420 items

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  Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach cite

  Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)

  Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...

  pyrazoloquinolinones, nanocrystals, wet media milling, fasted/fed bioavailability

  Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188 М21

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  Prognoza operativne efikasnosti aktivnog podzemnog rudnika zasnovana na teoriji sivih sistema cite

  Svetlana M. ŠTRBAC-Savić (2016)

  podzemni rudnik, operativna efikasnost, teorija sivih sistema, simulacija

  Svetlana M. ŠTRBAC-Savić. Prognoza operativne efikasnosti aktivnog podzemnog rudnika zasnovana na teoriji sivih sistema, Beograd:Rudarsko Geološki Fakultet, 2016

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  Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study cite

  Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)

  Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...

  Pharmaceutical Science

  Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study" in European Journal of Pharmaceutical Sciences, Elsevier BV (2023). https://doi.org/10.1016/j.ejps.2023.106557 М21

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  Application of novel Zn-ferrite modified glassy carbon paste electrode as a sensor for determination of Cd(II) in waste water cite

  Stanković Dalibor M, Skrivanj Sandra, Savić Nenad, Nikolić Aleksandar, Vulić Predrag, Manojlović Dragan (2014)

  Stanković Dalibor M, Skrivanj Sandra, Savić Nenad, Nikolić Aleksandar, Vulić Predrag, Manojlović Dragan. "Application of novel Zn-ferrite modified glassy carbon paste electrode as a sensor for determination of Cd(II) in waste water" in Electroanalysis 26 no. 7, Hoboken, NJ:John Wiley & Sons (2014): 1536-1543. https://doi.org/10.1002/elan.201400095 M22

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  Malathion-induced inhibition of human plasma cholinesterase studied by the fluorescence spectroscopy method cite

  V. M. Pavelkić, K. S. Krinulović, J. Z. Savić, M. A. Ilić (2008)

  The in vitro effect of technical grade malathion was assessed via the kinetic parameters of human plasma butyrylcholinesterase (BChE) using N-methylindoxyl acetate as a substrate for BChE. An inhibitor kinetics study demonstrated the existence of a biphasic inhibition curve, indicating high- and low-affinity binding sites of malathion. The IC50 values as calculated from the experimental inhibition curves were 1.33 × 10–9 and 1.48 × 10–5 M for the high- and low-affinity binding sites, respectively; Hill’s analysis gave 1.29 × ...

  Малатион, инхибиција, хумана плазма холинестераза, метода флуоресцентне спектроскопије

  V. M. Pavelkić, K. S. Krinulović, J. Z. Savić, M. A. Ilić. "Malathion-induced inhibition of human plasma cholinesterase studied by the fluorescence spectroscopy method" in Russian Journal of Physical Chemistry A, Pleiades Publishing Ltd (2008). https://doi.org/10.1134/S0036024408050312 М23

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  The choice of high gradient magnetic separation processes for removal of Fe2O3 carriers from quartz raw material cite

  Sekulić Živko, Bartulović Zoran, Mihajlović Slavica, Ignjatović Miroslav, Savić Ljubinko, Jovanović Vladimir, Nišić Dragana (2017)

  Sekulić Živko, Bartulović Zoran, Mihajlović Slavica, Ignjatović Miroslav, Savić Ljubinko, Jovanović Vladimir, Nišić Dragana. "The choice of high gradient magnetic separation processes for removal of Fe2O3 carriers from quartz raw material" in Gospodarka Surowcami Mineralnymi- Mineral Resources Managnament 33 no. 4, Warsaw, Poland:DE GRUYTER OPEN (2017): 93-106. https://doi.org/https://doi.org/10.1515/gospo- M23

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  Vrednosni aspekt razlaganja proizvodnje u integrisanom privrednom društvu „Kolubare“ i „Tent“ cite

  Maksimović Svetomir, Miljanović Igor, Živojinović Miljanović Ivana (2013)

  Maksimović Svetomir, Miljanović Igor, Živojinović Miljanović Ivana. "Vrednosni aspekt razlaganja proizvodnje u integrisanom privrednom društvu „Kolubare“ i „Tent“" in Zbornik radova XL Simpozijuma o operacionim istraživanjima Symopis, 09-12.09.2013. - no. -, Zlatibor, Srbija:University of Belgrade, Faculty of Organizational Sciences, Belgrade (2013): 762-767. https://doi.org/- M63

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  Faze formiranja grafičke dokumentacije rudnika sa površinskom eksploatacijom cite

  Milutinović Aleksandar, Ganić Aleksandar, Miljanović Igor (2013)

  Milutinović Aleksandar, Ganić Aleksandar, Miljanović Igor. "Faze formiranja grafičke dokumentacije rudnika sa površinskom eksploatacijom" in Zbornik radova XL Simpozijuma o operacionim istraživanjima Symopis, 09-12.09.2013. 1, Zlatibor, Srbija:University of Belgrade, Faculty of Organizational Sciences, Belgrade (2013): 751-756 M63

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  Predlog novog koncepta za algoritamski pristup upravljanju rizicima u površinskoj eksploataciji cite

  Miljanović Igor, Milutinović Aleksandar, Kirin Snežana, Gajić Grozdana (2013)

  Miljanović Igor, Milutinović Aleksandar, Kirin Snežana, Gajić Grozdana. "Predlog novog koncepta za algoritamski pristup upravljanju rizicima u površinskoj eksploataciji" in Zbornik radova XL Simpozijuma o operacionim istraživanjima Symopis, 09-12.09.2013., Zlatibor, Srbija:University of Belgrade, Faculty of Organizational Sciences, Belgrade (2013): 757-761 M63

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  Challenges of Renewable Energy Source Utilisation at Section of Future Highway E-763 Belgrade-Southern Adriatic Across Karst Plateau of Pešter Plateau (Western Serbia) cite

  Milenić Dejan, Stevanović Zoran, Dragišić Veselin, Vranješ Ana, Savić Nevena (2014)

  Milenić Dejan, Stevanović Zoran, Dragišić Veselin, Vranješ Ana, Savić Nevena. "Challenges of Renewable Energy Source Utilisation at Section of Future Highway E-763 Belgrade-Southern Adriatic Across Karst Plateau of Pešter Plateau (Western Serbia)" in Engineering Geology for Society and Territory - Volume 5, Proceedings of the XII IAEG Congress, Torino 2014 5, :Springer International (2014): 581-584. https://doi.org/10.1007/978-3-319-09048-1_113 M33

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  Curcumin nanonization using an alternative small-scale production unit: selection of proper stabilizer applying basic physicochemical consideration and biological activity assessment of nanocrystals cite

  Ines Nikolić, Jelena Antić-Stanković, Dragana Božić, Danijela Ranđelović, Bojan Marković, Dominique Jasmin Lunter, Aleksandar Kremenović, Miroslav Savić, Snežana Savić (2020)

  As the number of poorly soluble drugs is increasing, nanocrystals have become very interesting due to wide range of application possibilities. Curcumin was used as a model active ingredient in this work. Even though it has many proven positive effects, due to its physicochemical issues, its possibilities have not been fully exploited. The goal of this work was to select optimal conditions for a top-down method for curcumin nanosuspension production, and to perform their comprehensive characterization applying complementary methodologies: ...

  nanocrystal, curcumin, top-down method, wetball milling

  Ines Nikolić, Jelena Antić-Stanković, Dragana Božić, Danijela Ranđelović, Bojan Marković, Dominique Jasmin Lunter, Aleksandar Kremenović, Miroslav Savić, Snežana Savić. "Curcumin nanonization using an alternative small-scale production unit: selection of proper stabilizer applying basic physicochemical consideration and biological activity assessment of nanocrystals" in Review on advanced materials science, Walter de Gruyter GmbH (2020). https://doi.org/10.1515/rams-2020-0043 М22

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  Techno-economic assessment of cost-effectiveness of Boron minerals exploitation cite

  Vidanović Nebojša, Tokalić Rade, Ognjanović Sasa, Savić Ljiljana, Savić Ljubinko (2011)

  Vidanović Nebojša, Tokalić Rade, Ognjanović Sasa, Savić Ljiljana, Savić Ljubinko. "Techno-economic assessment of cost-effectiveness of Boron minerals exploitation" in Technics Technologies Education Management / TTEM 6 no. 4, Sarajevo, Bosnia & Herzegovina:DRUNPP, Sarajevo (2011): 1053-1057 M23

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  Kvartarni klastiti iz bušotine kod Aranđelovca (rasadnik Mladost) cite

  Miroslav Radeta (2024)

  U ovom radu analizirani su kvartarni klastiti iz bušotine kod Aranđelovca IB 18-3, sa ciljem boljeg razumevanja njihovih sedimentoloških i litoloških karakteristika. Kvartarni sedimenti su prilično homogenog/uniformisanog sastava i čine ih finozrni klastiti (dominantno alevroliti) sa određenim procentom peskovite i glinovite frakcije. Oni su iskartirani u samoj povlati i debljina im je 27 m. U podini su gornjokredne karbonatne stene (krečnjaci, laporci, rekristalisali/mermerisani karbonati) i miocenski sediment predstavljeni raznovrsnim varijetetima klastično karbonatnih stena. Ispitivani kvartarni sedimenti odlikuju se odsustvom ...

  kvartarni klastiti, alevriti, Aranđelovac, granulometrija, mineraloško petrografski sastav

  Miroslav Radeta. Kvartarni klastiti iz bušotine kod Aranđelovca (rasadnik Mladost), 2024

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  Spektralni sastav seizmičkih talasa pobuđenih različitim dinamičkim izvorima cite

  Aleksandra Savić (1993)

  Spektralni sastav, seizmički talasi, dinamički izvori

  Aleksandra Savić. Spektralni sastav seizmičkih talasa pobuđenih različitim dinamičkim izvorima, Beograd:Rudarsko-geološki fakultet, 1993

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  Uticaj tehničkih parametara na brzinu udarnog bušenja  u različitim stenskim sredinama cite

  Ljubinko Savić (1992)

  Udarno bušenje, brzina, stenske sredine

  Ljubinko Savić. Uticaj tehničkih parametara na brzinu udarnog bušenja  u različitim stenskim sredinama, Beograd:Rudarsko Geološki Fakultet, 1992

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  Uticaj najvažnijih parametara dleta kod udarnog bušenja na brzinu izrade minske bušotine za uslove rudnika Žuta prlina cite

  Ljubinko Savić (1989)

  Udarno bušenje, dleta, minska bušotina, Žuta prlina

  Ljubinko Savić. Uticaj najvažnijih parametara dleta kod udarnog bušenja na brzinu izrade minske bušotine za uslove rudnika Žuta prlina, Beograd:Rudarsko-geološki fakultet, 1989

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  Possibilites of manifold utilisation of Mataruska banja spa thermomineral waters cite

  Savić Nevena, Milenić Dejan, Krunić Olivera (2010)

  Savić Nevena, Milenić Dejan, Krunić Olivera. "Possibilites of manifold utilisation of Mataruska banja spa thermomineral waters" in Spa Congress with international participation 1, Vrnjačka banja:Udruzenje banja Srbije (2010): 182-189 M63

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  Petrology of Plagiogranite from Sjenica, Dinaridic Ophiolite Belt (Southwestern Serbia) cite

  Milovanović Dragan, Srećković Batoćanin Danica, Savić Marija, Popović Danica (2012)

  Milovanović Dragan, Srećković Batoćanin Danica, Savić Marija, Popović Danica. "Petrology of Plagiogranite from Sjenica, Dinaridic Ophiolite Belt (Southwestern Serbia)" in Geologica Carpathica 2 no. 63, Bratislava: (2012): 97-106. https://doi.org/10.2478/v10096-012-0008-4 M23

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  Bacteriological pollution of karst springs in Zlatar, Western Serbia cite

  Milenić Dejan, Milanković Đuro, Savić Nevena, Doroslovac Nenad (2014)

  Milenić Dejan, Milanković Đuro, Savić Nevena, Doroslovac Nenad. "Bacteriological pollution of karst springs in Zlatar, Western Serbia" in Proceedings of the 22nd International Karstological School “Classical Karst” Karst and microorganisms, Postojna, Slovenia, Postojna:Karst Research Institute ZRC SAZU (2014): 54-55 M34

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  Forecast of a possible climate impact on the water balance and regime in the area of Zlatibor Mountain, Serbia, Europe cite

  Milenić Dejan, Savić Nevena (2014)

  Milenić Dejan, Savić Nevena. "Forecast of a possible climate impact on the water balance and regime in the area of Zlatibor Mountain, Serbia, Europe" in Proceedings of the 10th International Hydrogeological Congress, Thessaloniki, Greece (2014): 487-494 M33