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Упит dcterms_creator_txt:Batalović K.

693 items

  • The Fuzzy–AHP Synthesis Model for Energy Security Assessment of the Serbian Natural Gas Sector

    Aleksandar R. Madžarević, Dejan D. Ivezić, Miloš L. Tanasijević, Marija A. Živković (2020)
    Natural gas is used for the production of almost 20% of total energy today. The natural gas security of the Republic of Serbia is an urgent strategic, political and security issue. Serbia is one of the most vulnerable countries in Southeast Europe, because it only has one supply route. This study is a contribution to efforts to better understand the factors affecting energy security through the implementation of a new methodology based on the fuzzy–AHP synthesis model for measuring ...
    energetska bezbednost, prirodni gas, fazi AHP, AHP višekriterijumska analiza, fazi teorija
    ... security assessment to a particular fuzzy set or linguistic variable—very low, low, moderate, high and exceptional [66]: di(Mi, LVi) = SQRT(ΣµM k − αLVi k) (18) for k= 1, . . . , 10, where LVi= {very low, low, moderate, high and exceptional} is defined with expression 1 and 2. Symmetry 2020, 12, 908 12 ...
    ... exceptional. Applying expression 18–20 to SC1 combined scenario produces the identification results shown in Table 36. di(ESSC1, “very low” = √ ∑10 k=1 µ k M − αk LVi = √ (0− 1)2 + (0.098− 1)2 + (0.278− 0)2 + (0.549− 0)2 + (0.549− 0)2 + (0.549− 0)2 + (0.428− 0)2 + (0− 0)2 + (0− 0)2 + (0− 0)2 = 1 ...
    ... import supply routes based on the natural gas capacities available for supply. The index is calculated as follows [57]: IDIRS = border x ∑ i ( TI ∑ k %TIkborder Xi) 2 + ∑ m (%LNG terminal)2 (37) where: Symmetry 2020, 12, 908 26 of 42 % TIk border X—percentage of technical capacity relative ...

  • Why classical sequence stratigraphy doesn't work in Pannonian basin?

    Dejan Radivojević (2018)
    basen iza ostrvskog luka, detačment, miocen, Panonski basen, riftogeneza, sekvenciona stratigrafija
    ... atigraphy, Earth‐Science Reviews, 92, 1–33.  Catuneanu, O., 2006. Principles of Sequence Stratigraphy. Elsevier, Amsterdam, 375 pp.  Emery, D., and K. J. Myers, 1996. Sequence Stratigraphy, Blackwell Science, p. 1–297.  Ivanišević,  S. and Radivojević, D., 2018. Upper Miocene depositional environme ...

  • Development of the Availability Concept by Using Fuzzy Theory with AHP Correction, a Case Study: Bulldozers in the Open-Pit Lignite Mine

    Stevan Đenadić, Dragan Ignjatović, Miloš Tanasijević, Uglješa Bugarić, Ivan Janković, Tomislav Šubaranović (2019)
    Availability is one of the most used terms in maintainability engineering. This concept is used to denote: The quality of service of an engineering system, i.e., machines, weak points’ analysis, asset management, as well as making decisions in the process of life cycle management. Availability is an overall indicator and contains partial indicators that are oriented towards reliability, maintenance, and logistical support. Availability presents a variable value and changes in time and space. Usually, availability is shown as the ...
    raspoloživost, fazi teorija, AHP višekriterijumska analiza, eksperska ocena, buldozer
    ... 60300, 2003–01. Available online: https://webstore.iec.ch/preview/info_iec60300-3-1%7Bed2.0%7Den.pdf (accessed on 16 October 2019). 6. Strandberg, K. IEC 300: The Dependability Counterpart of ISO 9000. In Proceedings of the Annual Reliability and Maintainability Symposium, Orlando, FL, USA, 29–31 ...
    ... assessment of agricultural machinery based on fuzzy sets theory. Expert Syst. Appl. 2012, 39, 8940–8946. [CrossRef] 11. Ebramhimipour, V.; Suzuki, K. A synergetic approach for assessing and improving equipment performance in offshore industry based on dependability. Reliab. Eng. Syst. Saf. 2006, 91 ...
    ... g Handbook; Introduction Chapter; McGraw-Hill Education: New York, NY, USA, 2007. 16. Erkoyuncu, J.A.; Khan, S.; Eiroa, A.L.; Butler, N.; Rushton, K.; Brocklebank, S. Perspectives on trading cost and availability for corrective maintenance at the equipment type level. Reliab. Eng. Syst. Saf. 2017 ...

  • A tool for identifying the criticality in the disordered systems with metastable dynamics

    Svetislav Mijatović, Dragutin Jovković, Sanja Janićević, Stefan Graovac, Đorđe Spasojević (2021)
    Физика кондензоване материје

  • Determining the Availability of Continuous Systems at Open Pits Applying Fuzzy Logic

    Miljan Gomilanović, Miloš Tanasijević, Saša Stepanović (2022)
    This work presents a model for determining the availability of continuous systems at open pits by applying fuzzy logic and fuzzy inference systems. The applied model was formed by the synthesis of independent partial indicators of availability. The model is based on an expert system for assessing the availability of continuous mining systems. The availability of the system, as a complex state parameter, is decomposed into the partial indicators, reliability, and convenience of maintenance, and the fuzzy compositions, used ...
    системи, континуални систем експоатације, површински коп, рударство, расположивост, фази логика, max–min композиција, min–max композиција

  • Analiza primenjenih metoda za transport parafinske nafte

    Dunja Milojević (2024)
    Sadržaj parafina u nafti ima dominantan uticaj na svojstva parafinskih nafti. Taloženje parafina, odnosno taloženje čvrstih čestica parafinskog voska, predstavlja ozbiljan globalni problem tokom proizvodnje i transporta sirove nafte. Samo taloženje voska zavisi od termodinamičkih faktora, poput temperature, pritiska i sastava nafte. Transport nafte cevovodima je uobičajeni proces transporta u naftnoj industriji. Kada prilikom cevovodnog transporta parafinske sirove nafte, dođe do prekida protoka i hlađenja nafte ispod temperature stinjavanja, parafini će kristalisati, pri čemu će doći do, geliranja celokupne transportovane ...
    nafta, parafinski vosak, taloženje, transport, naftovod
    ... 919-923. 8. Danilović, D., Karović Maričić, V., Batalović, V., Ivezić, D., & Živković, M. (2011). Analiza postojećih domaćih grejnih kablova i razvoj specifičnog za primenu u naftnoj industriji. Tehnika - Klektrotehnika, 60, str. 606-610. 9. Doeble, K. (2018). Wax Deposition as a Function of Flow ...
    ... MAPEFRE Global Risks. (2022). Oil and gas pipelines — veins of the economy. Risks Management and Insurance Magazine. 14.Misra, S., Baruah, S., & Singh, K. (1995). Paraffin Problems in Crude Oil Production And Transportation. SPE Production & Facilities, 10(1), 50-54. 15.Prstojević, B. (2012). Cevovodni ...
    ... y /IaraTanHH peno3HTOpHjyM yHece MOj 3aBPIHIHH PaJL IOI HaCJIOBOM: rArH Z/ernu/3/1___I1 DjA/ 4 E HiiyLX___AMAET O / _34-— TZA-HCnORO7 P7/EO LI K E {O T KOJH je MOJe ayTOPpCKO eJIO. 3aBpmuHH paji ca CBHM TNIpHJ1O3HMa Hpejao/Hna caM y eJIČKTDOHCKOM (bOpMaTy HIOTOJIHOM 32 TpajHo apxHBHpabe. ...

  • Одређивање резерви нафтног лежишта „Х“ методом материјал баланса

    Александра Петровић (2024)
    Метода материјалног баланса је кључна техника у процени резерви нафте и гаса у лежиштима која омогућава системско прорачунавање доступних резерви. Циљ ове методе је да се прецизно израчунају количине флуида у лежишту на основу доступних PVT података, података о лежишту и производњи. Резултати примене методе материјалног баланса показују да је она ефикасна у пружању кавнтитативних процена, међутим њена тачност зависи од квалитета улазних података. Метода материјалног баланса пружа основу за процену резерви, али може бити подложна грешкама због непрецизности ...
    материјални баланс, прорачун, енергетски режим, притисак, аквифер
    ... uckopurniheme Ha(THHx nexxumrTa Ca BOJIOHAIIODHHM pe)KHMOM CC Kpehe ojti 35% no 75%. ~ | | F3 7 Jlexwuiw npvracak 21 <—zZ— - = e 1I Sbai | i - K c ık o ı | 3 [ON ii O_ g 10 6 o F o [-] & | c || – || 20 8 | 9R ol ___ 1 | ı | | | | ___ ž Š 2j10311932 1033 1934 1035 1036 1937 1038 ...
    ... Cuuka 6.4. aanpeMunHcku (bakmop nadme y (pyakuuju npumucka — Glaso xopenauyuja Oil FVE 1,45) Temperature (deg C) 93,3333 1,4 F Fi | ' — K,S5 - |3 - || 8 |} i E/ % 120 150 180 210 Fressure (BARa) Opticns Summary il lack Oil iSingle-Stage ?VT Tnput Data Form. GOR: 0 (Sm3/Sm3) ...
    ... aKBH(DCDOM MOJICII ycarnanıcH ca HCTOpHJCKHM BPpeJIHOCTHM4. Ta0e:na 6.4. IIonanu o akBH(Depy r, [m] 2804,16 To/Ti 7,41084 Oeme, ["] 106,414 k, [md] 227 55 Mnalytical Method ur e (B AR a Cnuka 6.10. IIpumucak neuuwima y (byakuuju KyMyanamus6He npou36o0?be ca aKau(bepoM IpajbmMuka ...

  • Machine Learning and Deep Neural Network-Based Lemmatization and Morphosyntactic Tagging for Serbian

    Ranka Stanković, Branislava Šandrih, Cvetana Krstev, Miloš Utvić, Mihailo Škorić (2020)
    The training of new tagger models for Serbian is primarily motivated by the enhancement of the existing tagset with the grammatical category of a gender. The harmonization of resources that were manually annotated within different projects over a long period of time was an important task, enabled by the development of tools that support partial automation. The supporting tools take into account different taggers and tagsets. This paper focuses on TreeTagger and spaCy taggers, and the annotation schema alignment ...
    Part-of-Speech tagging, lemmatization, corpus, evaluation, Serbian, morphological dictionary
    ... resources and evaluation, 46(1):131–142. Gavrilidou, M., Labropoulou, P., Piperidis, S., Giouli, V., Calzolari, N., Monachini, M., Soria, C., and Choukri, K. (2006). Language resources production models: the case of the intera multilingual corpus and terminology. Politics, 39(39):78. Giménez, J. and Màrquez ...
    ... Natural Language Understanding with Bloom Embeddings, Con- volutional Neural Networks and Incremental Parsing. To appear. Huang, Z., Xu, W., and Yu, K. (2015). Bidirectional LSTM-CRF Models for Sequence Tagging. Krstev, C., Vitas, D., and Erjavec, T. (2004). Morpho- Syntactic Descriptions in MULT ...

  • Српски језик у дигиталном добу -- The Serbian Language in the Digital Age

    Duško Vitas, Ljubomir Popović, Cvetana Krstev, Ivan Obradović, Gordana Pavlović-Lažetić, Mladen Stanojević (2012)
    Serbian language
    ... проблеме. То отвара велике могућности за продуктивну сарадњу. 15 ћирилица А Б В Г Д Ђ Е Ж З И Ј К Л Љ М а б в г д ђ е ж з и ј к л љ м латиница A B V G D Đ E Ž Z I J K L Lj M a b v g d đ e ž z i j k l lj m ћирилица Н Њ О П Р С Т Ћ У Ф Х Ц Ч Џ Ш н њ о п р с т ћ у ф х ц ч џ ш латиница N Nj O P R ...
    ... proper way to write, and pronounce the name, is Шекспир and Šekspir). Cyrillic А Б В Г Д Ђ Е Ж З И Ј К Л Љ М а б в г д ђ е ж з и ј к л љ м Latin A B V G D Đ E Ž Z I J K L Lj M a b v g d đ e ž z i j k l lj m Cyrillic Н Њ О П Р С Т Ћ У Ф Х Ц Ч Џ Ш н њ о п р с т ћ у ф х ц ч џ ш Latin N Nj O P R S T Ć ...
    ... не постоји ни формализо- вана синтакса српског, што ограничава развој син- таксички и семантички анотираних корпуса. Форма- 34 К ва нт ит ет Д ос ту пн ос т К ва ли те т П ок ри ве но ст Зр ел ос т О др жи во ст П ри ла го дљ ив ос т Језичке технологије (алати, технологије, ...

  • Fuzzy Model for Risk Assessment of Machinery Failures

    Dejan V. Petrović, Miloš Tanasijević, Saša Stojadinović, Jelena Ivaz, Pavle Stojković (2020)
    The main goal of this research was the development of an algorithm for the implementation of negative risk parameters in a synthesis model for a risk level assessment for a specific machine used in the mining industry. Fuzzy sets and fuzzy logic theory, in combination with statistical methods, were applied to analyze the time picture state of the observed machine. Fuzzy logic is presented through fuzzy proposition and a fuzzy composition module. Using these tools, the symmetric position of the ...
    fazi teorija, rizik, otkaz rudarskih mašina
    ... risk level. The first stage of the risk assessment model is to determine the risk level of failure for the kth component in the technical system, where k = 1, 2, . . . , n. The level of risk of failure of one component of a mining machine is determined based on the risk indicator for the kth component ...
    ... Fuzzy probabilistic expert system for occupational hazard assessmentin construction. Saf. Sci. 2017, 93, 16–28. [CrossRef] 11. Mahdevari, S.; Shahriar, K.; Esfahanipour, A. Human health and safety risks management in underground coal mines using fuzzy TOPSIS. Sci. Total Environ. 2014, 488–489, 85–99. ...
    ... 2013, 26, 197–208. [CrossRef] Symmetry 2020, 12, 525 26 of 26 14. Chang, Y.; Wu, Y.; Chen, G.; Ye, J.; Chen, B.; Xu, L.; Zhou, J.; Yin, Z.; Ren, K. Comprehensive risk assessment of deepwater drilling riser using fuzzy Petri net model. Process Saf. Environ. 2018, 117, 483–497. [CrossRef] 15. Balaraju ...

  • Proračun recirkulacionih pumpi u postrojenju za odsumporavanje dimnih gasova ,,TENT B"

    Tomislav Trpković (2024)
    Predmet ovog rada baziraće se na proračunu i usvajanju mašinskih instalacija potrebnih za nesmetano funkcionisanje sistema dve međusobno povezane celine Absorber - Pumpna stanica, preko FRP ( Fiberglass Reinforced Plastic) cevovoda kojim se odvija transport suspenzije krečnjaka neophodnog u samom procesu odsumporavanja dimnih gasova. Pored tehničkog opisa same tehnologije koja uključuje tri objekta: Absorber, Pumpna Stanica i cevovod, glavni deo rada odnosiće se na proračun i usvajanje mašinskih instalacija koji uključuju recirkulacione radijalne centrifugalne pumpe i cevovode kojima ...
    postrojenje za odsumporavanje dimnih gasova, termoelektrana, pumpna stanica, FRP cevovod, Absorber, transport suspenzije gipsa, prirubnica, ventil, potisni cevovod, usisni cevovod
    ... kotlovi“ LJ. Brkić, T. Živanović, D. Tucaković, Univerzitet u Beogradu, Mašinski fakultet, 2010 . „Hidrauličke ı pneumatičke mašine“ Veselin Batalović, Univerzitet u Beogradu, Rudarsko geološki fakultet, 1996 . „ Mehanika fluida“ Cvetko Crnojević, Univerzitet u Beogradu, Mašinskifakultet, 2014 ...
    ... - 8 brezona Tabela 4.2 Kompenzatori Oznaka kompenzatora proizvođačaDitec Fl ui d Te mp er at ur a [P C] Na dp ri ti sa k [b ar ] Po dp ri ti sa k [b ar ] Ak si ja ln a ko mp re si ja [m m] Ak si ja ln o iz du že nj e [m m] Po pr eč no po me ra nj e [m m] ...
    ... kako bi se sprečilo habanje i hemijska korozija. ) SOO. 435 LewstungeDenarr av w InDUT _425. P Pulss abe. kv Pootenza 255 ermiogen Potercia e k ld 400 soo + + + + + o 2000 m 4000 ecoo OOO 10000 12000 14000 16000 DOO-CCTMUU Foroermenge”FloaOeD Por:ata/Capacitett'Caucaı 2 0_0 Oe:17 O7 ...

  • Numerical modeling of Selanac debris flow propagation using SPH code

    Jelka Krušić, Biljana Abolmasov, Miloš Marjanović, Manuel Pastor, Saeid M. Tayyebi (2021)
    The Selanac debris flow is a very huge event triggered after extreme rainfall caused by Cyclone Tamara activity in the Republic of Serbia in May 2014. The Selanac case study was already modelling in different programs using Voellmy rheology assumptions like RAMMS software. In this paper research are focusing particularly on the process of debris flowing from initiation zone to main deposition area using Geoflow SPH two-phase model considering frictional rheology law. Main rheological parameters are back-calculated using also ...
    debris flow, modelling, SPH code, DEM
    ... Geomorphology, 214: 502-513. Rickenmann, D. (1999) ‘’Empirical relationships for debris flows’’. Natural Hazards 19: 47-77. Savage, S.B., Hutter, K. (1989). ‘’The motion of a finite mass of granular material down a rough incline’’. Journal of Fluid Mechanics 199 (1): 177-215. Takahashi, T. (2007) ...

  • Failure Estimation of the Majdanpek Open Pit East Face Based on Inverse Velocity Model

    Miloš Marjanović, Stefan Milanović, Nikola Simić, Lazar Kričak (2024)
    The Majdanpek open pit mine south district is currently active mining prospect of copper ore exploitation in eastern Serbia. Its depth is approaching the termination depth and occurrences of large-scale instabilities and global instability of the final pit slope is possible. These can generate catastrophic mass movement inside an area that encloses a regional road route and the Pek River bed which is channelled along the outer contour of the pit. The displacements that were noted in early 2023, in the ...
    displacement, survey, inverse velocity, open pit

  • Analysis and visualization of geophysical well-logging data from closely spaced boreholes

    Branislav Sretković, Ivana Vasiljević, Dimitry Sidorov - Biryukov (2024)
    Geophysical logging measurements for determining the condition of the rock mass on the dam profile and locating the predisposed directions of water circulation and loss from the reservoir were conducted in four boreholes distributed at a close distance. The survey was carried out in a typical karst terrain, which is an additional challenge for defining the geological model, especially in terms of water retention. That kind of data set provides an excellent opportunity for a new approach to analysis ...
    well-logging in karst, water loss, data correlation, data fusion
    ... based on contract no. 451-03-65/2024-03/200126. 102 REFERENCES Hussain Y., Uagoda, R.; Borges, W.; Nunes, J.; Hamza, O.; Condori, C.; Aslam, K.; Dou, J.; Cardenas-Soto M, 2020: The Potential Use of Geophysical Methods to Identify Cavities, Sinkholes and Pathways for Water Infiltration ...

  • Geološko-geofizički model dela Timočkog magmatskog kompleksa

    Snežana M. Ignjatović (2014-06-30)
    Timočki magmatski kompleks (TMK) u geotektonskom smislu pripada KarpatoBalkanidimaistočne Srbije, koji su deo Tekijsko-Dakijske jedinice. TMK je nastaotokom kontinuirane vulkanske aktivnosti, koja je trajala oko deset miliona godina iodvijala se generalno u tri faze (Zimmerman et al., 2008, Kolb et al., 2013, Banješević,2006). Pomeranje vulkanskog fronta je išlo od istoka ka zapadu (von Quadt et al., 2002,2003, 2007). Ovaj kompleks pripada tetijskom evroazijskom metalogenetskom pojasu usvetu poznat po ležištima bakra i zlata (Janković, 1990).U doktorskoj disertaciji su prikazani rezultati ...
    Timočki magmatski kompleks, aeromagnetska istraživanja, gravimetrijskaistraživanja, 2D geološko-geofizički model, Valja Strž, magmatsko telo
    ... polymetallic deposit, Serbia: Mineral inclusions or true solid-solution? Canadian Mineralogist 46, 249–261. Pačevski, A., Moritz, R., Kouzmanov, K., Marquardt, K., Ţivković, P., Cvetković, LJ., 2012. Texture and composition of Pb-bearing pyrite from the Čoka Marin polymetallic deposit, Serbia, controlled ...
    ... i slojevitim sprudnim i subsprudnim krečnjacima i dolomitima. Geološko-geofizički model dela Timočkog magmatskog kompleksa 13 S li k a 2 . G eo lo šk a ka rta Geološko-geofizički model dela Timočkog magmatskog kompleksa 14 Kreda Na istraţnom području se izdvajaju ...
    ... Magistarska teza, Fond Rudarskogeološkog fakulteta, Univerziteta u Beogradu, Beograd, st. 89. Banješević, M. Cocić, S., Radović, M., 2001. Petrology and K/Ar ages of volcanic rocks for widen Bor zone as the part of the Timok Magmatic Complex (East Serbia). ABCD GEODE Workshop, Vata Bai, Romania, Abstract ...

  • Stratigraphy and microfossils (radiolarians and planktonic foraminifers) of the Upper Cretaceous (upper Santonian–lower Campanian) Struganik limestone (Western Serbia)

    Liubov G. Bragina, Nikita Yu. Bragin, Ludmila F. Kopayevich, Nevenka Đerić, Nataša Gerzina Spajić (2019)
    Paleontology, Stratigraphy, Ecology, Evolution, Behavior and Systematics

  • Definition of Circulation Conditions and Groundwater Genesis of the Complex Krupaja Hydrogeological Karst System (Eastern Serbia)

    Ljiljana Vasić, Saša Milanović, Tina Dašić (2023)
    Management, Monitoring, Policy and Law,Renewable Energy, Sustainability and the Environment, Geography, Planning and Development, Building and Construction
    ... period of flooding in 2014, when an amount of approximately 31 m3 /s drained out from the spring [12] (Figure 2). Entrance / [6} (220 m a.s.l.) {%K 0 50 De pt h (m ) ru pa js ko sp ri ng n = — |100 sa nd st on e Re d pe rm ia l _423.m _ EXplored channels by cave divers ...
    ... spring, i.e., 211.57 mg/L (Table 6). Table 6. Results of ionic composition tests of groundwater from the Krupaja system. . mg/L Location Caž*+ K+ Mgž*+ Nat F- CI- NO_ SO22- HCO,- Krupaja Spring—Winter 34.92 1.15 1.553 1.899 0.018 2.2289 5.2377 12.5445 106.3433 Krupaja Spring—Spring, 35.29 0 ...

  • Numeričko modelovanje povećanja iskorišćenja naftnih ležišta injektiranjem polimera i analiza osetljivosti parametara

    Jana Šujica (2024)
    U toku proizvodnje jednog ležišta, nakon primene sekundarnih metoda iskorišćenja, velika količina nafte ostaje zarobljena u ležištu. Ovaj “problem” rešava se upotrebom tercijarnih metoda iskorišćenja.Tercijarne metode mogu se podeliti na: hemijske, termičke, mikrobiološke i metode utiskivanja gasova u uslovima mešanja i nemešanja.U ovom radu analiziraju se hemijske metode koje se odnose na injektiranje polimera u cilju povećanja iskorišćenja naftnog ležišta “X”. Simulacija je rađena u simulatoru “Tnavigator” na sintetičkom modelu u cilju definisanja stepena iskorišćenja naftnog ležišta “X” nakon ...
    povećanje iskorišćenja, utiskivanje polimera, numerička simulacija
    ... Na slici 1.1.3. prikazane su krive frakcionog protoka u funkciji zasićenja vodom pri različitim uslovima mobiliteta. FR AK CI ON I P R O T O K ZASIČENJE VODOM, % Figure 1.1.3. Krive frakcionog protoka [6] Viskozitet vode predstavlja Jjedan od najvažnijih parametara za definisanje ponašanja ...
    ... [9] SW — SWCR S„ . =S„ (S,) = —A|H fq Ć_R __— (3.3.3.1) n W W 1 — SWCR — SOWCR — SGL SwcR — Sw kronw + (kyoLw-kronw) OBE .BN Sw, < Sw < SwcR k Sw„) = WCR WL 3.3.3.2 roRw(Sy) kronw(1 — Syyn)noV, Swcn < Sw < 1 — Sowcn — Sa, ( ) 0, 1 — Sowcn — SaL < Sw < Swu 29 0, Sw, < Sw < SwcR _ krwn(Swn)"" ...

  • Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study

    Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)
    Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...
    Pharmaceutical Science
    ... Lyophilization was performed under two «conditions. For lyophilization-1, samples were frozen at -80 "C for 3 h and then freeze- dried in a Beta 1–8 K freeze dryer (Martin Christ, Osterode am Harz, Germany) for 24 h, with primary drying at -10 "C and 0.340 mbar and secondary drying at 25 "C. Samples ...
    ... les: formulation, process and storage considerations. Adv. Drug Deliv. Rev. 58 (15), 1688–1713. https://doi.org/10.1016/j.addr.2006.09.017. Akao, K.1., Okubo, Y., Asakawa, N., Inoue, Y., Sakurai, M., 2001. Infrared spectroscopic study on the properties of the anhydrous form II of trehalose. Implications ...
    ... Ind. Pharm. 44 (9), 1458–1466. https://doi.org/10.1080/03639045.2018.1460377. Holzer, M., Vogel, V., Mšntele, W., Schwartz, D., Haase, W., Langer, K., 2009. Physico- chemical characterisation of PLGA nanoparticles after freeze-drying and storage. Eur. J. Pharm. Biopharm. 72 (2), 428-437. https://doi ...

  • Characterization of the eastern Suva Planina Mt. karst aquifer (SE Serbia) by time series analysis and stochastic modelling

    Branislav Petrović, Veljko Marinović, Zoran Stevanović (2023)
    Earth-Surface Processes,Geology, Pollution, Soil Science, Water Science and Technology, Environmental Chemistry, Global and Planetary Change