Претрага
177 items
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Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach
Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...... top-down techniques, wet media milling is considered optimal early in pharmaceutical development. One of the most important process parameters that affect the kinetics of particle size decrease is milling duration [16]. According to particle size measurements right after preparation, milling time had a significant ...
... particle size and three months’ stability were prepared by the modified wet media milling technique. Content of DK-I-60-3 in developed dispersions close to theoretical values indicated no significant adsorption of DK-I-60-3 to milling beads, while XRPD proved no impurities from the material of the used ...
... bioavailability of DK-I-60-3. Nanocrystal dispersions stabilized by sodium lauryl sulfate and polyvinylpyrrolidone were prepared by modified wet media milling technique, with the selection of appropriate process and formulation parameters. The nanoparticles characterization included particle size and ...Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188
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Curcumin nanonization using an alternative small-scale production unit: selection of proper stabilizer applying basic physicochemical consideration and biological activity assessment of nanocrystals
Ines Nikolić, Jelena Antić-Stanković, Dragana Božić, Danijela Ranđelović, Bojan Marković, Dominique Jasmin Lunter, Aleksandar Kremenović, Miroslav Savić, Snežana Savić (2020)As the number of poorly soluble drugs is increasing, nanocrystals have become very interesting due to wide range of application possibilities. Curcumin was used as a model active ingredient in this work. Even though it has many proven positive effects, due to its physicochemical issues, its possibilities have not been fully exploited. The goal of this work was to select optimal conditions for a top-down method for curcumin nanosuspension production, and to perform their comprehensive characterization applying complementary methodologies: ...Ines Nikolić, Jelena Antić-Stanković, Dragana Božić, Danijela Ranđelović, Bojan Marković, Dominique Jasmin Lunter, Aleksandar Kremenović, Miroslav Savić, Snežana Savić. "Curcumin nanonization using an alternative small-scale production unit: selection of proper stabilizer applying basic physicochemical consideration and biological activity assessment of nanocrystals" in Review on advanced materials science, Walter de Gruyter GmbH (2020). https://doi.org/10.1515/rams-2020-0043
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Microstructural and magnetic properties of electrospun hematite/cuprospinel composites
Phase composition, microstructural and magnetic properties of electrospun hematite/cuprospinel composites were investigated. Samples were synthesized starting with 0 to 10 mol% of copper relative to iron. The round shape of reference electrospun fbres was preserved upon their heating up to 600 °C in air, whereas at 700 °C hollow substructure was additionally formed. In these reference samples the presence of hematite phase was detected by XRPD. A small amount (traces) of Fe3O4 /γ-Fe2O3 was also found, due to the ...Electrical and Electronic Engineering, Condensed Matter Physics, Atomic and Molecular Physics and Optics, Electronic, Optical and Magnetic MaterialsMira Ristić, Aleksandar Kremenović, Michael Reissner, Željka Petrović, Svetozar Musić. "Microstructural and magnetic properties of electrospun hematite/cuprospinel composites" in Journal of Materials Science: Materials in Electronics, Springer Science and Business Media LLC (2020). https://doi.org/10.1007/s10854-020-03526-0
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Microstructure refinement and physical properties of Ag-SnO2 based contact materials prepared by high-energy ball milling
Ćosović Vladan, Pavlović Mila, Ćosović Aleksandar, Vulić Predrag, Premović Milena, Živković Dragana, Talijan Nadežda (2013)Ćosović Vladan, Pavlović Mila, Ćosović Aleksandar, Vulić Predrag, Premović Milena, Živković Dragana, Talijan Nadežda. "Microstructure refinement and physical properties of Ag-SnO2 based contact materials prepared by high-energy ball milling" in Science of Sintering 45, Belgrade:Yugoslav Committee for ETAN (2013): 173-180. https://doi.org/10.2298/SOS1302173C
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Characterization of bituminite in Kimmeridge Clay by confocal laser scanning and atomic force microscopy
Paul C. Hackley, Jolanta Kus, João Graciano Mendonça Filho, Andrew D. Czaja, Angeles G. Borrego, Dragana Životić, Brett J. Valentine, Javin J. Hatcheries (2022)This work investigates bituminite (amorphous sedimentary organic matter) in Upper Jurassic Kimmeridge Clay source rock via confocal laser scanning microscopy (CLSM) and atomic force microscopy (AFM). These petrographic tools were used to provide better understanding of the nature of bituminite, which has been historically difficult to identify and differentiate from similar organic matter types in source rocks. As part of an International Committee for Coal and Organic Petrology (ICCP) working group, an immature (0.42% vitrinite reflectance), organic-rich (44.1 wt% ...Битуминит, Kонфокална ласерска скенирајућа микроскопија, Mикроскопија атомских сила, Органска петрологија, Термичка зрелостPaul C. Hackley, Jolanta Kus, João Graciano Mendonça Filho, Andrew D. Czaja, Angeles G. Borrego, Dragana Životić, Brett J. Valentine, Javin J. Hatcheries. "Characterization of bituminite in Kimmeridge Clay by confocal laser scanning and atomic force microscopy" in International Journal of Coal Geology, Elsevier BV (2022). https://doi.org/10.1016/j.coal.2022.103927
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Synthesis and characterization of high-pressure and high-temperature sphene (CaTiSiO5)
Jelena Pantić, Vladimir Urbanovich, Vesna Poharc-Logar, Bojan Jokić, Marija Stojmenović, Aleksandar Kremenović, Branko Matović (2014)Sphene (CaTiSiO5), a calcium titanosilicate ceramic has been prepared from a powder mixture of CaCO3, TiO2 and SiO2 using vibro-milling for homogenization and activation of precursors. During the highpressure and high-temperature synthesis (HPS) process at 4 GPa and 1,200 °C, sphene undergoes into phase transition, from room-temperature phase P21/a to high-temperature phase A2/a. Evidence of that structural phase transition is given in this paper using infrared, Raman spectroscopy and X-ray powder diffraction. Rietveld refinement was employed to get the ...Jelena Pantić, Vladimir Urbanovich, Vesna Poharc-Logar, Bojan Jokić, Marija Stojmenović, Aleksandar Kremenović, Branko Matović. "Synthesis and characterization of high-pressure and high-temperature sphene (CaTiSiO5)" in Physics and Chemistry of Minerals, Springer Science and Business Media LLC (2014). https://doi.org/10.1007/s00269-014-0693-x
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Mechanosynthesis and structural characterization of nanocrystalline Ce1–Y O2– (x=0.1–0.35) solid solutions
Martin Fabián, Bratislav Antić, Vladimír Girman, Milica Vučinić-Vasić, Aleksandar Kremenović, Shigeru Suzuki, Horst Hahn, Vladimír Šepelák (2015)A series of nanostructuredfluorite-type Ce1–xYxO2–δ (0rxr0.35) solid solutions, prepared via highenergy milling of the CeO2/Y2O3mixtures, are investigated by XRD, HR-TEM, EDS and Raman spectroscopy. For thefirst time, complementary information on both the long-range and short-range structural features of mechanosynthesized Ce1–xYxO2–δ, obtained by Rietveld analysis of XRD data and Raman spectroscopy, is provided. The lattice parameters of the as-prepared solid solutions decrease with increasing yttrium content. Rietveld refinements of the XRD data reveal increase in microstrains in the host ceria ...Martin Fabián, Bratislav Antić, Vladimír Girman, Milica Vučinić-Vasić, Aleksandar Kremenović, Shigeru Suzuki, Horst Hahn, Vladimír Šepelák. "Mechanosynthesis and structural characterization of nanocrystalline Ce1–Y O2– (x=0.1–0.35) solid solutions" in Journal of Solid State Chemistry, Elsevier BV (2015). https://doi.org/10.1016/j.jssc.2015.06.027
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Microemulsion with aromatic oil as cleaner media for electropolymerisation
Abstract Microemulsion polymerization is widely used as a cleaner alternative way to prepare intrinsically conductive polymers. We studied isothermal phase diagrams for microemulsions of the electropolymerizable heterocyclic aromatic oil 3,4-ethylenedioxythiophene (EDOT), aqueous LiClO4 solution and alkyl polyethoxylate. Our specific goal was to assess the effect of LiClO4 salt on the phase behaviour. The phase behaviour was characterized by stepwise titration and microscopic analyses. Here we found that the increase of the concentration of LiClO4 salt shifts the microemulsion region ...M. Ilić, F.-H. Haegel, S. Zlatanovic, N. Potkonjak, B. Simonovic. "Microemulsion with aromatic oil as cleaner media for electropolymerisation" in Environmental Chemistry Letters, Springer Science and Business Media LLC (2005). https://doi.org/10.1007/s10311-005-0101-3
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Application of VIКOR method in the selection of an optimal splution of excavation “Borska Reka” ore deposit
Sanja Bajić, Dragoljub Bajić, Branko Glušćević, Radmila Gaćina. "Application of VIКOR method in the selection of an optimal splution of excavation “Borska Reka” ore deposit" in 9th International Conference Mining and Environmental protection MEP, 24 – 27 May 2023, Sokobanja, Serbia , Belgrade : University of Belgrade-Faculty of mining and geology (2023)
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A Twitter Corpus and Lexicon for Abusive Speech Detection in Serbian
Uvredljivi govor na društvenim medijima, uključujući psovke, pogrdni govor i govor mržnje, dostigao je nivo pandemije. Sistem koji bi bio u stanju da detektuje takve tekstove mogao bi da pomogne da internet i društveni mediji postanu bolji virtuelni prostor sa više poštovanja. Istraživanja i komercijalna primena u ovoj oblasti do sada su bili fokusirani uglavnom na engleski jezik. Ovaj rad predstavlja rad na izgradnji AbCoSER-a, prvog korpusa uvredljivog govora na srpskom jeziku. Korpus se sastoji od 6.436 ručno označenih ...... Web and Social Media, volume 11/1, 2017. 14 Mai ElSherief, Vivek Kulkarni, Dana Nguyen, William Yang Wang, and Elizabeth Belding. Hate lingo: A target-based linguistic analysis of hate speech in social media. In Proceedings of the International AAAI Conference on Web and Social Media, volume 12/1, 2018 ...
... Belgrade, Serbia Abstract Abusive speech in social media, including profanities, derogatory and hate speech, has reached the level of a pandemic. A system that would be able to detect such texts could help in making the Internet and social media a better and more respectful virtual space. Research ...
... SemEval-2020 Task 12: Retraining mBERT on Social Media and Fine-tuned Offensive Language Models. In Proceedings of the 14th International Workshop on Semantic Evaluation(SemEvaleval), 2020. 11 Çağrı Çöltekin. A corpus of Turkish offensive language on social media. In Proceedings of the 12th Language Resources ...Danka Jokić, Ranka Stanković, Cvetana Krstev, Branislava Šandrih. "A Twitter Corpus and Lexicon for Abusive Speech Detection in Serbian" in 3rd Conference on Language, Data and Knowledge (LDK 2021), MDPI AG (2021). https://doi.org/10.4230/OASIcs.LDK.2021.13
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On the Dirichlet divisor problem in short intervals
Ivić Aleksandar, Zhai Wenguang (2014)Ivić Aleksandar, Zhai Wenguang. "On the Dirichlet divisor problem in short intervals" in The Ramanujan Journal no. 33, New York, USA:Springer Science+Business Media (2014): 447-465. https://doi.org/10.1007/s11139-013-9470-6
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An efficient class of optimal sixteenth-order root-finding methods and their basins of attraction
Dejan Ćebić, Nebojša M. Ralević (2022)Dejan Ćebić, Nebojša M. Ralević. "An efficient class of optimal sixteenth-order root-finding methods and their basins of attraction" in Journal of Mathematical Chemistry, Springer Science and Business Media LLC (2022). https://doi.org/10.1007/s10910-022-01371-6
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Intrinsic groundwater vulnerability assessment by multiparameter methods, a case study of Suva Planina Mountain (SE Serbia)
Branislav Petrović (2020)Branislav Petrović. "Intrinsic groundwater vulnerability assessment by multiparameter methods, a case study of Suva Planina Mountain (SE Serbia)" in Environmental Earth Sciences, Springer Science and Business Media LLC (2020). https://doi.org/10.1007/s12665-020-8825-8
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A hydraulic–hydrochemical approach to impact assessment of a grout curtain on karst aquifer behavior
Igor Jemcov, Marina Ćuk Đurović (2020)Igor Jemcov, Marina Ćuk Đurović. "A hydraulic–hydrochemical approach to impact assessment of a grout curtain on karst aquifer behavior" in Hydrogeology Journal, Springer Science and Business Media LLC (2020). https://doi.org/10.1007/s10040-020-02245-4
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Rare earth elements in mineral waters in Serbia
Earth-Surface Processes, Geology, Pollution, Soil Science, Water Science and Technology, Environmental Chemistry, Global and Planetary ChangeMaja Todorović, Marina Ćuk Đurović, Jana Štrbački, Petar Papić. "Rare earth elements in mineral waters in Serbia" in Environmental Earth Sciences, Springer Science and Business Media LLC (2020). https://doi.org/10.1007/s12665-020-09029-9
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Tl(I) sequestration by pharmacosiderite supergroup arsenates: synthesis, crystal structures and relationships in Tl(I)–M(III)–As(V)–H2O (M = Al, Fe) system
Tamara Đorđević, Tarik Karasalihović, Michael Stöger-Pollach, Ljiljana Karanović. "Tl(I) sequestration by pharmacosiderite supergroup arsenates: synthesis, crystal structures and relationships in Tl(I)–M(III)–As(V)–H2O (M = Al, Fe) system" in Mineralogy and Petrology, Springer Science and Business Media LLC (2023). https://doi.org/10.1007/s00710-023-00823-4
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Predictive modeling for U and Th concentrations in mineral and thermal waters, Serbia
Earth-Surface Processes, Geology, Pollution, Soil Science, Water Science and Technology, Environmental Chemistry, Global and Planetary ChangeMarina Ćuk Đurović, Igor Jemcov, Maja Todorović, Ana Mladenović, Petar Papić, Jana Štrbački. "Predictive modeling for U and Th concentrations in mineral and thermal waters, Serbia" in Environmental Earth Sciences, Springer Science and Business Media LLC (2020). https://doi.org/10.1007/s12665-020-09204-y
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Origin, diversity and geothermal potentiality of thermal and mineral waters in Vrnjačka Banja, Serbia
Earth-Surface Processes, Geology, Pollution, Soil Science ,Water Science and Technology, Environmental Chemistry, Global and Planetary ChangeJana Štrbački, Vladimir Živanović, Marina Ćuk Đurović, Nebojša Atanacković, Veselin Dragišić. "Origin, diversity and geothermal potentiality of thermal and mineral waters in Vrnjačka Banja, Serbia" in Environmental Earth Sciences, Springer Science and Business Media LLC (2020). https://doi.org/10.1007/s12665-020-09050-y
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A new analytical method for determination of discharge duration in tunnels subjected to groundwater inrush
Mohsen Golian, Ebrahim Sharifi Teshnizi, Mario Parise, Josip Terzić, Sasa Milanović, Vesna Ristić Vakanjac, Masoud Mahdad, Mehdi Abbasi, Hossein Taghikhani, Habib Saadat (2021)Mohsen Golian, Ebrahim Sharifi Teshnizi, Mario Parise, Josip Terzić, Sasa Milanović, Vesna Ristić Vakanjac, Masoud Mahdad, Mehdi Abbasi, Hossein Taghikhani, Habib Saadat. "A new analytical method for determination of discharge duration in tunnels subjected to groundwater inrush" in Bulletin of Engineering Geology and the Environment, Springer Science and Business Media LLC (2021). https://doi.org/10.1007/s10064-021-02140-6
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Genesis and metallogenetic setting of the polymetallic barite-sulphide deposit, Bobija, Western Serbia
Marcel Maurer, Dejan Prelević, Regina Mertz-Kraus, Aleksandar Pačevski, Bojan Kostić, Jovana Malbašić (2019)Trejs elementi u sfaleritu, izotopi sumpora, datiranje cirkonom, SEDEX, SHMS, dominantno klastični Pb-Zn, sulfidi, ležištaMarcel Maurer, Dejan Prelević, Regina Mertz-Kraus, Aleksandar Pačevski, Bojan Kostić, Jovana Malbašić. "Genesis and metallogenetic setting of the polymetallic barite-sulphide deposit, Bobija, Western Serbia" in International Journal of Earth Sciences, Springer Science and Business Media LLC (2019). https://doi.org/10.1007/s00531-019-01732-8