment , Springer (2024). https://doi.org/10.1007/s10064-024-03667-0
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Human Hemoglobin and Antipsychotics Clozapine, Ziprasidone and Sertindole: Friends or Foes?
Lena Platanić Arizanović, Nikola Gligorijević, Ilija Cvijetić, Aleksandar Mijatović, Maja Krstić Ristivojević, Simeon Minić, Aleksandra Nikolić Kokić, Čedo Miljević, Milan Nikolić (2023)Packed with hemoglobin, an essential protein for oxygen transport, human erythrocytes are a suitable model system for testing the pleiotropic effects of lipophilic drugs. Our study investi gated the interaction between antipsychotic drugs clozapine, ziprasidone, sertindole, and human hemoglobin under simulated physiological conditions. Analysis of protein fluorescence quenching at different temperatures and data obtained from the van’t Hoff diagram and molecular docking indicate that the interactions are static and that the tetrameric human hemoglobin has one binding site for ...Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, CatalysisLena Platanić Arizanović, Nikola Gligorijević, Ilija Cvijetić, Aleksandar Mijatović, Maja Krstić Ristivojević, Simeon Minić, Aleksandra Nikolić Kokić, Čedo Miljević, Milan Nikolić. "Human Hemoglobin and Antipsychotics Clozapine, Ziprasidone and Sertindole: Friends or Foes?" in International Journal of Molecular Sciences, MDPI AG (2023). https://doi.org/10.3390/ijms24108921