Претрага
101 items
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Polymorphism and photoluminescence properties of K3ErSi2O7
alkalni silikati elemenata retkih zemalja, silikati lantanoida, polimorfizam, fotoluminescencija, kristalna strukturaPredrag Dabić, Marko G. Nikolić, Sabina Kovač, Aleksandar Kremenović. "Polymorphism and photoluminescence properties of K3ErSi2O7" in Acta Crystallographica Section C Structural Chemistry, International Union of Crystallography (IUCr) (2019). https://doi.org/10.1107/S2053229619011926
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Differently shaped nanocrystalline (Fe, Y)3O4 and its adsorption efficiency toward inorganic arsenic species
Biljana P Dojčinović, Boštjan Jančar, Lotfi Bessais, Aleksandar Kremenović, Nataša P Jović-Jovičić, Predrag T Banković, Dalibor M Stanković, Miloš Ognjanović, Bratislav V Antić (2019)Herein we report effects of partial substitution of Fe3+ by Y3+ in magnetite (Fe3O4) on morphology and inorganic arsenic species adsorption efficiency of the Fe3−xYxO4 nanoparticles formed. The series of Fe3−xYxO4 (x=0.00, 0.042 and 0.084, labeled as Y00, Y05 and Y10, respectively) was synthesized using co-precipitation followed by microwave-hydrothermal treatment (MW) at 200°C. With increase of yttrium content(xvalue), both the morphological inhomogeneity of the samples and the fraction of spinel nanorods as compared to spinel pseudospherical particles increased. By ...Biljana P Dojčinović, Boštjan Jančar, Lotfi Bessais, Aleksandar Kremenović, Nataša P Jović-Jovičić, Predrag T Banković, Dalibor M Stanković, Miloš Ognjanović, Bratislav V Antić. "Differently shaped nanocrystalline (Fe, Y)3O4 and its adsorption efficiency toward inorganic arsenic species" in Nanotechnology, IOP Publishing (2019). https://doi.org/10.1088/1361-6528/ab3ca2
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Adsorption and degradation of some psychiatric drugs by sol-gel synthesized titania-based photocatalysts: influence of tungsten and sodium content
Nina L. Finčur, Maja J. Šćepanović, Mirjana Grujić-Brojčin, Biljana F. Abramović, Jugoslav B. Krstić, Aleksandar Kremenović, Tatjana Srećković, Aleksandar Golubović (2019)Mesoporous anatase nanopowders were doped with 0.05−0.5 mol% of W6, in order to obtain more efficient photocatalyst than TiO2 Degussa P25 in the degradation of amitriptyline (AMI) under simulated solar irradiation (SSI). Dominant XRPD peaks were ascribed to anatase phase, with additional peaks which could correspond to brookite, TiO2 bronze and sodium titanate, Na2Ti9O19. The Raman scattering measurements have confirmed anatase as dominant phase, with broad Raman feature at ~270 cm−1 possibly related to Ti–O–Na stretching vibration. All W-doped ...Sol-gel synthesis, Doped titania nanopowders, XRPD, Raman spectroscopy, Adsorption and photocatalytic degradation, Psychiatric drugsNina L. Finčur, Maja J. Šćepanović, Mirjana Grujić-Brojčin, Biljana F. Abramović, Jugoslav B. Krstić, Aleksandar Kremenović, Tatjana Srećković, Aleksandar Golubović. "Adsorption and degradation of some psychiatric drugs by sol-gel synthesized titania-based photocatalysts: influence of tungsten and sodium content" in Journal of Sol-Gel Science and Technology, Springer Science and Business Media LLC (2019). https://doi.org/10.1007/s10971-019-04925-4
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Low-temperature phase transition and magnetic properties of K3YbSi2O7
Predrag Dabić, Volker Kahlenberg, Biljana Krüger, Marko Rodić, Sabina Kovač, Jovan Blanuša, Zvonko Jagličić, Ljiljana Karanović, Václav Petříček, Aleksandar Kremenović (2021)alkalni silikati elemenata retkih zemalja, fazni prelazi, magnetne karakteristike, razdvajanje kristalnog polja, silikati lantanica... co-authors (2015) reported a low- temperature phase transition in NaGd0.99Eu0.01SiO4. Its crystal structure was solved from single-crystal X-ray diffraction (SCXRD) data collected at 100 K and described in orthor- hombic space group Pnma. Lowering the temperature resulted in a change to a body-centred ...
... Prismatic colourless single crystals up to 500 mm in size were observed, embedded in a polycrystalline matrix of KF. 2.2. Single-crystal X-ray diffraction measurement, structure solution and refinement Single-crystal XRD data were collected for crystal 1 at ambient conditions (298 K) and at low ...
... and co-authors (2015) reported a low- temperature phase transition in NaGdo99Eup,9; SiOx. Its crystal structure was solved from single-crystal X-ray diffraction (SCXRD) data collected at 100 K and described in orthor- hombic space group Pnma. Lowering the temperature resulted in a change to a body-centred ...Predrag Dabić, Volker Kahlenberg, Biljana Krüger, Marko Rodić, Sabina Kovač, Jovan Blanuša, Zvonko Jagličić, Ljiljana Karanović, Václav Petříček, Aleksandar Kremenović. "Low-temperature phase transition and magnetic properties of K3YbSi2O7" in Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, International Union of Crystallography (IUCr) (2021). https://doi.org/10.1107/S2052520621006077
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Temperature induced evolution of nanostructured Ni0.9Zn0.1O
Kremenović Aleksandar, Antić Bratislav, Vučinić-Vasić Milica, Colomban Philippe, Jovalekić Čedomir, Bibić Nataša, Kahlenberg Volker, Leoni Matteo (2010)The crystal structure and microstructure of as-prepared and annealed Ni0.9Zn0.1O were refined at room temperature in both the Fm (3) over barm and R (3) over barm space groups. It is shown that below the Neel point (458 K), where magnetic ordering triggers the presence of a trigonal strain, the common usage of a higher-symmetry non-admissible space group for crystal structure and microstructure analysis via the Rietveld method may result in both an incorrect structure description and incorrect microstructure ...Kremenović Aleksandar, Antić Bratislav, Vučinić-Vasić Milica, Colomban Philippe, Jovalekić Čedomir, Bibić Nataša, Kahlenberg Volker, Leoni Matteo. "Temperature induced evolution of nanostructured Ni0.9Zn0.1O" in Journal of Applied Crystallography no. 43, Denmark: Blackwell Munksgaard (2010). https://doi.org/10.1107/S0021889810019163
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Asbestos-Based Pottery from Corsica: The First Fiber-Reinforced Ceramic Matrix Composite
Asbestos-containing pottery shards collected in the northeast of Corsica (Cap Corse) and dating from the 19th century, or earlier, have been analyzed by SEM-EDS, XRPD, FTIR and Raman microspectroscopy. Blue (crocidolite) and white (chrysotile) asbestos fiber bundles are observed in cross-sections. Most of the asbestos is partly or totally dehydroxylated, and some transformation to forsterite is observed to occur, indicative of a firing above 800 C. Examination of freshly fractured pieces shows a nonbrittle fracture with fiber pull-out, consistent with ...... structural and thermoelastic behaviour of mantle orthopyroxene: An in situ neutron powder diffraction study. Phys. Chem. Miner. 2007, 34,185—200. [CrossRef] National Bureau of Standards (USA). Standard x-ray diffraction powder patterns. Monographs 1967, 255, 17. Reynolds, R., Jr.; DiStefano, M.; Lahann ...
... Ambrosi, E.; Ngo, A.-T.; Lu, T.-A.; Feng, X.-L.; Chen, S.; Choi, C.-L. Comparative analysis of wucai Chinese porcelains using, mobile and fixed Raman microspectrometers. Ceram. Imf. 2017, 43, 14244—14256. [CrossRef] PDXL 2. Integrated X-Ray Powder Diffraction Sofhuare, Version 2.8.3.0; Rigaku Corporation: ...
... Evans, B.W.; Yang, H.-X. Fe-Mg order-disorder in tremolite-actinolite-ferro-actinolite at ambient and high temperature. Am. Mineral. 1998, 83, 458-475. [CrossRet] Dichicco, M.C.; de Bonis, A.; Mongelli, G.; Rizzo, G.; Sinisi, R. ı-Raman spectroscopy and X-ray diffraction of asbestos” minerals ...Philippe Colomban, Aleksandar Kremenović. "Asbestos-Based Pottery from Corsica: The First Fiber-Reinforced Ceramic Matrix Composite" in Materials, MDPI AG (2020). https://doi.org/10.3390/ma13163597
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Structural and microstructural study of brookite based TiO2 nanocomposites with carbon black (C)
Structural and microstructural properties of TiO2-based nanocomposites with carbon black (C), synthesized by sol-gel-hydrothermal method, have been studied by XRPD and Raman scattering. Detailed size-strain analyses of XRPD and Raman scattering results are presented in order to investigate the influence of C content on brokite and anatase phase formation. The XRPD size-strain analyses have resulted in reliable structure and microstructure results for both anatase and brookite and their relative abundance ratio has been refined by Rietveld method. The brookite ...Aleksandar Kremenović, Mirjana Grujić-Brojčin, Nataša Tomić, Maja Šćepanović. "Structural and microstructural study of brookite based TiO2 nanocomposites with carbon black (C)" in The European Powder Diffraction Conference (EPDIC) Book of Abstracts, Šibenik, 31 May - 3 June 2022, EPDIC (2022)
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Synthesis of MnCo2O4 nanoparticles as modifiers for simultaneous determination of Pb(II) and Cd(II)
The porous spinel oxide nanoparticles, MnCo2O4, were synthesized by citrate gel combustion technique. Morphology, crystallinity and Co/Mn content of modified electrode was characterized and determined by Fourier transform infra-red spectroscopy (FT-IR), scanning electron microscopy (SEM), energy dispersive spectrometry (EDS), X-ray diffraction pattern analysis (XRD), simultaneous thermogravimetry and differential thermal analysis (TG/DTA). Nanoparticles were used for modification of glassy carbon electrode (GCE) and new sensor was applied for simultaneous determination of Pb(II) and Cd(II) ions in water samples with the ...Vesna Antunović, Marija Ilić, Rada Baošić, Dijana Jelić, Aleksandar Lolić. "Synthesis of MnCo2O4 nanoparticles as modifiers for simultaneous determination of Pb(II) and Cd(II)" in PLOS ONE (2019). https://doi.org/10.1371/journal.pone.0210904
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A new copper(II) arsenate, Na2Cu3(AsO3OH)4·4H2O containing discrete [Cu3O12]18− units: Synthesis, crystal structure and magnetic properties
Single crystals of the new disodium tricopper(II) tetrakis(hydrogenarsenate(V)) tetrahydrate, Na2Cu3(AsO3OH)4·4H2O were grown under hydrothermal conditions. The compound was characterized by room-temperature single-crystal X-ray diffraction, SEM-EDS analysis, Raman spectroscopy and magnetic susceptibility measurements. Na2Cu3(AsO3OH)4·4H2O represents a new layered structure-type [space group P21/c, a = 8.7089(17), b = 9.7452(19), c = 9.3353(19) Å, β = 92.63(3)°, V = 791.4(3) Å3, Z = 4]. The layers are normal to [100] and are composed of the isolated Cu3O12 units interconnected by AsO3OH coordination ...Na2Cu3(AsO3OH)4•4H2O, хидротермална синтеза, кристална структура, хидрирани хидрокси-арсенати, магнетна својстваTamara Đorđević, Ljiljana Karanović, Zvonko Jagličić. "A new copper(II) arsenate, Na2Cu3(AsO3OH)4·4H2O containing discrete [Cu3O12]18− units: Synthesis, crystal structure and magnetic properties" in Journal of Solid State Chemistry, Elsevier BV (2018). https://doi.org/10.1016/j.jssc.2018.05.024
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Novel cerium and praseodymium doped phosphate tungsten bronzes: Synthesis, characterization, the behavior in the Briggs-Rauscher reaction and photoluminescence properties
Tijana Maksimović, Pavle Tančić, Jelena Maksimović, Dimitrije Mara, Marija Ilić, Rik Van Deun, Ljubinka Joksović, Maja Pagnacco (2023)Due to the interesting and potentially useful properties, phosphate tungsten bronzes are constantly being studied and attract a lot of attention. In the present work, two different metallic elements, belonging to the group of rare-earth metals, cerium and praseodymium, were used as a dopants for phosphate tungsten bronzes. Novel cerium and praseodymium doped phosphate tungsten bronzes were successfully synthesized and further characterized by thermal analyses, Fourier-transform infrared spectroscopy, X-ray powder diffraction, scanning electron microscopy with energy-dispersive X-ray spectrometer and ...Electrical and Electronic Engineering, Atomic and Molecular Physics and Optics, Electronic, Optical and Magnetic Materials, Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, SpectroscopyTijana Maksimović, Pavle Tančić, Jelena Maksimović, Dimitrije Mara, Marija Ilić, Rik Van Deun, Ljubinka Joksović, Maja Pagnacco. "Novel cerium and praseodymium doped phosphate tungsten bronzes: Synthesis, characterization, the behavior in the Briggs-Rauscher reaction and photoluminescence properties" in Optical Materials, Elsevier BV (2023). https://doi.org/10.1016/j.optmat.2023.114125
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A new polymorph of Ba(AsO3OH): Synthesis, crystal structure and vibrational spectra
Tamara Đorđević, Ljiljana Karanović (2010)A new monoclinic polymorph of Ba(AsO3OH) was synthesized under hydrothermal conditions. It represents a previously unknown structure type. Its crystal structure was determined from a racemic twin using single-crystal X-ray diffraction data collected at 120 and 293 K [space group P21, a=7.2149(14)/7.2370(2), b=7.7028(15)/7.7133(2), c=21.7385(43)/21.8079(5) Å, β=95.95(3)/96.073(1)1, V=1201.6(4)/1210.51(5) Å3, Z=12]. The crystal structure of P21-Ba(AsO3OH) has a layered character and is built up of four types of regularly alternating layers parallel to (0 0 1). Every AsO3OH tetrahedron is chelating to two Ba atoms and ...Ba(AsO3OH), хидротермална синтеза, структурна анализа монокристала, Раманска спектроскопија, инфрацрвена спектроскопија, водоничне везе, хидрогенарсенати земноалкалних металаTamara Đorđević, Ljiljana Karanović. "A new polymorph of Ba(AsO3OH): Synthesis, crystal structure and vibrational spectra" in Journal of Solid State Chemistry, Elsevier BV (2010). https://doi.org/10.1016/j.jssc.2010.09.027
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Refinement of waste phosphogypsum from Prahovo, Serbia: characterization and assessment of application in civil engineering
Josip Išek, Lazar Kaluđerović, Nikola Vuković, Maja Milošević, Ivana Vukašinović, Zorica Tomić (2020)... induct- ively coupled plasma optical emission spectrometry, X-ray diffraction and scanning electron microscopy with energy-dispersive spec- trometry. The activity concentrations of #U, 5U, **Ra, *!"pb, Th and “K were investigated using Y-ray spectrometry. Based on the activity concentration results ...
... was performed in an Advanced Microwave Digestion System (ETHOS 1, Milestone, Italy) using an HPR-1000/10S high-pressure segmented rotor. X-ray diffraction measurements Mineralogical composition was determined using a Philips PW 1710 automated diffractometer, using: Cu-Ko: radiation (, = 1.54184 ...
... of Technology, Cambridge, MA, USA. Roode Q.I. & Strydom C.A. (1999) The characterization of phosphogypsum and gypsum-brushite mixtures by X-ray diffraction, thermogravimetric and differential scanning calorimetric techniques. Comcrete Sciemce and Engineering, 1, 222–227. RS Official Gazette (2014) ...Josip Išek, Lazar Kaluđerović, Nikola Vuković, Maja Milošević, Ivana Vukašinović, Zorica Tomić. "Refinement of waste phosphogypsum from Prahovo, Serbia: characterization and assessment of application in civil engineering" in Clay Minerals, Cambridge University press (2020). https://doi.org/10.1180/clm.2020.11
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Influence of Post-Synthesis Treatments on the Properties of Brushite/Monetite Powders
Željko Radovanović, Lidija Radovanović, Aleksandar Kremenović, Đorđe Janaćković, Rada Petrović (2022)Dicalcium phosphate (DP) materials, of which brushite and monetite were the most known, have been intensively studied for several decades because of excellent resorptive and osteoconductive properties that can satisfy the requirements needed for various medical applications, such as bone cements, coatings of metallic implants and bone grafts ...Željko Radovanović, Lidija Radovanović, Aleksandar Kremenović, Đorđe Janaćković, Rada Petrović. "Influence of Post-Synthesis Treatments on the Properties of Brushite/Monetite Powders " in Second International Conference on Electron Microscopy of Nanostructures ELMINA 2022, August 22nd–26th, 2022, Belgrade, Serbia, Serbian Academy of Sciences and Arts Knez Mihailova 35, 11000 Belgrade, Serbia (2022)
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Curcumin nanonization using an alternative small-scale production unit: selection of proper stabilizer applying basic physicochemical consideration and biological activity assessment of nanocrystals
Ines Nikolić, Jelena Antić-Stanković, Dragana Božić, Danijela Ranđelović, Bojan Marković, Dominique Jasmin Lunter, Aleksandar Kremenović, Miroslav Savić, Snežana Savić (2020)As the number of poorly soluble drugs is increasing, nanocrystals have become very interesting due to wide range of application possibilities. Curcumin was used as a model active ingredient in this work. Even though it has many proven positive effects, due to its physicochemical issues, its possibilities have not been fully exploited. The goal of this work was to select optimal conditions for a top-down method for curcumin nanosuspension production, and to perform their comprehensive characterization applying complementary methodologies: ...Ines Nikolić, Jelena Antić-Stanković, Dragana Božić, Danijela Ranđelović, Bojan Marković, Dominique Jasmin Lunter, Aleksandar Kremenović, Miroslav Savić, Snežana Savić. "Curcumin nanonization using an alternative small-scale production unit: selection of proper stabilizer applying basic physicochemical consideration and biological activity assessment of nanocrystals" in Review on advanced materials science, Walter de Gruyter GmbH (2020). https://doi.org/10.1515/rams-2020-0043
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Sinteza i karakterizacija vanadata alkalnih metala sa elementima retkih zemalja
Anđela Jovanović (2024)Predmet i cilj pisanja ovog rada su sinteza i karakterizacija vanadata alkalnih metala sa elementima retkih zemalja. Prilikom ovih istraživanja, ispitivan je sistem REE2O3–V2O5–KF, gde REE predstavlja trovalentni katjon izabranih elemenata retkih zemalja (Y, Sm, Eu, Gd, Er, Yb). Ovo istraživanje bazirano je na sintezi kristala, nakon čega su dobijeni kristali posmatrani pod binokularnom lupom, analizirani metodom rendgenske difrakcije na polikristalnom materijalu (XRPD) i metodom skenirajuće elektronske mikroskopije sa energetsko-disperzivnom spektroskopijom (SEM-EDS), kako bi se utvrdile karakteristike dobijenih kristala. ...elementi retkih zemalja, sinteza kristala metodom fluksa, vanadati alkalnih metala, rendgenska difrakcija, SEM-EDS metodaAnđela Jovanović. Sinteza i karakterizacija vanadata alkalnih metala sa elementima retkih zemalja, 2024
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Synthesis, magnetic, thermal and structural properties of Co(II), Ni(II) and Cu(II) complexes containing isophthalato ligands
A series of novel ternary Co(II), Ni(II) and Cu(II) complexes containing 2,20-dipyridylamine (dipya), 2,20-bipyridine (bipy), and 1,10-phenanthroline (phen), as aromatic diamine ligands, and dianion of isophthalic acid (ipht) have been prepared by ligand exchange reactions from diluted H2O/EtOH solutions. The complexes were characterized by elemental analysis, IR spectroscopy, magnetic susceptibility measurements and TG and DSC analysis. Three complexes, Cu(dipya)(ipht)H2O (1), Co(dipya)(ipht)2H2O (2) and Cu(ipht)(phen)2H2O (5) are polymeric with bis-monodentate ipht, while the other two complexes M(bipy)(ipht)4H2O, M@Co(II) (3) and ...комплекси прелазних метала, карбоксилатни лиганди, N-лиганди, кристална структура, магнетна својстваJelena Rogan, Dejan Poleti, Ljiljana Karanović, Zvonko Jagličić. "Synthesis, magnetic, thermal and structural properties of Co(II), Ni(II) and Cu(II) complexes containing isophthalato ligands" in Journal of Molecular Structure, Elsevier BV (2011). https://doi.org/10.1016/j.molstruc.2010.11.024
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Crystallographic, spectroscopic, thermal and computational studies of polymeric cobalt(II)–mellitate complex with 2,2′-bipyridine
Orange single crystals of new polymeric cobalt(II) complex {[Co(bipy)(H2O)4]2[Co(μ-mell)(H2O)2]·10H2O}n, 1, were synthesized by slow evaporation method at room temperature (bipy = 2,2′-bipyridine, mell = hexaanion of mellitic acid) and its crystal structure was determined by single-crystal X-ray diffraction. The complex 1 was characterized based on elemental analysis, FTIR spectroscopy and thermal (TG/DTA) analysis followed by computational analysis of noncovalent interactions and quantum chemical calculations of interaction energies. In 1, two crystallographically different Co(II) atoms adopt a deformed octahedral geometry, ...Lidija Radovanović, Dušan P. Malenov, Marko V. Rodić, Aleksandar Kremenović, Jelena Rogan. "Crystallographic, spectroscopic, thermal and computational studies of polymeric cobalt(II)–mellitate complex with 2,2′-bipyridine" in Journal of Molecular Structure, Elsevier BV (2021). https://doi.org/10.1016/j.molstruc.2021.132202
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An update on the mineral-like Sr-containing transition metal arsenates
Tamara Đorđević, Ljiljana Karanović (2021)We report on the crystal structures of three novel synthetic SrM-arsenates (M = Ni and Fe3+), isostructural or structurally related to the minerals from tsumcorite, carminite and brackebuschite groups. They were synthesised under mild hydrothermal conditions and further characterised using single-crystal X-ray diffraction (SXRD), scanning electron microscopy with energy dispersive spectroscopy (SEMEDS) and Raman spectroscopy. SXRD and SEM-EDS yielded formulae: (I) SrNi2(AsO4)2·2H2O, (II) Sr1.4Fe3+ 1.6(AsO4)2(OH)1.6 and (III) SrFe3+(AsO4)(AsO3OH). All three structures are built up of slightly distorted MO6 octahedra ...арсенати метала, кристална структура, дифракција рендгенских зрака на монокристалима, хидротермална синтеза, Раманова спектроскопија, релевантна једињења у животној средини, арсенeochemistry and PetrologyTamara Đorđević, Ljiljana Karanović. "An update on the mineral-like Sr-containing transition metal arsenates" in Mineralogical Magazine, Mineralogical Society (2021). https://doi.org/10.1180/mgm.2021.41
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Water in the Alluaudite Type-Compounds: Synthesis, Crystal Structure and Magnetic Properties of Co3(AsO4)0.5+x(HAsO4)2−x(H2AsO4)0.5+x[(H,□)0.5(H2O,H3O)0.5]2x+
In this study, a new cobalt arsenate belonging to the alluaudite supergroup compounds with the general formula of Co3(AsO4)0.5+x(HAsO4)2−x(H2AsO4)0.5+x[(H, )0.5(H2O,H3O)0.5]2x+ (denoted as CoAsAllu) was synthesized under hydrothermal conditions. Its crystal structure was determined by a room-temperature single-crystal X-ray diffraction analysis: space group C2/c, a = 11.6978(8), b = 12.5713(7), c = 6.7705(5) Å, b = 113.255(5)◦, V = 914.76(11) Å3, Z = 2 for As6H8Co6O25. It represents a new member of alluaudite-like protonated arsenates and the first alluaudite-like phase ...супергрупа алуаудита, арсенати прелазних метала, хидротермална синтеза, кристална структура, хидратисани хидрокси-арсенати, стехиометрија, магнетна својстваTamara Đorđević, Ljiljana Karanović, Marko Jagodič, Zvonko Jagličić. "Water in the Alluaudite Type-Compounds: Synthesis, Crystal Structure and Magnetic Properties of Co3(AsO4)0.5+x(HAsO4)2−x(H2AsO4)0.5+x[(H,□)0.5(H2O,H3O)0.5]2x+" in Minerals, MDPI AG (2021). https://doi.org/10.3390/min11121372
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Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach
Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...... nitrogen flow during the measurements was set to 50 mL/min. X-ray Powder Diffraction Analysis (XRPD) Nanocrystal dispersions with different particle sizes, corresponding suspension, and unprocessed DK-I-60-3 were investigated by X-ray powder diffraction (XRPD). Dispersions were centrifuged, and the analysis ...
... parameters. The nanoparticles characterization included particle size and zeta potential measurements, differential scanning calorimetry, X-ray powder diffraction, dissolution and solubility study, and in vivo pharmacokinetic experiments. Developed formulations had small uniform particle sizes and ...
... included particle Accepted: 29 July 2021 Published: 31 July 2021 size and zeta potential measurements, differential scanning calorimetry, X-ray powder diffraction, dissolution and solubility study, and in vivo pharmacokinetic experiments. Developed formulations had small uniform particle sizes and were ...Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188