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Упит dcterms_subject_txt:Psychiatric drugs

14 items

  • Adsorption and degradation of some psychiatric drugs by sol-gel synthesized titania-based photocatalysts: influence of tungsten and sodium content

    Nina L. Finčur, Maja J. Šćepanović, Mirjana Grujić-Brojčin, Biljana F. Abramović, Jugoslav B. Krstić, Aleksandar Kremenović, Tatjana Srećković, Aleksandar Golubović (2019)
    Mesoporous anatase nanopowders were doped with 0.05−0.5 mol% of W6, in order to obtain more efficient photocatalyst than TiO2 Degussa P25 in the degradation of amitriptyline (AMI) under simulated solar irradiation (SSI). Dominant XRPD peaks were ascribed to anatase phase, with additional peaks which could correspond to brookite, TiO2 bronze and sodium titanate, Na2Ti9O19. The Raman scattering measurements have confirmed anatase as dominant phase, with broad Raman feature at ~270 cm−1 possibly related to Ti–O–Na stretching vibration. All W-doped ...
    Sol-gel synthesis, Doped titania nanopowders, XRPD, Raman spectroscopy, Adsorption and photocatalytic degradation, Psychiatric drugs

  • Human Hemoglobin and Antipsychotics Clozapine, Ziprasidone and Sertindole: Friends or Foes?

    Lena Platanić Arizanović, Nikola Gligorijević, Ilija Cvijetić, Aleksandar Mijatović, Maja Krstić Ristivojević, Simeon Minić, Aleksandra Nikolić Kokić, Čedo Miljević, Milan Nikolić (2023)
    Packed with hemoglobin, an essential protein for oxygen transport, human erythrocytes are a suitable model system for testing the pleiotropic effects of lipophilic drugs. Our study investi gated the interaction between antipsychotic drugs clozapine, ziprasidone, sertindole, and human hemoglobin under simulated physiological conditions. Analysis of protein fluorescence quenching at different temperatures and data obtained from the van’t Hoff diagram and molecular docking indicate that the interactions are static and that the tetrameric human hemoglobin has one binding site for ...
    Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis

  • Inhibitory effect of platinum and ruthenium bipyridyl complexes on porcine pancreatic phospholipase A2

    Tina Kamčeva, Jörg Flemmig, Bojana Damnjanović, Jürgen Arnhold, Aleksandar Mijatović, Marijana Petković (2011)
    Fosfolipaza pankreasa A2 (PLA2) igra važnu ulogu u ćelijskoj homeostazi kao iu procesu karcinogeneze. Efekti metalo-lekova koji se koriste kao hemoterapeutici na aktivnost ovog enzima nisu poznati. U ovom radu, interakcija između PLA2 svinjskog pankreasa i dva odabrana kompleksa prelaznih metala — tetrahloro(bipiridin) platine(IV) ([PtCl4(bipi)]) i dihloro (bipiridin) rutenijum(III)hlorida ([RuCl2(bipi)2) ]Cl)—proučavana je. Laserska desorpcija/jonizacija uz pomoć matriksa, vremenska masa spektrometrija (MALDI-TOF MS) i fluorescentna spektroskopija korišćeni su za analizu aktivnosti enzima u odsustvu i prisustvu metalnih kompleksa i za ...
    Metals and Alloys, Biochemistry, Biomaterials, Biophysics, Chemistry (miscellaneous)
    ... are no data dealing with the interaction of these metallo-drugs with enzymes involved in phospholipid metabolism. Although metal complexes are efficient anti- proliferative agents in solid tumors, there are numerous side effects of these drugs such as nephrotoxicity and tumor cell resistance that must ...
    ... inhibitory effect of metallo- drugs on the secretory PLA2 might slow down the process of protrusion of tumor cells by decreasing the concentration of mediators of cellular signaling, such as metabolites of arachidonic acid and lysophospholipids. Additional effects of metallo- drugs on the death of tumor ...
    ... all might contribute to a lower efficiency of the anti-tumor therapy with metallo-drugs. Finally, results presented in this work emphasize the neces- sity to better clarify the effect of individual metallo-drugs on various types of secretory PLA2 enzymes, because they possess different amino acids ...

  • NMR kinetic studies of the interactions between [Ru(terpy)(bipy)(H2O)]2+ and some sulfur-donor ligands

    Aleksandar Mijatović, Biljana Šmit, Ana Rilak, Biljana Petrović, Dragan Čanović, Živadin D. Bugarčić (2012)
    Reakcije supstitucije monofunkcionalnog [Ru(terpi)(bipi)(H2O)]2+ kompleksa, gde je terpi = 2,2′:6′,2″-terpiridin i bipi = 2,2′-bipiridin, sa biološki relevantnim sumporo donorskim ligandima, kao što su tiourea, l-metionin, l-cistein i glutation, proučavane su u vodenim rastvorima tehnikom 1H i 13C NMR spektroskopije. Sve reakcije su proučavajne na pH 7,4, u prisustvu fosfatnog pufera, da bi se oponašalo fiziološko okruženje tokom procesa supstitucije. Reakcije se izvode na 295 K pod uslovima reakcija drugog reda. Uočeni rezultati pokazuju da brzina supstitucije snažno zavisi ...
    Materials Chemistry,Inorganic Chemistry,Physical and Theoretical Chemistry

  • Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes

    Milica Međedović, Aleksandar Mijatović, Rada Baošić, Dejan Lazić, Žiko Milanović, Zoran Marković, Jelena Milovanović, Dragana Arsenijević, Bojana Stojanović, Miloš Arsenijević, Marija Milovanović, Biljana Petrović, Ana Rilak Simović (2023)
    In order to discover new anticancer drugs, novel ruthenium(III) complexes [Ru(L)Cl(H2O)], where L is tetradentate Schiff base bis(acetylacetone)ethylendiimine (acacen, 1), bis(benzoylacetone)ethylendiimine (bzacen, 2), (acetylacetone)(benzoylaceton)ethylendiimine (acacbzacen, 3), bis(acetylacetone)propylendiimine (acacpn, 4), bis(benzoylacetone)propylendiimine (bzacpn, 5) or (acetylacetone)(benzoylaceton)propylendiimine (acacbzacpn, 6), were synthesized. The complexes 1 – 6 were characterized by elemental analysis, molar conductometry, and by various spectroscopic techniques, such as UV–Vis, IR, EPR, and ESI-MS. Based on in vitro DNA/BSA experiments, complexes 2 (bzacen) and 5 (bzacpn) with two aromatic rings showed ...
    Inorganic Chemistry, Biochemistry

  • Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach

    Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)
    Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...
    pyrazoloquinolinones, nanocrystals, wet media milling, fasted/fed bioavailability
    ... of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs. Int. J. Pharm. 1995, 125, 91–97. [CrossRef] 32. Mou, D.; Chen, H.; Wan, J.; Xu, H.; Yang, X. Potent dried drug nanosuspensions for oral bioavailability enhancement of poorly soluble drugs with pH-dependent ...
    ... Pharm. Sin. B 2015, 5, 442–453. [CrossRef] 7. Dening, T.J.; Rao, S.; Thomas, N.; Prestidge, C.A. Oral nanomedicine approaches for the treatment of psychiatric illnesses. J. Control Release 2016, 223, 137–156. [CrossRef] [PubMed] 8. Peltonen, L.; Hirvonen, J. Pharmaceutical nanocrystals by nanomilling: ...
    ... media milling; fasted/fed bioavailability 1. Introduction The emerging trends in the combinatorial chemistry and design of psychopharmaco- logical drugs led to the development of drug candidates with increased lipophilicity and high molecular weight. It is estimated that 90% of new chemical entities ...

  • Curcumin nanonization using an alternative small-scale production unit: selection of proper stabilizer applying basic physicochemical consideration and biological activity assessment of nanocrystals

    Ines Nikolić, Jelena Antić-Stanković, Dragana Božić, Danijela Ranđelović, Bojan Marković, Dominique Jasmin Lunter, Aleksandar Kremenović, Miroslav Savić, Snežana Savić (2020)
    As the number of poorly soluble drugs is increasing, nanocrystals have become very interesting due to wide range of application possibilities. Curcumin was used as a model active ingredient in this work. Even though it has many proven positive effects, due to its physicochemical issues, its possibilities have not been fully exploited. The goal of this work was to select optimal conditions for a top-down method for curcumin nanosuspension production, and to perform their comprehensive characterization applying complementary methodologies: ...
    nanocrystal, curcumin, top-down method, wetball milling

  • Supstitucione reakcije Pd(II) kompleksa sa biološki važnim biomolekulima

    Aleksandar M. Mijatović, Jovana Bogojeski (2017)
    Kompleksi Pd(II), supstitucione reakcije

  • Equilibrium and kinetic studies of the reactions between [Ru(terpy)(bipy)Cl]Cl complex and biologically important N-donor ligands

    Aleksandar Mijatović, Biljana Petrović, Ratomir Jelić, Živadin Bugarčić (2011)
    Studije u oblasti antikancerogenih karakteristika jedinjenja rutenijuma(III/II) izazivaju veliku pažnju već nekoliko godina otkako su neka od njih kao što su KP1019 (indazolijum-tetrahloridobis(H-indazol)rutenat(III)) i NAMI-A (imidazolijum) -trans-tetrahlorido(dimetilsulfoksid)indazolerutenat(III)) dostigao nivo kliničkog ispitivanja. Kompleksi rutenijuma u ​​reakciji sa molekulom DNK formiraju prvenstveno gvanin- i adenin-adukt, kao komplekse platine. Takođe, nekoliko studija ukazuje na veoma jake interakcije sa proteinima. Međutim, kompleksi Ru(III/II) pokazuju generalno manje toksične efekte od lekova platine(II).1 Proučavali smo kinetiku reakcija supstitucije kompleksa [Ru(terpi)(bipi)Cl]Cl sa biološki važnim ligandima: dimetilsulfoksidom, gvanozin-5’-monofosfatom, ...

  • Kinetics, mechanism, and equilibrium studies of the reactions between a ruthenium(II) complex and some nitrogen- and sulfur-donor nucleophiles

    Aleksandar M. Mijatović, Ratomir M. Jelić, Jovana Bogojeski, Živadin D. Bugarčić, Biljana Petrović (2013)
    Kinetika i mehanizam reakcija supstitucije između [Ru(trpi)(bpi)Cl]+ sa nukleofilima gvanozin-5′-monofosfatom, L-histidinom, tioureom i dimetilsulfoksidom proučavani su spektrofotometrijski u 0,1 M NaClO4 na 310 K. Red reaktivnosti za odabrane ligande je: tiourea > gvanozin-5′-monofosfat > L-histidin > DMSO. Ovaj red je povezan sa elektronskim, strukturnim i hemijskim karakteristikama kompleksa i nukleofila. Reakcija supstitucije sa tioureom je proučavana na tri različite temperature (288, 298 i 310 K). Negativna entropija aktivacije DS = potvrđuje asocijativni način aktivacije. Formiranje kompleksa [Ru(trpi)(bpi)H2O]2+ sa ligandima ...
    Kinetika, Ravnoteža, Ru(II), L-Histidin, Guanozin-5' -monofosfat, Dimetilsulfoksid, Tiourea
    ... limited range of activity of cisplatin and its analogs and their several side effects have stimulated the search for other metal-based anticancer drugs with metal ions differ- ent from platinum [4, 5]. Ruthenium complexes are today the most promising compounds for the investigation of antitumor activity ...
    ... NAMI-A, which is relatively non-toxic but has antimet- astatic activity [21–25]. It is generally accepted that the antitumor activity of platinum drugs can be ascribed to interactions between complex and DNA molecules [1–5]. However, the mech- anism of action of ruthenium compounds has not yet been ...
    ... J, Novakova O, Vrana O, Brabec V (1995) Inorg Chim Acta 231:57 14. Vilaplana R, Romero M, Quiros M, Salas J, Gonzalez-Vilches F (1995) Met-Based Drugs 2:211 15. Chatterjee D, Mitra A, De GS (2006) Platinum Met Rev 50:2 16. Alessio E, Mestroni G, Nardin G, Attia WM, Calligaris M, Sava G, Zorzet S ...

  • Mineral Resources of Serbia: Environmental, Societal and Economic Challenges

    Vladimir Simić, Rade Jelenković, Dragana Životić (2019)
    ... the global adult population) used drugs at least once in 2015. The amounts of illicit drugs consumed worldwide are comparable with those of therapeutic drugs (Zuccato and Castiglioni 2009). A detailed statistics on the production and consumption of illicit drugs worldwide is presented and discussed ...
    ... the presence of 14 drugs, and traces of trimethoprim, carbamazepine, 4-FAA, 4-AAA and lorazepam were detected. Based on the results of this study it was concluded that generally there were no leaching of drugs from surface to groundwater. The residues of 81 pharmaceutical drugs in waste, surface ...
    ... (PFOS) up to 5.7 ng g'! dry weight (dw) and total perfluorinated compounds (PFCs) up to 6.3 ng g!! dry weight were detected. Drugs of Abuse Drugs of abuse or IIlicit drugs are the latest group of emerging pollutants identified in the environment (Calvo-Flores et al. 2018). They were detected in ...

  • The interaction of organoselenium trans-palladium(II) complexes toward small-biomolecules and CT-DNA

    Vera M. Divac, Aleksandar Mijatović, Marina D. Kostić, Jovana Bogojeski (2017)
    Serija organoselenijum trans-paladijum(II) kompleksa 1 (bis(2-(fenilselanilmetil)oksolan)dihloropaladijum(II)), 2 (bis(2-(fenilselanilmetil)oksan)dihloropaladijum(II)) i 3 (bis(2) ,2-dimetil-3-(fenilselanil)oksan)dihloropaladijum(II)) su korišćeni za ispitivanje reaktivnosti ovog specifičnog tipa kompleksa prema različitim bio-molekulima. Ovaj sistem je od posebnog interesa jer se jako malo zna o supstitucionim reakcijam organoselenijum paladijum(II) kompleksa sa trans konfiguracijom. Zamena koordinovanog hlorida sa serijom malih bio-molekula (l-Met, l-His, l-Cis, GSH i 5′-GMP) proučavana je pod uslovima pseudo-prvog reda kao funkcija koncentracije nukleofila i temperature korišćenjem tehnika zaustavljenog toka. Rezultati za proučavane komplekse ukazuju da ...
    Pd(II), Selen, Substitucija, Kinetika, Mehanizam

  • Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases

    Nikola Stevanović, Aleksandar Mijatović, Aleksandar Lolić, Mario Zlatović, Rada Baošić (2021)
    Ispitivani su uticaji primene mono- i dvokomponentnih organskih modifikatora na određivanje lipofilnosti 12 tetradentatnih Šifovih baza metodom reverzno-fazne tankoslojne hromatografije. Osnovni cilj je da se proceni tip interakcije između posmatranih jedinjenja i komponenti primenjenih hromatografskih sistema i uspostavi neki obrazac ponašanja kako bi se lakše izabrala kombinacija organskih modifikatora koji će simulirati interakciju u biološkim sistemima na osnovu činjenica da iste osnovne intermolekularne interakcije su odgovorne za ponašanje supstanci i u biološkom i u hromatografskom sistemu. Primenjeni organski modifikator ...
    Šifove baze, Lipofilnost, RP-TLC, Organski modifikatori

  • Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study

    Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)
    Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...
    Pharmaceutical Science
    ... https://doi.org/10.1016/50008-6215(01)00182-3. Al-Kassas, R., Bansal, M., Shaw, J., 2017. Nanosizing techniques for improving bioavailability of drugs. J Control Release 260, 202–212. https://doi.org/10.1016/. jeonrel.2017.06.003. Anko, M., Bjelošević, M., Planinšek, O., Trstenjak, U., Logar, M ...