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Упит dcterms_creator_txt:Janković R

818 items

  • Prostorni položaj ofiolita istočne Vardarske zone: geofizičko-geološki model i njegove geodinamičke implikacije

    Dragana D. Petrović (2015-12-29)
    Centralni deo Balkanskog poluostrva je geotektonski veoma složen. Tetis je zatvorentokom gornjeg mezozoika, a ofioliti na zapadu i ofioliti Vardarske zone predstavljajuostatke nekadašnjih okeanskih prostora. Najistočniji deo Vardarske zone razlikuje se odsvih ostalih ofiolita na Balkanskom poluostrvu i karakteriše se najizraženijim suprasubdukcijskimafinitetom. Istočna vardarska zona locirana je u centralom delu Srbije.Na severu se prostire do Apusena u Rumuniji, a na jugu obuhvata cetralni deoMakedonije i Peonias zonu u severnoj Grčkoj. Istočna vardarska zona se nalazi istočnood geotektonske jedinice Kopaonik ...
    Istočna vardarska zona; ofioliti; 2D i pseudo 3D geofizičko-geološkimodel; geodinamička evolucija
    ... Geological Society of America Special Paper 349, p. 351-364 Cooper, G. R. J., and Cowan, D. R. D., 2005. Differential reduction to the pole, Computers & Geosciences v.31, p.989-999. 104 Cooper, G. R. J., Cowan, D. R. D., 2006. Enhancing potential field data using filters based on the local ...
    ... 10.1007/BF01164221. Coleman, R., G., 1977. Ophiolites-Ancient oceanic litosphere?: Minerals and rocks, Berlin, Springer-Verlag, v. 12, p. 229 Coleman, R. G., 1981. Tectonic setting for ophiolite obduction in Oman, J. Geophys. Res. 86, 2497-2508. Coleman, R. G., 2000. Prospecting for ophiolites ...
    ... pozitivan/negativan polaritet NRM), R-intenzitet NRM, k - magnetska susceptibilnost i σ - gustina prilikom modelovanja: 1 SMM, 2 ofioliti, 3 kredni sed., 4 jurski sed., 5 granitoidi) br oznaka stena koordinate NRM k σ x y D ° I° R (nT) SI 10 -6 SI (t/m 3 ) ...

  • Atmospheric exposure vs burying: influences on damage intensity of built-in kersantite in the monument of the Small Staircase (Belgrade, Serbia)

    Nevenka Novaković, Predrag Dabić, Vesna Matović (2023)
    Proučavan je efekat „zatrpanog kamena“ na intenzitet procesa degradacije prisutnih na kersantitu koji je ugrađen u spomenik Malo stepenište. Istraživanja su vršena na uzorcima stene iz kamenoloma i na oštećenim kamenim blokovima ugrađenim u spomenik. Dok su neki delovi stepeništa bili pod zemljom 90 godina, većina kamenih elemenata je bila izložena različitim uslovima sredine i antropogenim uticajima. Urađeno je detaljno mapiranje trenutnog stanja spomenika kako bi se istražio uticaj “zatrpavanja” i kompleksne geometrije spomenika na tip propadanja i variranje ...
    Raspadanje, Indeks oštećenja, Zatrpavanje, Fizička svojstva, Kersantit

  • Agates of the Lece Volcanic Complex (Serbia): Mineralogical and Geochemical Characteristics

    Zoran Miladinović, Vladimir Simić, Nenad Nikolić, Nataša Jović Orsini, Milena Rosić (2024)
    Agate veins and nodules occur in the Lece Volcanic Complex (Oligocene-Miocene) situated in the south of Serbia and occupying an area of 700 km2. This volcanic complex is composed predominantly of andesites, with sporadic occurrences of andesite-basalts, dacites and latites, and features agate formations that have been very little investigated. This study focuses on five selected agate occurrences within the Lece Volcanic Complex, employing optical microscopy, scanning electron microscopy (SEM), X-ray powder diffraction analysis, inductively coupled plasma mass spectrometry ...
    Lecki vulkanski kompleks, andeyit, kalcedon, kvarc, opal-CT, mikrostruktura, organska materija

  • Compaction of Municipal Solid Waste

    Jovana Janković Pantic, Dragoslav Rakić, Tina Đurić, Irena Basarić Ikodinović, Snežana Bogdanović (2022)
    Regardless of the numerous activities undertaken to reduce municipal solid waste, its annual volumes continue to grow. In Serbia, the most common and the only one form of waste disposal is at municipal landfills with daily compaction and soil covering. Municipal waste compacting is one of the basic components of the disposal process. Well compacted waste takes up less volume and allows much safer storage. In order to better predict the behavior of municipal waste at landfills, it is ...
    compaction, hammer with spikes, landfill, municipal solid waste, proctor compaction test

  • Constitutive Model for Analysis of Long-Term Municipal Solid Waste Landfill Settlement

    Irena Basarić Ikodinović, Dragoslav Rakić, Mirjana Vukićević, Sanja Jocković, Jovana Janković Pantić (2022)
    Large long-term settlement occurs at the municipal solid waste landfills over an extended period of time which may lead to breakage of the geomembrane, damage of the cover systems, other protective systems or facilities constructed on top of a landfill. Also, municipal solid waste is an extremely heterogeneous material and its properties vary over location and time within a landfill. These material characteristics require the formulation of a new constitutive model to predict the long-term settlement of municipal solid ...
    constitutive model, finite element analysis, municipal solid waste, settlement

  • Analiza osnovnih indikatora upotrebnog kvaliteta mašina pomoćne mehanizacije na površinskim kopovima uglja

    Stevan Đenadić, Dragan Ignjatović, Predrag Jovančić, Milena Lekić, Žarko Aleksić, Ivan Janković (2022)
    Izbor optimalnog tipa mašine i adekvatno upravljanje kroz životni vek je kompleksan zadatak. Osnovna pitanja koje se postavljaju prilikom rešavanja ovog zadatka vezana su za stepen zadovoljenja rada mašine i optimalan trenutak zamene iste. U ovom radu je izvršena analiza rada dozera koji su u radu na površinskom kopu lignita RB Kolubara. Analizom je obuhvaćeno 4 različita proizvođača dozera a to su: Caterpillar, Dressta i Shantui i Liebherr. Analiza je izvršena sa aspekta ukupnih troškova koji se stvaraju i ...
    rudarstvo, mehanizacija, upotrebni kvalitet, troškovi, empirijska raspoloživost

  • Age and microfacies of oceanic Upper Triassic radiolarite components from the Middle Jurassic ophiolitic mélange in the Zlatibor Mountains (Inner Dinarides, Serbia) and their provenance

    Hans-Juergen Gawlick, Nevenka Đerić, Sigrid Missoni, Nikita Bragin, Milan Sudar, Divna Jovanović (2017)
    Neo-Tethys, trench-like basins, synorogenic deposition, evolving thrust belt, Triassic palaeogeography
    ... Krystyn L., Lein R., Missoni S. & Schlagintweit F. 2008: Mirdita Zone ophiolites and associated sediments in Albania reveal Neotethys Ocean origin. Tnt. J. Earth Sci. 97, 865–881. Gawlick H.-J., Missoni S., Schlagintweit F., Suzuki H., Frisch W., Krystyn L., Blau J. & Lein R. 2009a: Jurassic ...
    ... N., Missoni S., Lein R. & Jovanović D. 2009b: Upper Triassic and Middle Jurassic radio- larians from the ophiolitic melange of the Dinaridic Ophiolite Belt, SW Serbia. Veues Jahrb. Geol. Palćiontol. 4bh. 253, 2—3, 293—11. Gawlick H.-J., Goričan Š., Missoni S. & Lein R. 2012a: Late Anisian ...
    ... P., Lein R., Frisch W. & Hoxha L. 2016a: Middle and Upper Triassic radiolarite components from the Kcira-Dushi-Komani ophiolitic mćlange and thcir provenance (Mirdita Zone, Albania). Revue de micro- palečontology 59, 359—380. Gawlick H.-J., Missoni S., Suzuki H., Sudar M., Lein R. & Jovanović ...

  • An optimal sixteenth order family of methods for solving nonlinear equations and their basins of attraction

    Dejan Ćebić, Nebojša Ralević, Marina Marčeta (2020)
    нелинеарна једначина, 16.ред конвергенције, оптималне методе, подељене разлике

  • Rezultati ispitivanja parametara čvrstoće i dinamičkih svojstava mermera i mogućnost njihove korelacije

    Jelena Majstorović-Necković, Vladimir Čebašek, Veljko Rupar (2023)
    Ispitivanja stena kao radne sredine, odnosno materijala sa kojim se gradi, na kome se gradi i u kome se gradi, svojom složenošću zahteva njeno svestrano izučavanje po velikom broju parametara. Zadatak Mehanike stena je da što bolje upozna ponašanje stenske mase i njenu otpornost na dejstvo pritiska, zatezanja i smicanja, kao i dinamičkih svojstava. Poznavanje navedenih parametara i njihova korelacija omogućavaju pouzdaniji izbor parametara za projektovanje danas sve zahtevnijih uslova kako podzemne, tako i površinske eksploatacije. U ovom radu ...
    mermer, jednoosna čvrstoća na pritisak, čvrstoća na istezanje, brzina longitudinalnih elastičnih talasa, korelacija

  • Analysis and visualization of geophysical well-logging data from closely spaced boreholes

    Branislav Sretković, Ivana Vasiljević, Dimitry Sidorov - Biryukov (2024)
    Geophysical logging measurements for determining the condition of the rock mass on the dam profile and locating the predisposed directions of water circulation and loss from the reservoir were conducted in four boreholes distributed at a close distance. The survey was carried out in a typical karst terrain, which is an additional challenge for defining the geological model, especially in terms of water retention. That kind of data set provides an excellent opportunity for a new approach to analysis ...
    well-logging in karst, water loss, data correlation, data fusion
    ... values of 101 correlation coefficient R) shows ruptures and karstified zones. Be va to n( m) Detance (m) Figure 1. Integration of 1D log data Kom boreholes into 2D view. Examples: (a) gamma ray and (b) spontaneous-potential logs. Sn-Gamma (b) R a 4 Sp-Gamma (a) Pwat3 Ele vat ion ...
    ... OGRAPHIC AND CHEMICAL CHARACTERISTICS OF ANCIENT SAMPLES FROM THE ARHAEOLOGICAL SITE “STOBI” R.MACEDONIA Filip Jovanoski, Igor Mitev, Dobriela R. Stavreva, Zlatko Ilijovski Teo( uyauHuku ucrpaxkyBama KAPTA HA IIOBPITIHMHA HA MOXO JUHCKOHTMHVYVMHMTET HA PEITIVBJIHMKA CEBEPHA MAKEJIOHMHJA ...
    ... KJIMMATCKHTE IIPOMEHH KAKO JIHJI OJI HCTPA)KVBAUKATA TIJJATDOOPMA BO TIIPOCTOPHOTO TIJJAHMPAMĐE Zlyuuua Tpnuesecka 4Hrenkoduk, Cotba Jlenumkos6a, R opou /{luo6, PEUURIE-ULI :BBEKGRGAWl]dCco . O OO O 0OOogDPOSOGOO O O OO 66 262 F ojnteMH HđoJaTotH H BeliITauKa I/IHTeJleI'eHHI/Ija USING THE iPhone ...

  • Отпад из процеса сагоревања угља као сировина за добијање елемената ретких земаља

    Бојан Земљак (2024)
    Због великог броја индустрија у којима се користе ови ресурси, глобална економија се у великој мери ослања на елементе ретких земаља. Елементи ретких земаља су есенцијална сировина — материјал за развој савремених технологија, али у односу на њихову огромну потражњу, њихово вађење је ограничено и повезано је са значајним утицајима на животну средину. Због њихове ограничене доступности, проблема који се јављају при процесима експлоатације, све више и више земаља почиње да тражи повољније могућности вађења елемената [REE] из секундарних ...
    Елементи ретких земаља, резерве, употреба, представници и методе опоравка елемената ретких земаља
    ... (2% 354564 r{c1!Nj 19ait{31%} 196747 |1%} SaaJ4t [%}- 13t [} [ Cekagcoa| 11421 80OT ON pp 407283 ı2N Gokngco - 87a89SSRt(1%} op spomtOwi dr per _ 400UC fN ebm a67t{Hs} i _ a — Tug 9N afv (Copper assa3t(ct%) Manganeza _ Tugtem 2000t (M6) ncon al 39400r(1%) 0 - i 1372 r(1a} Tumgmee ...
    ... [99] Andrews-Speed, P., Bleischwitz, R., Boersma, T., Johnson, C., Kemp, G. and VanDeveer, S.D., 2014. Want, waste or war?: The global resource nexus and the struggle Jor land, energy, food, water and minerals. Routledge. [100] Ballestrin, S., Low, R., Reynaud, G. and Crane, P., 2014. Honeymoon ...
    ... amplifier at communication wavelengths for integrated optics applications. SN Applied Sciences, 5(1), p.39. [141] Ayoub, 1., Sehgal, R., Sharma, V., Sehgal, R., Swart, H.C. and Kumar, V., 2023. Rare-Earth-Doped Ternary Oxide Materials for Down-Conversion and Upconversion. In Advanced Materials ...

  • Preparation, synthesis and characterization of nanometric Ca0.9Er0.1MnO3

    Tijana B. Vlašković, Bojana Laban, Maja Milošević, Maria Čebela, Vladimir Dodevski, Milena Rosić (2023)
    ... s available in open access, as well as the employees' publications. - The Repository is available at: www.dr.rgf.bg.ac.rs R Y O U N G S C I E N T I S T S IN C E R A M I C S UEĆ čS Ć ONFE RE NJCJE LONG SCIENTISTS, IN CERAMICS 15% ECerS CONFERENCE for YOUNG SCIENTISTS in CERAMICS ...

  • Neogena i kvartarna herpetofauna (Anura i Squamata) Srbije : doktorska disertacija

    Dragana D. Đurić (2019)
    U radu je prvi put opisan deo herpetofaune (Anura i Squamata) iz neogenih i kvartarnih lokaliteta Srbije. Obrađeni su lokaliteti Sibnica, Prebreza, Lazarevc, Vračević i Riđake, neogene starosti. Lokaliteti kvartarne starosti su pećine Mala i Velika Balanica, Pešturina, Hadži Prodanova, Baranica, Vrelska pećina i sedimentne ispune fisura u kamenolomima Venčac i Beočin. U radu je prikazana je taksonomska analiza herpetoloških ostataka. Pored taksonomske analize fosilnog materijala dat je kratak geografsko-geološki opis proučavanih lokaliteta, osnovne osteološke karakteristike anura i skvamata ...
    paleoherpetofauna, Anura, Squamata, kvartar, pleistocen, neogen, Srbija, paleoekologija, paleoklima
    ... Biton, R., Geff en, E., Vences, M., Cohen, O., Bailon, S., Rabinovich , R., Malka, Y., Oron, T., Boistel, R., Brumf eld, V. Gafny, S. 2013. The rediscovered Hula painted frog is a living fossil. Nature Communications, 4:1959. doi: 10.1038/ ncomms 2959 Biton, R., Boistel, R., Rabinovich, R., Gafny ...
    ... Prysjazhnjuk, V., Kovalenko, V., Krstić, N. 2000. On the terrestrial and fresh-water mollusks from Neogene of western Serbia, 219–224. In KARAMATA, S. & JANKOVIĆ, S. (eds.) Proceedings of the International Symposium “Geology and 143 Metallogeny of the Dinarides and the Vardar Zone”. The Department ...
    ... šta (Ost-Hercegovina). Glasnik zemaljskog Muzeja u Bosni i Hercegovini, 37: 125–135. Böhme G., R. Günther. 1979. Osteological studies in the European Water frogs Rana ridibunda, R. lessonae and R. “esculenta” (Anura, Ranidae). Mitteilungen aus dem zoologischen Museum in Berlin, 55(1): 203–215 ...

  • Одређивање оптималне производње дубинске пумпе на клипним шипкама

    Небојша Савић (2024)
    Дужи временски период током историје производње нафте, дубинске пумпе на клипним шипкама су први и у многим случајевима једини избор када су у питању механичке методе експлоатације. Правилан одабир сваког појединачног елемента система омогућава оптимизацију која са собом повлачи бенефите у виду повећавања ефикасности и смањења трошкова. Тренутно примењени систем дубинских пумпи на клипним шипкама на лежишту „Н“ обезбеђује стабилну производњу и реализацију годишњих планова производње без већих проблема. У овом раду је приказан начин оптимизације производње дубинским пумпама ...
    дубинска пумпа, оптимизација, производња, потисни вентил
    ... I k Epoj Hnekca /PS 23 / yA HsjaBMbyjeM a je 3aBpIHHH pa/jl TiOJi HaCJIOBOM ONA A — _ 204> ! ()r'—··\—–·;v&.'·'r—\·{··a·« E.XVASC. a Or _ r ) Ć (i4APO r O Oc OOp VOOOBMMMANKLC CiCOOTAC \R VJ{ ikic a LMWCI{W{Ca{y o • pe3yjrraT COIJCTBEHOr HCTpa);KHBauMKor palla, • a 3aBpMIHH paji y HeJMHHM ...
    ... orpeMe 3a yceaatbe: C-"Cup" r M - exaguug:H THH Mecro yceaamba mysme: A - spx B-amo T – aHo nokpeTEHH IIAp Tn nuH:iHH;ipa 3a wera.mHii K-Tim: W - ragax: a H - ojasasn 3 L - najnep 3a K-amum ca MeKIHM HaK0BalbeM: S - ragag 31 P - ojasas 38 Tim myyme: R - nHcepr T - ryGnHr TipeunHk ...
    ... Ipaduuku npuka3 peayamama 3a 0yuwiomuny HO16 Dynamornster Cards. 'Gearbox Torque Pkts 9000 //7 9000 B000) *\_/ 80000 """"""""""""""""""""" j r a; -r rugaj 7000 7000 2000 [ uuJ 800 3 a z 1ODG = 5000 500 H Downirake = FI H k i J 40000 š Pl EOM ELUJ 300 z i /_\ -20000 . eevdikai 200 ...

  • Laboratory testing of fly ash

    Miloš Šešlija, Aleksandra Rosić, Nebojša Radović, Milinko Vasić, Mitar Đogo, Milovan Jotić (2016)
    Fly ash is one of the most common waste materials created by burning of coal. It is composed of smaller particles, consisting mainly of aluminosilicate glass, mullite and quartz, which are collected by electrostatic separators (filter) of gaseous products arising from the combustion of coal. This paper presents the pozzolanic properties, mechanical properties, chemical and mineral composition of fly ash obtained in the combustion process in a power plant Nikola Tesla A (PPNT A) with the addition of a ...
    chemical composition, fly ash, mechanical properties, mineral properties, pozzolanic properties, X-ray diffraction
    ... ash according to the module R size ( ) ( )32 32 OFeMgOCaO AlOSiO R ++ + = (1) According to module R size, fly ash can be divided into: - silicate – calcium R < 2, - silicate R = 2 ÷ 6, - silicate – aluminum R > 6. 3. Classification of ...
    ... 16,10 8,74 MgO 0,64 4,39 2,64 SO3 0,66 3,27 1,76 S 0,26 1,31 0,70 Na2O 0,08 0,72 0,32 K2O 0,25 1,49 0,74 ( ) ( )32 32 module OFeMgOCaO AlOSiO R ++ + = 2,18 9,98 4,38 SiO2/Al2O3 1,92 6,27 2,66 2.2.1 The classification of fly ash on the basis of chemical composition There are several ...
    ... 1,16 8,74 MgO 3,01 2,83 2,64 SO3 0,85 0,54 1,76 S 0,33 0,21 0,70 Na2O 0,57 0,43 0,32 K2O 1,05 1,16 0,74 ( ) ( )32 32 module OFeMgOCaO AlOSiO R ++ + = 7,65 7,32 3,97 SiO2/Al2O3 2,36 2,33 2,57 Comparison of the chemical composition of fly ash taken in S1 and S2, with medium chemical ...

  • Uporedna analiza stabilnosti završnih kosina površinskog kopa „Veliki Krivelj“

    Mihajlo Topalović (2023)
    Površinski kop „Veliki Krivelj“ nalazi se u blizina grada Bora i u neposrednoj blizini sela Krivelj. Od 2018. godine je u vlasništvu kineske kompanije „Zijin“ koja ima udeo od 63% vlasništva celokupnog RTB-a Bor. Na površinskom kopu obavlja se masovna eksploatacija rude bakra opremom visokog kapaciteta. Za bušenje se koriste bušilice prečnika od 250 do 310 mm, a za utovar minirane rude i jalovine bageri čija je zapremina kašike 15 m3 i 22 m3. Za površinski kop „Veliki Krivelj“ ...
    stabilnost kosina, metoda konačnih elemenata, površinski kop, Veliki Krivelj, završna kosina

  • Analogue modelling of strain partitioning along a curved strike-slip fault system during backarc-convex orocline formation: Implications for the Cerna-Timok fault system of the Carpatho-Balkanides

    Nemanja Krstekanić, Ernst Willingshofer, Taco Broerse, Liviu Matenco, Marinko Toljić, Uroš Stojadinović (2021)
    analogno modelovanje, raspodela deformacija, geometrija indentera, Černa i Timok rasedni sistem
    ... University of Belgrade, Faculty of Mining and Geology, Belgrade, Serbia A R T I C L E I N F O Keywords: Analogue modelling Strain partitioning Strike-slip Indenter geometry Cerna and Timok faults system A B S T R A C T Large-scale strike-slip faults are associated with significant strain ...
    ... Bartolome, R., 2012. Thrust-wrench interference between major active faults in the Gulf of Cadiz (Africa-Eurasia plate boundary, offshore SW Iberia): tectonic implications from coupled analog and numerical modelling. Tectonophysics 548–549, 1–21. Rosas, F.M., Duarte, J.C., Schellart, W.P., Tomás, R., Grigorova ...
    ... southern Carpathians. Tectonophysics 297, 209–228. Schmid, S.M., Fügenschuh, B., Kounov, A., Matenco, L., Nievergelt, P., Oberhänsli, R., Pleuger, J., Schefer, S., Schuster, R., Tomljenović, B., Ustaszewski, K., van Hinsbergen, D.J.J., 2020. Tectonic units of the Alpine collision zone between Eastern ...

  • Serbian NER&Beyond: The Archaic and the Modern Intertwinned

    Branislava Šandrih Todorović, Cvetana Krstev, Ranka Stanković, Milica Ikonić Nešić (2021)
    U ovom radu predstavljamo srpski književni korpus koji se razvija pod okriljem COST Akcije „Distant Reading for European Literary History” CA16204. Koristeći ovaj korpus romana napisanih pre više od jednog veka, razvili smo i učinili javno dostupnim Sistem za prepoznavanje imenovanih entiteta (NER) obučen da prepozna 7 različitih tipova imenovanih entiteta, sa konvolucionom neuronskom mrežom (CNN), koja ima F1 rezultat od ≈91% na test skupu podataka. Ovaj model je dalje ocenjen na posebnom skupu podataka za evaluaciju. Završavamo poređenje ...
    ... used for the both training and evalu- ation (on average P = 75.1%, R = 62.6% and F1 = 68.3%), whilst for training on general te- xts, such as news data, and testing on literary texts the results were much poorer (on average P = 57.8%, R = 37.7% and F1 = 45.7%). 2NER&Beyond, http://nerbeyond.jerteh.rs/ ...
    ... the obtained annotations with the ones given in the test subset of the SrpELTeC-gold, we obtained the precision (P ), recall (R) and F1 scores displayed in Table 3. Type P R F1 PERS 0.953 0.936 0.944 ROLE 0.940 0.917 0.928 LOC 0.849 0.778 0.812 DEMO 0.781 0.758 0.769 ORG 0.903 0.368 0.523 WORK 0.324 ...
    ... l. Values of precision (P ), recall (R) and F1 scores over each entity are shown in the upper part of Figure 3. 5.2 SrpNER vs. SrpELTeC-eval The overall results for the SrpNER are di- splayed in the lower part of Table 5. Values of precision (P ), recall (R) and F1 scores over each entity are shown ...

  • Definition of criteria and alternatives for choosing the optimal mining method deposits when applying multi: Criteria optimization, Belgrade, June 2024

    Sanja Bajić, Dragoljub Bajić, Branko Gluščević, Radmila Gaćina, Josip Išek (2024)
    multi-criteria decision-making, definition of criteria, underground exploitation

  • Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study

    Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)
    Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...
    Pharmaceutical Science
    ... 1021/acs.jmedchem.7b01664. Kumar, S., Gokhale, R., Burgess, D.J., 2014. Sugars as bulking agents to prevent nano- crystal aggregation during spray or freeze-drying. Int. J. Pharm. 471 (1–2), 303-311. https://doi.org/10.1016//j.ijpharm.2014.05.060. L Remmele, R., Krishnan, S., J Callahan, W., 2012. Development ...
    ... strategies for nanocrystal preparations. Drug Deliv. 28, 19-36. https:// doi.org/10.1080/10717544.2020.1856224. Liao, X., Krishnamurthy, R., Suryanarayanan, R., 2007. Influence of processing conditions on the physical state of mannitol—implications in freeze-drying. Pharm. Res. 24 (2), 370–376. ...
    ... dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek ...