The influence of structural modification of Pd(II) pincer-type complexes on the kinetics of substitution reactions

Објеката

Тип

Рад у зборнику

Верзија рада

објављена

Језик

енглески

Креатор

Snežana Jovanović Stević, Snežana Radisavljević, Aleksandar Mijatović, Biljana Petrović, Ana Kesić

Извор

2nd International Conference on Chemo and BioInformatics ICCBIKG 2023, 28-29 September 2023, Institute for Information Technologies, University of Kragujevac, Serbia

Издавач

Kragujevac : Institute for Information Technologies, University of Kragujevac

Датум издавања

2023

Сажетак

This mini-review summarizes the kinetic data obtained for the substitution reactions of some palladium(II) complexes containing bis-pyrazolylpyridine derivatives as pincer-type ligands with biologically significant nitrogen- and sulfur-donor biomolecules as nucleophiles. Three structurally different palladium(II) complexes were selected: [Pd(L1)Cl]+ (Pd1), [Pd(L2)Cl]+ (Pd2) and [Pd(L3)Cl]+ (Pd3) (where L1 = bis(2-(1H-pyrazol-1-yl)ethyl)amine, L2 = 2,6-bis(5-(tert-butyl)-1H-pyrazol-3-yl)pyridine, and L3 = 2,6-bis(5-(tert-butyl)-1-methyl-1H-pyrazol-3-yl)pyridine, while for the entering nucleophiles were used thiourea (Tu), L-methionine (L-met), and guanosine-5’-monophosphate (5’-GMP). Kinetic measurements were carried out for all systems as pseudo-first order reactions (at least 10 times the ligand in excess relative to the complex) under physiological conditions using a stopped-flow UV-Vis spectrophotometer. By comparing the published results for the second-order rate constant, the relationship between the structural properties of the complexes and their reactivity towards selected nucleophiles was established. This overview shows that by tuning the lability of the inert ligands through steric and electronic (σ-donor and π-acceptor) effects, the biological behavior of the complexes can be significantly changed.

isbn

978-86-82172-02-4

Шира категорија рада

М30

Ужа категорија рада

М33

Права

Затворени приступ

Лиценца

Creative Commons – Attribution-No Derivative Works 4.0 International

Формат

.docx

ORCID

https://orcid.org/0000-0002-5553-9244

Скупови објеката

Александар Мијатовић

Radovi istraživača

Snežana Jovanović Stević, Snežana Radisavljević, Aleksandar Mijatović, Biljana Petrović, Ana Kesić. "The influence of structural modification of Pd(II) pincer-type complexes on the kinetics of substitution reactions" in 2nd International Conference on Chemo and BioInformatics ICCBIKG 2023, 28-29 September 2023, Institute for Information Technologies, University of Kragujevac, Serbia, Kragujevac : Institute for Information Technologies, University of Kragujevac (2023)

This item was submitted on 13. октобар 2023. by [anonymous user] using the form “Рад у зборнику радова” on the site “Радови”: http://dr.rgf.bg.ac.rs/s/repo