Претрага
1149 items
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The Importance of Geotechnical Investigations for the Construction of Transfer Station „Prelići“ on Landfill in Cacak – Serbia
For the purpose of the facilities construction within the transfer station „Prelici“ in Cacak, specific geotechnical investigations were carried out based on which the technological project with the facilities schedule was developed. Significant deviations in relation to the presented results were determined during earthworks, so the additional geotechnical investigation works were carried out. Since the new investigation works have determined a different cross section of the terrain, it was proposed to move the planned facilities which led to the ...... hazardous wastes, Association for water technology and sanitary engineering, Niska Banja, 294-298. Rakic, D. (2013). Constitutive relations of landfill municipal waste in Serbia (in Serbian), Ph.D. thesis, University of Belgrade, Faculty of Mininag and Geology, Department of Geotechnics,Belgrade, pp ...
... self-government, the way of waste treatment is being improved, a certain number of workers of lower social status are employed and a positive economic effect is achieved. From a citizen's perspective, the introduction of a quality organization into the waste management system, with the exception ...
... rivers or in their vicinity (Rakic, 2013). Until 1994 at the city landfill „Prelici“, waste was disposed completely uncontrolled both in terms of technology and in terms of waste origin. This uncontrolled disposal led to the fact that landfill was closed in a longer period of 1994. Transfer station ...Dragoslav Rakić, Irena Basarić, Jovana Janković, Tina Đurić. "The Importance of Geotechnical Investigations for the Construction of Transfer Station „Prelići“ on Landfill in Cacak – Serbia" in 17th International waste management and landfill symposium, Proceedings SARDINIA 2019, CISA Publisher (2019)
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Novi model za postizanje optimalne proizvodnje na naftnom polju Amal
Elnori Elmabrouk Ali Elhaddad (2015-04-16)Doktorskom disertacijom analizirani su i proučavani problemi proizvodnje nafte iprimenjene metode za njihovo rešavanje na naftnom polju Amal. Ukratko jeprikazana proizvodnje nafte u Libiji, njene karakteristike i rezerve, da bi se videoznačaj ovog naftnog polja.Utvrđeno je da su na naftnom polju Amal ključni problemi koji prate procesproizvodnje taloženje parafina, pojava slojnog peska, neefikasan rad gasliftsistema, neefikasna desalinizacija nafte i ekološki problemi. Proizvodniproblemi, pojedinačno i više njih zajedno, na nekim bušotinama uzrokovali susmanjenje proizvodnje nafte od 40 do 75%. Zbog ...... optimization using an integrated asset model,” in SPE International Petroleum Technology Conference (IPTC '07), pp. 1371–1380, Dubai, UAE. Hallet D. (2002) History of Libyan oil exploration and production, Petroleum Geology of Libya, 17-47. Hallibarton, (2012), Filter construction. Hallibarton, ...
... crystals in waxy crude oils cooled in quiescent conditions and under flow, Fuel 82, 127–135. Kasumu A.S., Arumugam S., Mehrotra A.K. (2013 ) Effect of cooling rate on the wax precipitation temperature of ‘‘waxy’’ mixtures, Fuel, 103, 1144–1147. 91 King G.E., Wildt P.J., O'Connell E. (2003) Sand ...
... Harouge (2011), About Harouge Oil Operations, Harouge Oil Operations, www.vebalibya.com. Harvie C. (2013) Oil and economic development: Libya in the post-Gaddafi era, Economic Modelling, Volume 32, 273-285. Hatcher W.B., Chilingarian G.V., Solum J.R. (1989) Chapter 6 Gravel Packing, Developments ...Elnori Elmabrouk Ali Elhaddad. "Novi model za postizanje optimalne proizvodnje na naftnom polju Amal" in Универзитет у Београду, Универзитет у Београду, Рударско-геолошки факултет (2015-04-16)
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Novi model za postizanje optimalne proizvodnje na naftnom polju Amal
Elnori Elmabrouk Ali Elhaddad (2015-04-16)Doktorskom disertacijom analizirani su i proučavani problemi proizvodnje nafte iprimenjene metode za njihovo rešavanje na naftnom polju Amal. Ukratko jeprikazana proizvodnje nafte u Libiji, njene karakteristike i rezerve, da bi se videoznačaj ovog naftnog polja.Utvrđeno je da su na naftnom polju Amal ključni problemi koji prate procesproizvodnje taloženje parafina, pojava slojnog peska, neefikasan rad gasliftsistema, neefikasna desalinizacija nafte i ekološki problemi. Proizvodniproblemi, pojedinačno i više njih zajedno, na nekim bušotinama uzrokovali susmanjenje proizvodnje nafte od 40 do 75%. Zbog ...... optimization using an integrated asset model,” in SPE International Petroleum Technology Conference (IPTC '07), pp. 1371–1380, Dubai, UAE. Hallet D. (2002) History of Libyan oil exploration and production, Petroleum Geology of Libya, 17-47. Hallibarton, (2012), Filter construction. Hallibarton, ...
... crystals in waxy crude oils cooled in quiescent conditions and under flow, Fuel 82, 127–135. Kasumu A.S., Arumugam S., Mehrotra A.K. (2013 ) Effect of cooling rate on the wax precipitation temperature of ‘‘waxy’’ mixtures, Fuel, 103, 1144–1147. 91 King G.E., Wildt P.J., O'Connell E. (2003) Sand ...
... Harouge (2011), About Harouge Oil Operations, Harouge Oil Operations, www.vebalibya.com. Harvie C. (2013) Oil and economic development: Libya in the post-Gaddafi era, Economic Modelling, Volume 32, 273-285. Hatcher W.B., Chilingarian G.V., Solum J.R. (1989) Chapter 6 Gravel Packing, Developments ...Elnori Elmabrouk Ali Elhaddad. "Novi model za postizanje optimalne proizvodnje na naftnom polju Amal" in Универзитет у Београду, Универзитет у Београду, Рударско-геолошки факултет (2015-04-16)
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The different approaches in seismic stratigraphy interpretation
Dejan Radivojević (2018)U tekstu su prikazana dva osnovna pristupa u seizmostratigrafskoj interpretaciji. Prvi kao polaznu osnovu ima seizmičke sekcije, čija se interpretacija u kasnijoj fazi koreliše sa bušotinskim podacima. Drugi u prvoj fazi analizira podatke dobijene dubokim bušenjem koji se kasnije korelišu sa seizmičkim sekcijama. Prikazan je hronološki redosled i objašnjen postupak pri seizmostratigrafskoj interpretaciji oba pristupa. Ovakav način interpretacije omogućio je naftnim kompanijama detaljnije i preciznije sagledavanje geoloških odnosa, smanjenje rizika istraživanja i racionalnije projektovanje razradnih bušotina.seizmostratigrafija, istraživanje nafte i gasa, karakteristične seizmičke sekvence, seiz-mofacijalna analiza... Zagreb, 2005. [8] Ramasayer G. R, Seismic Stratigraphy; a fundame- ntal exploration tool. Offshore Technology Confere- nce, April-May 1979, Proceedings, 3, 1859-1867, Houston, Texas, 1979. [9] Sangree, J. B. & Widmer, J. M, Seismic Stratigraphy and global changes in sea level Part 9: seismic ...
... LITERATURA [1] Catuneanu O, Principles of Sequence Stratigraphy, Elsevier, pp 375, Amsterdam, 2007. [2] Emery D. & Myers K. J, Sequence Stratigraphy, Bla- ckwell Science, pp 297, Oxford, 2001. [3] Mitchum R. M. Jr. & Vail P. R, Seismic stratigraphy nad global changes of sea level, part 7: stratigraphic ...
... Tulsa, Oklahoma, 1977. [5] Piggot, D. J, Introduction To A Seismic Stratigraphy and Advanced Seismic Stratigraphy, OGCI Petro- skills, p 454, Tulsa, Oklahoma, 2008. [6] Pigott D. J. & Radivojević D, Seismic stratigraphy based chronostratigraphy (SBBC) of the Serbian Banat region of the ...Dejan Radivojević. "The different approaches in seismic stratigraphy interpretation" in Tehnika – rudarstvo, geologija i metalurgija, Savez inženjera i tehničara Srbije, Beograd (2018). https://doi.org/10.5937/tehnika1802211R
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Cutting Resistance Laboratory Testing Methodology for Underwater Coal Mining
... Coal is mined from the bottom of the lake connected to the Danube, and is the only mine with underwater coal exploitation in the world. A continuous technology performs the exploitation of overburden, gravel, and coal in this deposit. In accordance, mining of overburden and gravel is performed by using a ...
... Hemanta, H. Soil Mechanics Fundamentals and Applications; CRC Press: Boca Raton, FL, USA, 2015. 28. Verruijt, A. Soil Mechanics; Delft University of Technology: Delft, The Netherlands, 2010. 29. Terzaghi, K.; Peck, R.B.; Mesri, G. Soil Mechanics in Engineering Practice; John Wiley & Sons, Inc.: Hoboken, ...
... приступу. - Претрага репозиторијума доступна је на www.dr.rgf.bg.ac.rs The Digital repository of The University of Belgrade Faculty of Mining and Geology archives faculty publications available in open access, as well as the employees' publications. - The Repository is available at: www.dr.rgf.bg.ac ...Vladimir Čebašek, Veljko Rupar, Stevan Đenadić, Filip Miletić. "Cutting Resistance Laboratory Testing Methodology for Underwater Coal Mining" in Minerals, MDPI AG (2021). https://doi.org/10.3390/min11060564
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Geochemical evaluation of dolostone deposits in Montenegro: Implications for potential industrial applications
Darko Bozovic, Vladimir Simic, Dragan Radulovic, Slobodan Radusinovic, Vesna Matovic, Anja Terzic (2024)This study presents a unique model for assessing the dependability of continuous parts of combined systems in open-pit mining through the application of fuzzy logic. Continuous sub-systems as part of the combined system of coal exploitation in surface mines have the basic function of ensuring safe operation, high capacity with high reliability, and low costs. These subsystems are usually part of the thermal power plant’s coal supply system and ensure stable fuel supply. The model integrates various independent partial ...примарне сировине, минералогија, физичко-механичка својства, технолошка својства, наука о материјалимаDarko Bozovic, Vladimir Simic, Dragan Radulovic, Slobodan Radusinovic, Vesna Matovic, Anja Terzic. "Geochemical evaluation of dolostone deposits in Montenegro: Implications for potential industrial applications" in Science of Sintering, Bor, August 2024, National Library of Serbia (2024). https://doi.org/10.2298/SOS240701029B
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A Mathematical Learning Environment Based on Serbian Language Resources
In recent years, in line with ever growing usage of Information technology, the learning environments are changing. The amount of available learning materials in various forms has increased. These new environments demand comprehensive learning systems, which enable management of the learning corpus with special attention paid to relevant lexical resources. In this paper we present the concept of a Mathematical Learning Environment in Serbian (MLES), which is based on a corpus of mathematical materials and various lexical resources, enabling ...... University of Belgrade/Faculty of Mining and Geology, Belgrade, Serbia 3 University of Belgrade/Faculty of Philology, Belgrade, Serbia * marija.radojicic@uns.ac.rs Abstract: In recent years, in line with ever growing usage of Information technology, the learning environments are changing. The ...
... INTRODUCTION Rapid development of information technology, resulting in a growing number and availability of learning materials, had a strong impact on changes in learning environments. New learning environments are needed, requiring appropriate technology to facilitate access to and management ...
... resources, morphological e-dictionaries and WordNet of Serbian, which have been developed within the University of Belgrade Human Language Technology group for several decades [1], as well as a newly developed glossary, Termi. The system is aimed at providing for enrichment of these resources ...Radojičić Marija, Obradović Ivan, Stanković Ranka, Utvić Miloć, Kaplar Sebastijan. "A Mathematical Learning Environment Based on Serbian Language Resources" in Proceedings of the 7th International Scientific Conference Technics and Informatics in Education, Faculty of Technical Sciences, Čačak (2018)
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Numerical Models of Debris Flows with Entrainment Analysis-Case Studies from the Republic of Serbia
The results of material entrainment analysis in RAMMS debris flow software, as well as numerical models of final flow heights for two case studies from the Republic of Serbia are presented. Both of debris flow cases started with initial sliding of huge volume block, prolonging to behave as flowing process. Results of the analysis showed that entrainment material affects final results of transportation model, runout distance, deposition area and volume of debris flow. In both cases entrainment volume is very ...Jelka Krušić , Biljana Abolmasov, Miloš Marjanović. "Numerical Models of Debris Flows with Entrainment Analysis-Case Studies from the Republic of Serbia" in Understanding and Reducing Landslide Disaster Risk. WLF 2020. ICL Contribution to Landslide Disaster Risk Reduction, Springer, Cham (2021). https://doi.org/10.1007/978-3-030-60706-7_25
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The Usage of Various Lexical Resources and Tools to Improve the Performance of Web Search Engines
In this paper we present how resources and tools developed within the Human Language Technology Group at the University of Belgrade can be used for tuning queries before submitting them to a web search engine. We argue that the selection of words chosen for a query, which are of paramount importance for the quality of results obtained by the query, can be substantially improved by using various lexical resources, such as morphological dictionaries and wordnets. These dictionaries enable semantic ...LR web services, MultiWord Expressions & Collocations, Information Extraction, Information Retrieval... Proper Names. In Proc. of Second Language & Technology Conference, Poznań, Poland, April 21-23, Wydawnictwo Poznańskie Sp. z o.o, Poznań Tufiş, D. (ed.), (2004).: Special Issue on BalkaNet Project, Romanian Journal on Information Science and Technology. Bucureşti: Publishing house of the Romanian ...
... required by the preposition na. 7. In order to test our system we have used a log file of one of Serbian professional journals that deals with economic issues. The journal’s web site is supported by a search engine that enables its readers to retrieve information from journal’s archive. The used ...
... we have produced some new inflectional transducers as for the structure adjective+conjunction+adjective+noun in ekonomska i monetarna unija ‘economic and monetary union’ 8. The bilingual search – for instance, to the keyword štrajk and its Serbian synonym obustava rada a corresponding English ...Krstev Cvetana, Stanković Ranka, Vitas Duško, Obradović Ivan. "The Usage of Various Lexical Resources and Tools to Improve the Performance of Web Search Engines" in LREC 2008: Conference on Language Resources and Evaluation, Marrakesh, Morocco, May 2008, European Language Resources Association (ELRA) (2008)
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A hundred years of Milutin Milanković's climate change theory - geological implications
Dejan Radivojević (2020)Миланковићева теорија циклуса објављена пре сто година је најважнија теорија у наукама које проучавају климу и имала је велики утицај на дисциплине које се баве Земљом. Ипак, његов рад је чекао више од педесет година да би добио потврду. Може се рећи да Миланковићев рад највећи утицај на геологију има у изради астрономске временске скале, подршци хипотези континенталног дрифта и палеоклиматологији. Добри резултати примене астрономске временске скале на неогене седименте иницирали су примену ове методе у мезозојским и у последње ...циклостратиграфија, астономска временска скала, геолошка временска скала, климатске промене, континентални дрифт... “Mathematical Theory of Heat Phe- nomena Produced by Solar Radiation” was pub- lished hundred years ago. His theory affected geology and its different branches like stratigraphy, palaeoclimatology, tectonics etc. Recently a lot of scientific studies are focused on Astronomic Time Scale calibration for ...
... continental drift hypothesis and palaeo- climatology implications. Positive results of the implementation of the astronomic time scale to the Neo- gene stratigraphy initiated the application of this method within the Mesozoic, and lately also to the Paleozoic sediments. Milanković’s manuscript of astro- nomical ...
... on the GTS 2012 (GRADSTEIN et al., 2012) most of the Cenozoic era was directly calibrated with the ATS (Fig. 4). The International Commission on Stratigraphy encouraged with good results of Neogene ATS decided to complete a continuous ATS for the past 250 Ma, espe- cially because continuous ATS can restore ...Dejan Radivojević. "A hundred years of Milutin Milanković's climate change theory - geological implications" in Geološki anali Balkanskoga Poluostrva, Univerzitet u Beogradu, Rudarsko geološki fakultet (2020). https://doi.org/10.2298/GABP201125011R
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Hydrochemical changes and groundwater grouping data by multivariate statistical methods within one karst system: recharge–discharge zone (Eastern Serbia case study)
Ljiljana Vasić, Dragana Živojinović, Vladana Rajaković-Ognjanović. "Hydrochemical changes and groundwater grouping data by multivariate statistical methods within one karst system: recharge–discharge zone (Eastern Serbia case study)" in Carbonates and Evaporites, Springer Science and Business Media LLC (2020). https://doi.org/10.1007/s13146-019-00548-6
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Indexing of textual databases based on lexical resources: A case study for Serbian
In this paper we describe an approach to improvement of information retrieval results for large textual databases by pre-indexing documents using bag-of-words and Named Entity Recognition. The approach was applied on a database of geological projects financed by the Republic of Serbia in the last half century. Each document within this database is described by metadata, consisting of several fields such as title, domain, keywords, abstract, geographical location and the like. A bag of words was produced from these ...... and decision-making in the field of geology. Within the project a web portal3 was established that allows quick and easy access to geological data and information in the field of general geology, ex- ploration of mineral deposits, hydrogeology and engineering geology. Users of published information, ...
... they were inefficiently used be- cause of inadequate organization, limited access and general lack of readiness for the use of modern information technology. Consequently, the Ministry of Natural Resources and Environment Protec- tion, now the Ministry of Mining and Energy of the Republic of Serbia, ...
... H.: Introduction to Information Retrieval, vol. 1. Cambridge University Press (2008) 9. Martinović, M.: Transfer of Natural Language Processing Technology: Experi- ments, Possibilities and Limitations Case Study: English to Serbian. INFOtheca 9(1–2), 11a–21a (May 2008) 10. Maurel, D., Friburger, N ...Ranka Stanković, Cvetana Krstev, Ivan Obradović, Olivera Kitanović. "Indexing of textual databases based on lexical resources: A case study for Serbian" in Semantic Keyword-based Search on Structured Data Sources : First COST Action IC1302 International KEYSTONE Conference, IKC 2015, Coimbra, Portugal, September 8-9, 2015. Revised Selected Papers, Springer (2015). https://doi.org/10.1007/978-3-319-27932-9_15
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An aproach to Implementation of blended learning in a university setting
... Belgrade, Faculty of Mining and Geology, {ivano;ranka;olja;jelena.prodanovic;veselin.ilic}@rgf.bg.ac.rs Abstract: In this paper we present an approach to introducing modern computer-mediated activities in course instruction at the Faculty of Mining and Geology - University of Belgrade, as a c ...
... encountered. This concept encompasses all aspects and processes of education that use WWW as a communication medium as well as its supporting technology [1]. Within the interaction of ICT and education many other terms, such as online education, virtual education, Internet-based education, and ...
... Journal of informatics and librarianship, Vol. XI, No.2, pp.3-19, 2010. [4] Teresa Martin-Blas, E-learning Platforms in Physics Education, in: Technology Education and Development, Aleksandar Lazinica and Carlos Calafate (eds.), InTech, pp.107-121, 2009. [5] Devedžić V., Semantic Web and Education ...Ivan Obradović, Ranka Stanković, Olivera Kitanović, Jelena Prodanović . "An aproach to Implementation of blended learning in a university setting" in Proceedings of the Second International Conference on e-Learning, eLearning 2011, September 2011, Belgrade, Serbia, Belgrade : Belgrade Metropolitan University (2011)
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A Fuzzy Expert Model for Availability Evaluation
Each technical system within itself carries the great potential danger of possible occurrence of failure and damages. Mining machines are characteristic by great investment values, costs of unplanned shutdowns, complex working conditions, and environment and workers hazards. Systematic monitoring of the mining machinery is of great importance for the management of the mining companies. Availability is the overall concept of quality of service. Includes information regard to operating state, an idle state, a standby state and shut down. The ...... reliability, maintainability, supportability and the other constituent parts of availability are crucial and must be established and optimized for the economic success of selected machine or overall business systems [5]. The most usual consideration of the availability of machines or any other engineering ...
... Fuzzy Expert Model for Availability Evaluation Dejan Ivezic Faculty of Mining and Geology University of Belgrade Belgrade, Serbia dejan.ivezic@rgf.bg.ac.rs Milos Tanasijevic Faculty of Mining and Geology University of Belgrade Belgrade, Serbia milos.tanasijevic@rgf.bg.ac.rs Radisa ...
... приступу. - Претрага репозиторијума доступна је на www.dr.rgf.bg.ac.rs The Digital repository of The University of Belgrade Faculty of Mining and Geology archives faculty publications available in open access, as well as the employees' publications. - The Repository is available at: www.dr.rgf.bg.ac ...Dejan Ivezić, Miloš Tanasijević, Predrag Jovančić, Radiša Đurić. "A Fuzzy Expert Model for Availability Evaluation" in Proceedings of the 2019 20th International Carpathian Control Conference (ICCC), AGH University of Science and Technology, Kraków - Wieliczka, Poland (2019)
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Definition of criteria and alternatives for choosing the optimal mining method deposits when applying multi: Criteria optimization, Belgrade, June 2024
Sanja Bajić, Dragoljub Bajić, Branko Gluščević, Radmila Gaćina, Josip Išek. "Definition of criteria and alternatives for choosing the optimal mining method deposits when applying multi: Criteria optimization, Belgrade, June 2024" in Podzemni radovi, Beograd, jun 2024, Centre for Evaluation in Education and Science (CEON/CEES) (2024). https://doi.org/10.5937/podrad2444071B
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Hydrogeochemistry of Uranium in the Groundwaters of Serbia
Marina Ćuk, Maja Todorović, Petar Papić, Jovan Kovačević, Zoran Nikić. "Hydrogeochemistry of Uranium in the Groundwaters of Serbia" in Uranium - Past and Future Challenges, Springer International Publishing Switzerland (2015). https://doi.org/10.1007/978-3-319-11059-2_89
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Effectiveness Analysis of Different Bucket-wheel Excavators
Coal production in open-pit lignite mines in the Republic of Serbia is performed with continuous work systems. In addition to coal production, the same systems are used for the exploitation of large quantities of overburden. According to the reliability concept, continuous systems are in linear connection. If the failure occurs in one part of the system, that will produce a downtime of the entire system. The initial and most important factor of continuous systems is the bucket-wheel excavator. It ...Stevan Đenadić, Predrag Jovančić, Dragan Ignjatović, Miloš Tanasijević, Filip Miletić. "Effectiveness Analysis of Different Bucket-wheel Excavators" in 8th International Conference Mining and Environmental Protection, Sokobanja, 22-25 September 2021, University of Belgrade, Faculty of Mining and Geology, Belgrade, Serbia (2021)
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Increasing the Local Road Network Resilience from Natural Hazards in Municipalities in Serbia
Biljana Abolmasov, Miloš Marjanović, Ranka Stanković, Uroš Đurić, Nikola Vulović. "Increasing the Local Road Network Resilience from Natural Hazards in Municipalities in Serbia" in Progress in Landslide Research and Technology, Volume 3, Issue 1, Springer Cham. (2024). https://doi.org/https://doi.org/10.1007/978-3-031-55120-8_22
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Improving Document Retrieval in Large Domain Specific Textual Databases Using Lexical Resources
Large collections of textual documents represent an example of big data that requires the solution of three basic problems: the representation of documents, the representation of information needs and the matching of the two representations. This paper outlines the introduction of document indexing as a possible solution to document representation. Documents within a large textual database developed for geological projects in the Republic of Serbia for many years were indexed using methods developed within digital humanities: bag-of-words and named ...... Suffix Division Faculty of Mining and Geology Organization University of Belgrade Address Belgrade, Serbia Email ivan.obradovic@rgf.bg.ac.rs Author Family Name Kitanović Particle Given Name Olivera Prefix Suffix Division Faculty of Mining and Geology Organization University of Belgrade Address ...
... primarily to establish an object- oriented database for digital archiving of geologic data in the field of general geology, exploration of mineral deposits, hydrogeology and engineering geology, as a modern and efficient information basis for planning, design and decision- making in the geological domain ...
... to the standard information retrieval performance measures, where the InQuery method performed the best. 1 Introduction Advancements in database technology provide nowadays for management of large quantities of heterogeneous data. However, besides this engineering challenge— efficient management of such ...Ranka Stanković, Cvetana Krstev, Ivan Obradović, Olivera Kitanović. "Improving Document Retrieval in Large Domain Specific Textual Databases Using Lexical Resources" in Trans. Computational Collective Intelligence - Lecture Notes in Computer Science 26, Springer (2017). https://doi.org/10.1007/978-3-319-59268-8_8
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Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach
Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...... grant agreements no. 451-03-9/2021-14/200161 (Faculty of Pharmacy), 451-03-09/2021-14/200126 (Faculty of Mining and Geology), and 451-03-9/2021- 14/200026 (Institute of Chemistry, Technology and Metallurgy); National Institutes of Health, USA through grants R01 NS076517 and R01 MH096463 and National Science ...
... conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). 1 Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia; jelena.mitrovic@pharmacy.bg.ac.rs (J.R ...
... Vojvode Stepe 450, 11221 Belgrade, Serbia; vladimir.dobricic@pharmacy.bg.ac.rs 6 Department of Microelectronic Technologies, Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Njegoševa 12, 11000 Belgrade, Serbia; danijela@nanosys.ihtm.bg.ac.rs * Correspondence: snezana.savic@pharmacy ...Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188