Fosfolipaza pankreasa A2 (PLA2) igra važnu ulogu u ćelijskoj homeostazi kao iu procesu karcinogeneze. Efekti metalo-lekova koji se koriste kao hemoterapeutici na aktivnost ovog enzima nisu poznati. U ovom radu, interakcija između PLA2 svinjskog pankreasa i dva odabrana kompleksa prelaznih metala — tetrahloro(bipiridin) platine(IV) ([PtCl4(bipi)]) i dihloro (bipiridin) rutenijum(III)hlorida ([RuCl2(bipi)2) ]Cl)—proučavana je. Laserska desorpcija/jonizacija uz pomoć matriksa, vremenska masa spektrometrija (MALDI-TOF MS) i fluorescentna spektroskopija korišćeni su za analizu aktivnosti enzima u odsustvu i prisustvu metalnih kompleksa i za ...
... E-mail: tina@vinca.rs, marijanapetkovic@vinca.rs,
bojanad@vinca.rs; Fax: +381 11 24 7207; Tel: +381 11 3408692
b Institute for Medical Physics and Biophysics, Medical Faculty,
University of Leipzig, Härtelstraße 16–18, D-04107 Leipzig,
Germany. E-mail: juergen.arnhold@medizin.uni-leipzig.de,
joerg.fl ...
... support of our bilateral
cooperation between the Institute of Nuclear Sciences Vinča in
Belgrade, Serbia and the Institute for Medical Physics and
Biophysics of the University of Leipzig, Germany (Project
number: 50427034). Special thanks also to Lars Thomas for
his help with the fluorescence measurements ...
Tina Kamčeva, Jörg Flemmig, Bojana Damnjanović, Jürgen Arnhold, Aleksandar Mijatović, Marijana Petković. "Inhibitory effect of platinum and ruthenium bipyridyl complexes on porcine pancreatic phospholipase A2" in Metallomics, Oxford University Press (OUP) (2011). https://doi.org/10.1039/c1mt00088h
