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Упит dcterms_creator_txt:Mitrović Stojan

63 items

  • Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach

    Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)
    Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...
    pyrazoloquinolinones, nanocrystals, wet media milling, fasted/fed bioavailability
    ... Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić ...
    ... Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach | Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić ...

  • Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study

    Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)
    Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...
    Pharmaceutical Science
    ... of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, ...
    ... of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study | Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique ...
    ... novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study Jelena R. Mitrović*, Maja Bjelošević Žiberna b, Aleksandar Vukadinović", Daniel E. Knutson d, Dishary Sharmin d, Aleksandar Kremenović *, Pegi Ahlin Grabnar , Odon ...

  • Споменица 1991. – 2015. година: 135 година геологије и 70 година рударства на Универзитету у Београду

    главни и одговорни уредник Душан Поломчић (2016)
    Рударско-геолошки факултет
    ... карбонати у Pb - Zn лежиштима Стари трг, Бело Брдо и Кижевак Геологија В. Похарц-Логар В. Похарц-Логар; Р. Димитријевић; Н. Костић 134. Митровић Стојан 18.11.2005. Модел управљања дејством експлозије у циљу добијања захтевне фрагментације минираног производа Рударство Н. Пуртић; ...
    ... ALMAŽAN V., STUPAR J., MITROVIĆ V., 2001: Uputstvo i radna sveska za labo- ratorijska merenja, tehnologiju nafte i njenih derivata, Beograd. MITROVIĆ V., 2002: Metode dinamičkih ispitivanja ležišta nafte i gasa. Udžbenik sa recenzijom u pripremi za štampu, Beograd. MITROVIĆ V., HRKOVIĆ K., 2005: ...
    ... u Zemlju. Др ЈОВАНКА МИТРОВИЋ-ПЕТРОВИЋ, редовни професор АНЂЕЛКОВИЋ М., ЕРЕМИЈА М., ПАВЛОВИЋ М., АНЂЕЛКОВИЋ Ј., МИТРОВИЋ- ПЕТРОВИЋ Ј., 1991: Палеогеографија Србије – терцијар. Завод за рег. геол. и палеонт. Руд.-геол. факулт., Београд, 237. АНЂЕЛКОВИЋ М., МИТРОВИЋ-ПЕТРОВИЋ Ј., 1991: Пале ...