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747 items
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Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach
Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...... constant of 5.1 N/m. The cantilever driving frequency was around 150 kHz during the measurements. For the analysis of the taken topography and “error signal” AFM images, the software Image Analysis 2.2.0 (NT-MDT) was used. Differential Scanning Calorimetry (DSC) Around 2 mg of the dried samples of n ...
... to 50 mL/min. X-ray Powder Diffraction Analysis (XRPD) Nanocrystal dispersions with different particle sizes, corresponding suspension, and unprocessed DK-I-60-3 were investigated by X-ray powder diffraction (XRPD). Dispersions were centrifuged, and the analysis was performed on dried sediment. The ...
... respec- tively). 2.2.6. Statistical Analysis All measurements were performed in triplicate, and results were expressed as mean value ± SD, except in in vivo study where SEM was used instead of SD. After checking the normality of distribution, the statistical analysis involved Student’s t-test for two ...Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188
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Concepts for Improving Machine Learning Based Landslide Assessment
Miloš Marjanović, Mileva Samardžić Petrović, Biljana Abolmasov, Uroš Đurić. "Concepts for Improving Machine Learning Based Landslide Assessment" in Natural Hazards GIS-based Spatial Modeling Using Data Mining Techniques, Advances in Natural and Technological Hazards Research, volume 48, Springer Nature Switzerland AG 2019 (2019). https://doi.org/10.1007/978-3-319-73383-8_2
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Review: Methodological approaches and research techniques for addressing construction and remediation problems in karst reservoirs
Saša Milanović, Ljiljana Vasić (2021)Saša Milanović, Ljiljana Vasić. "Review: Methodological approaches and research techniques for addressing construction and remediation problems in karst reservoirs" in Hydrogeology Journal, Springer Science and Business Media LLC (2021). https://doi.org/10.1007/s10040-020-02280-1
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Distribution of major and trace elements in the Kovin lignite (Serbia)
Dragana Životić, Olga Cvetković, Predrag Vulić, Ivan Gržetić, Vladimir Simić, Konstantin Ilijević, Biljana Dojčinović, Suzana Erić, Bogdan Radić, Sanja Stojadinović, Snežana Trifunović (2019)geochemical and mineralogical study was performed on lignite samples from the Upper Miocene Kovin deposit, hosting three coal seams. The Kovin lignite is characterized by high moisture content, medium to high ash yield, medium to high sulphur content and a relatively low gross and net calorific value. The mineralogical composition, and major and trace element contents were determined by X-ray diffraction, scanning electron microscopy with energy dispersive Xray spectroscopy (SEM-EDS) analyses, and inductively coupled plasma optical emission spectrometry (ICP-OES). ...... IKACalorim eter adiabatic C 400, following the standard procedure (SRPS B.H8.318:1972, 1972). 3.4. X-ray diffraction (XRD) and SEM-EDS analysis Mineralogical analysis of fortytwo (without the 28/91 and 31/91 samples) ash samples, heated to 450°C was carried out using Table 1. The maceral composition ...
... (ISO) 1171 (1997): Methods for analysis and testing of coal and coke. Determination of ash content.– Internation al Organization for Standardization, Switzerland (10 p). INTERNATIONAL STANDARD ORGANIZATION (ISO) 7404–2 (2009): Methods for the Petrographic Analysis of Coals–Part 2: Methods of Preparing ...
... abstract). SRPS B.H8.317:1988, (1988): Methods of analysis of coal and coke Determination of volatile matter content.– Institute for Standardization of Serbia, Belgrade, Serbia, 6 p. (in Serbian). SRPS B.H8.318:1972, (1972): Methods of analysis of coal and coke Determination of gross calorific ...Dragana Životić, Olga Cvetković, Predrag Vulić, Ivan Gržetić, Vladimir Simić, Konstantin Ilijević, Biljana Dojčinović, Suzana Erić, Bogdan Radić, Sanja Stojadinović, Snežana Trifunović. "Distribution of major and trace elements in the Kovin lignite (Serbia)" in Geologia Croatica, Croatian Geological Survey (2019). https://doi.org/10.4154/gc.2019.06
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Rangiranja bagera za njihovu revitalizaciju primenom višekriterijumske analize
Obzirom da je na našim površinskim kopovima trenutno u eksploataciji veći broj rotornih bagera sa sličnim tehničkim karakteristikama i približno istom starošću postavlja se pitanje kako rangirati bagere, i kojim redom da se izvrši njihova revitalizacija. Za ocenu stanja i rangiranje ovako velikog broja bagera najpogodnije se pokazalo korišćenje višekriterijumskih metoda sa višeatributnom ocenom, odnosno bodovanje referentnih indikatora stanja bagera na osnovu ekspertske ocene. U ovom radu prikazan je metodološki pristup koji je korišćen prilikom izrade Studije «Produžetak radnog ...... feasibility study: Increasing of equipment work life in EPS open pit mines. KEY WORDS: BUCKET WHEEL EXCAVATORS, REVITALIZATION, RANKING, MULTICRITERIA ANALYSIS 1. UVOD Na svim površinskim kopovima u Srbiji se primenjuje kontinualna tehnika eksploatacije, tj. primena BTO sistema na otkopavanju jalovine ...Ivan Obradović, Dragan Ignjatović, Ranka Stanković, Ljiljana Ivković. "Rangiranja bagera za njihovu revitalizaciju primenom višekriterijumske analize" in MAREN 2006, Međunarodni simpozijum Mehanizacija i automatizacija u rudarstvu i energetika, zbornik radova, septembar 2006, Beograd, Univerzitet u Beogradu-Rudarsko-geološki fakultet (2006)
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Uticaj ekstremnih procesa na rizike površinske eksploatacije
Nepredvidivi ekološki negativni slučajni procesi mogu uticati na geo-tehnički sistem pri površinskoj eksploataciji ležišta mineralnih sirovina, što u velikoj meri uvećava rizike i ugrožava realizaciju proizvodnje. Kvantitativna analiza sa proračunom verovatnoća pojava ovakvih ekstremnih događaja i procenom odgovarajućih ekonomskih posledica, posebno u uslovima globalnih klimatskih promena, omogućava definisanje rizika i optimizaciju parametara sistema površinske eksploatacije.Natalija Pavlović, Tomislav Šubaranović, Dragan Ignjatović. "Uticaj ekstremnih procesa na rizike površinske eksploatacije" in 15. međunarodna konferencija o površinskoj eksploataciji OMC 2022, Zlatibor, 12.-15.10.2022., Jugoslovenski komitet za površinsku eksploataciju (2022)
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Temperature induced evolution of nanostructured Ni0.9Zn0.1O
Kremenović Aleksandar, Antić Bratislav, Vučinić-Vasić Milica, Colomban Philippe, Jovalekić Čedomir, Bibić Nataša, Kahlenberg Volker, Leoni Matteo (2010)The crystal structure and microstructure of as-prepared and annealed Ni0.9Zn0.1O were refined at room temperature in both the Fm (3) over barm and R (3) over barm space groups. It is shown that below the Neel point (458 K), where magnetic ordering triggers the presence of a trigonal strain, the common usage of a higher-symmetry non-admissible space group for crystal structure and microstructure analysis via the Rietveld method may result in both an incorrect structure description and incorrect microstructure ...Kremenović Aleksandar, Antić Bratislav, Vučinić-Vasić Milica, Colomban Philippe, Jovalekić Čedomir, Bibić Nataša, Kahlenberg Volker, Leoni Matteo. "Temperature induced evolution of nanostructured Ni0.9Zn0.1O" in Journal of Applied Crystallography no. 43, Denmark: Blackwell Munksgaard (2010). https://doi.org/10.1107/S0021889810019163
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Malathion-induced inhibition of human plasma cholinesterase studied by the fluorescence spectroscopy method
The in vitro effect of technical grade malathion was assessed via the kinetic parameters of human plasma butyrylcholinesterase (BChE) using N-methylindoxyl acetate as a substrate for BChE. An inhibitor kinetics study demonstrated the existence of a biphasic inhibition curve, indicating high- and low-affinity binding sites of malathion. The IC50 values as calculated from the experimental inhibition curves were 1.33 × 10–9 and 1.48 × 10–5 M for the high- and low-affinity binding sites, respectively; Hill’s analysis gave 1.29 × ...V. M. Pavelkić, K. S. Krinulović, J. Z. Savić, M. A. Ilić. "Malathion-induced inhibition of human plasma cholinesterase studied by the fluorescence spectroscopy method" in Russian Journal of Physical Chemistry A, Pleiades Publishing Ltd (2008). https://doi.org/10.1134/S0036024408050312
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Spatial assessment of the areas sensitive to degradation in the rural area of the municipality Čukarica
Nature and Landscape Conservation, Soil Science, Agronomy and Crop Science, Water Science and TechnologyNatalija Momirović, Ratko Kadović, Veljko Perović, Miloš Marjanović, Aleksandar Baumgertel. "Spatial assessment of the areas sensitive to degradation in the rural area of the municipality Čukarica" in International Soil and Water Conservation Research, Elsevier BV (2019). https://doi.org/10.1016/j.iswcr.2018.12.004
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Ostvarivanje dobiti pri uvođenju sistema agregatnih zamena na osnovnoj rudarskoj mehanizaciji površinskih kopova EPS
Jedan od osnovnih zadataka na površinskim kopovima uglja je ostvarivanje zadovoljavajućeg vremenskog i kapacitetnog iskorišćenja kontinualnih sistema. Da bi se to postiglo, neophodno je izvršiti izmene u postojećoj strategiji održavanja. Preduslov je uvođenje agregatne zamene vitalnih delova na rudarskim mašinama. Benefiti su višestruki. Očekivani rezultati ovakvog pristupa su: smanjenje zastoja i povećanje vremena rada; direktne materijalne uštede; bolja organizacija rada; racionalizaciju radioničkih i magacinskih kapaciteta; povećanje vrednosti mašina. Da bi se uvela agregatna zamena neophodne su investicije za nabavku ...Predrag Jovančić, Ignjatović Dragan, Đenadić Stevan. "Ostvarivanje dobiti pri uvođenju sistema agregatnih zamena na osnovnoj rudarskoj mehanizaciji površinskih kopova EPS" in X Međunarodna konferencija UGALJ, Zlatibor, Srbija, 13-16. Oktobar 2021., Jugoslovenski komitet za površinsku eksploataciju (2021)
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Definition of criteria and alternatives for choosing the optimal mining method deposits when applying multi: Criteria optimization, Belgrade, June 2024
Sanja Bajić, Dragoljub Bajić, Branko Gluščević, Radmila Gaćina, Josip Išek. "Definition of criteria and alternatives for choosing the optimal mining method deposits when applying multi: Criteria optimization, Belgrade, June 2024" in Podzemni radovi, Beograd, jun 2024, Centre for Evaluation in Education and Science (CEON/CEES) (2024). https://doi.org/10.5937/podrad2444071B
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Linear-motor plunger pump increases lifting efficiency
Bojan Martinović, Dušan Đekić, Dušan Danilović, Pavel Isaev. "Linear-motor plunger pump increases lifting efficiency" in Oil & Gas Journal (2022)
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Environmental Noise Impact Assessment for Large-Scale Surface Mining Operations in Serbia
Noise emissions are a significant environmental impact caused by the mining industry in all technological phases of surface mining, mineral processing, and waste disposal. This paper presents the role of noise impact assessment and control in large-scale surface mining operations. Mine planning develops the model of mining operations, ore excavation, and waste dumping scheduling and processing rates, including spatial distribution of mining activities. Such a level of mine planning requires an environmental impact assessment study. This can be achieved ...Uros Pantelic, Petar Lilic, Aleksandar Cvjetic, Nikola Lilic. "Environmental Noise Impact Assessment for Large-Scale Surface Mining Operations in Serbia" in Sustainability, MDPI AG (2023). https://doi.org/10.3390/su15031798
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A Data Driven Approach for Raw Material Terminology
Olivera Kitanović, Ranka Stanković, Aleksandra Tomašević, Mihailo Škorić, Ivan Babić, Ljiljana Kolonja (2021)The research presented in this paper aims at creating a bilingual (sr-en), easily searchable, hypertext, born-digital, corpus-based terminological database of raw material terminology for dictionary production. The approach is based on linking dictionaries related to the raw material domain, both digitally born and printed, into a lexicon structure, aligning terminology from different dictionaries as much as possible. This paper presents the main features of this approach, data used for compilation of the terminological database, the procedure by which it has ...sirovine, rudarstvo, terminologija, rečnik, terminološka aplikacija, mobilna aplikacija, digitizacija, leksički podaci, korpusi, otvoreni povezani podaci... followed by adding new Serbian terms to general lexica dictionaries, as well as adding bilingual terms. Dictionary development is relying on corpus analysis, details of which are also presented. Usage examples, collocations and concordances play an important role in raw material terminology, and have also ...
... followed by adding new Serbian terms to general lexica dictionaries, as well as adding bilingual terms. Dictionary development is relying on corpus analysis, details of which are also presented. Usage examples, collocations and concordances play an important role in raw material terminology, and have also ...
... technology offer the possibility of changing the face of lexicographical support in a mobile environment, from a pedagogical perspective [6]. Big data analysis methods have opened new possibilities for analyzing corpora, which contain large amounts of textual data. Thus, for example, Chen et al. [7] propose ...Olivera Kitanović, Ranka Stanković, Aleksandra Tomašević, Mihailo Škorić, Ivan Babić, Ljiljana Kolonja. "A Data Driven Approach for Raw Material Terminology" in Applied Sciences, MDPI AG (2021). https://doi.org/10.3390/app11072892
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Structural and geochronological constraints from the Drina-Ivanjica thrust sheet (Western Serbia): implications for the Cretaceous–Paleogene tectonics of the Internal Dinarides
Kristof Porkoláb, Szilvia Kövér, Zsolt Benkó, Gabor Héja, Melinda Fialowski, Balázs Soós, Nataša Gerzina Spajić, Nevenka Đerić, László Fodor (2019)Internal Dinarides, Drina-Ivanjica thrust sheet, Deformation history, K–Ar dating, Obduction, Structural analysis... Carpathian-Dinaridic realm. Keywords Internal Dinarides · Drina-Ivanjica thrust sheet · Deformation history · K-Ar dating · Obduction · Structural analysis Editorial handling: V. Cvetkovic. Institute for Nuclear Research of the Hungarian Academy of Kristof Porkolab Sciences, 18/c Bem tćr, Debrecen ...
... gin of Triassic sequences outcropping necar the Paleozoic core of the Drina-Ivanjica thrust sheet. Mapping of fault patterns and paleostress analysis furthermore reveal char- acteristics of the Paleogene-Neogene tectonic evolution of the area. 2 Geological setting The Dinarides are a mountain ...
... for 60 independent determi- nations. All isotope measurements were corrected by the atmospheric “ČAr/”"Ar ratios determined on the day of the analysis. The accuracy and reproducibility of the isotope ratio measurements were periodically controlled by the Rodina 2/65 internal standard for which ...Kristof Porkoláb, Szilvia Kövér, Zsolt Benkó, Gabor Héja, Melinda Fialowski, Balázs Soós, Nataša Gerzina Spajić, Nevenka Đerić, László Fodor. "Structural and geochronological constraints from the Drina-Ivanjica thrust sheet (Western Serbia): implications for the Cretaceous–Paleogene tectonics of the Internal Dinarides" in Swiss Journal of Geosciences (2019)
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Determining the Availability of Continuous Systems at Open Pits Applying Fuzzy Logic
This work presents a model for determining the availability of continuous systems at open pits by applying fuzzy logic and fuzzy inference systems. The applied model was formed by the synthesis of independent partial indicators of availability. The model is based on an expert system for assessing the availability of continuous mining systems. The availability of the system, as a complex state parameter, is decomposed into the partial indicators, reliability, and convenience of maintenance, and the fuzzy compositions, used ...системи, континуални систем експоатације, површински коп, рударство, расположивост, фази логика, max–min композиција, min–max композицијаMiljan Gomilanović, Miloš Tanasijević, Saša Stepanović. "Determining the Availability of Continuous Systems at Open Pits Applying Fuzzy Logic" in Energies, MDPI AG (2022). https://doi.org/10.3390/en15186786
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Design of a sucker rod pumping system
Ana Ponoćko (2024)For a long time in the history of oil production, sucker rod pumps have been the first and in many cases the only choice when it comes to mechanical extraction methods. Proper selection of each individual element of the system enables optimization, which entails benefits in the form of increased efficiency and reduced costs. The first part of the paper presents the underground and surface equipment of the rod pump and describes the operation of the entire system. The ...... paper presents the underground and surface equipment of the rod pump and describes the operation of the entire system. The second part involves an analysis and calculations using the "RODSTAR", "QRod" and "Prosper" software, which will define differences in calculations between software for Sucker ...
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... paper presents the underground and surface equipment of the rod pump and describes the operation of the entire system. The second part involves an analysis and calculations using the "RODSTAR", "QRod" and "Prosper" software, which will define differences in calculations between software for Sucker ...Ana Ponoćko. Design of a sucker rod pumping system, 2024
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Numerical Modeling and Simulation of the Effectiveness of Groundwater Source Protection Management Plans: Riverbank Filtration Case Study in Serbia
The paper describes the establishment and testing of an algorithm for developing sustainable management plans associated with groundwater source protection against potential pollutants and discusses the effectiveness of individual systems. The applied methodology pertains to groundwater resource management, particularly those cases that involve riverbank filtration. Namely, groundwater (numerical) modeling is employed to examine the groundwater regime and balance, as well as to create protection systems and illustrate their effectiveness. Particle tracking analysis is used to study pollutants’ travel and ...Dušan Polomčić, Dragoljub Bajić, Bojan Hajdin, Dragan Pamučar. "Numerical Modeling and Simulation of the Effectiveness of Groundwater Source Protection Management Plans: Riverbank Filtration Case Study in Serbia" in Water, MDPI AG (2022). https://doi.org/10.3390/w14131993
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Development of the Cost-Based Model for Monitoring the Lifetime of the Earth Moving Machines
This paper presents the model for the identification of reference points on the lifetime curve of engineering systems. This curve commonly represents the increase and decline of failure in relation to time. A direct correlation between failure rate and costs is assumed in this paper, therefore, statistical and empirical analysis of costs provided reference points. This approach is used for positioning stages of the engineering system’s lifetime with a minimal number of failures and costs, regardless of whether these ...Electrical and Electronic Engineering,Industrial and Manufacturing Engineering, Control and Optimization, Mechanical Engineering, Computer Science (miscellaneous), Control and Systems EngineeringUgljesa Bugarić, Milos Tanasijević, Stevan Djenadić, Dragan Ignjatović, Ivan Janković. "Development of the Cost-Based Model for Monitoring the Lifetime of the Earth Moving Machines" in Machines, MDPI AG (2022). https://doi.org/10.3390/machines10110995
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Structural and microstructural study of brookite based TiO2 nanocomposites with carbon black (C)
Structural and microstructural properties of TiO2-based nanocomposites with carbon black (C), synthesized by sol-gel-hydrothermal method, have been studied by XRPD and Raman scattering. Detailed size-strain analyses of XRPD and Raman scattering results are presented in order to investigate the influence of C content on brokite and anatase phase formation. The XRPD size-strain analyses have resulted in reliable structure and microstructure results for both anatase and brookite and their relative abundance ratio has been refined by Rietveld method. The brookite ...Aleksandar Kremenović, Mirjana Grujić-Brojčin, Nataša Tomić, Maja Šćepanović. "Structural and microstructural study of brookite based TiO2 nanocomposites with carbon black (C)" in The European Powder Diffraction Conference (EPDIC) Book of Abstracts, Šibenik, 31 May - 3 June 2022, EPDIC (2022)